P36844 (SPIKE_ADE04) Reviewed, UniProtKB/Swiss-Prot
Last modified May 1, 2013. Version 53. History...
Names and origin
|Protein names||Recommended name:|
|Organism||Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)|
|Taxonomic identifier||28280 [NCBI]|
|Taxonomic lineage||Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus E|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||426 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface By similarity.
Homotrimer. Interacts with host receptor CXCAR. Interacts (via N-terminal tail region) with pentons By similarity.
Expressed in the late phase of the viral replicative cycle.
The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion By similarity.
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.
Belongs to the adenoviridae fiber family.
|Biological process||Host-virus interaction|
Viral attachment to host cell
Virus entry into host cell
|Cellular component||Host nucleus|
|Developmental stage||Late protein|
|Molecular function||Capsid protein|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: InterPropathogenesis
Inferred from electronic annotation. Source: InterProviral attachment to host cell
Inferred from electronic annotation. Source: UniProtKB-KWviral entry into host cell
Inferred from electronic annotation. Source: UniProtKB-KWviral infectious cycle
Inferred from electronic annotation. Source: InterPro
|Cellular_component||host cell nucleus|
Inferred from electronic annotation. Source: UniProtKB-SubCellviral capsid
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 426||426||Fiber protein||PRO_0000221788|
|X76547 Genomic DNA. Translation: CAA54049.1.|
3D structure databases
|SMR||P36844. Positions 236-426. |
Protocols and materials databases
Family and domain databases
|Gene3D||184.108.40.206. 3 hits. |
220.127.116.11. 1 hit.
|InterPro||IPR000931. Adeno_fibre. |
|Pfam||PF00541. Adeno_knob. 1 hit. |
PF00608. Adeno_shaft. 2 hits.
|PRINTS||PR00307. ADENOVSFIBRE. |
|SUPFAM||SSF49835. Viral_att. 1 hit. |
SSF51225. Viral_att_shaft. 1 hit.
|Accession||Primary (citable) accession number: P36844|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families