Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dipeptide and tripeptide permease B

Gene

dtpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.1 Publication

Enzyme regulationi

Inhibited by CCCP but unaffected by sodium depletion.1 Publication

GO - Molecular functioni

  • antibiotic transporter activity Source: EcoCyc
  • dipeptide transmembrane transporter activity Source: EcoCyc
  • hydrogen ion transmembrane transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: EcoCyc
  • tripeptide transporter activity Source: EcoCyc

GO - Biological processi

  • antibiotic transport Source: EcoCyc
  • dipeptide transmembrane transport Source: EcoCyc
  • hydrogen ion transmembrane transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
  • tripeptide transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHIP-MONOMER.
ECOL316407:JW3463-MONOMER.
MetaCyc:YHIP-MONOMER.

Protein family/group databases

TCDBi2.A.17.1.3. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide and tripeptide permease B
Gene namesi
Name:dtpB
Synonyms:yhiP
Ordered Locus Names:b3496, JW3463
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12232. dtpB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 52PeriplasmicSequence analysis4
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 82CytoplasmicSequence analysis9
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 106PeriplasmicSequence analysis3
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 172PeriplasmicSequence analysis5
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 210CytoplasmicSequence analysisAdd BLAST17
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 233PeriplasmicSequence analysis2
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 267CytoplasmicSequence analysisAdd BLAST13
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 311PeriplasmicSequence analysisAdd BLAST23
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 350CytoplasmicSequence analysisAdd BLAST18
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 380PeriplasmicSequence analysis9
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 411CytoplasmicSequence analysis10
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 456PeriplasmicSequence analysisAdd BLAST24
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 489CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643291 – 489Dipeptide and tripeptide permease BAdd BLAST489

Proteomic databases

PaxDbiP36837.
PRIDEiP36837.

Interactioni

Protein-protein interaction databases

BioGridi4261541. 184 interactors.
DIPiDIP-12369N.
IntActiP36837. 1 interactor.
MINTiMINT-1286392.
STRINGi511145.b3496.

Structurei

3D structure databases

ProteinModelPortaliP36837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP36837.
KOiK03305.
OMAiFYVLYAQ.
PhylomeDBiP36837.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01879. PTR2_DtpB_subfam. 1 hit.
InterProiIPR023778. AA/pep_transptr_DtpB.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTTPMGML QQPRPFFMIF FVELWERFGY YGVQGVLAVF FVKQLGFSQE
60 70 80 90 100
QAFVTFGAFA ALVYGLISIG GYVGDHLLGT KRTIVLGALV LAIGYFMTGM
110 120 130 140 150
SLLKPDLIFI ALGTIAVGNG LFKANPASLL SKCYPPKDPR LDGAFTLFYM
160 170 180 190 200
SINIGSLIAL SLAPVIADRF GYSVTYNLCG AGLIIALLVY IACRGMVKDI
210 220 230 240 250
GSEPDFRPMS FSKLLYVLLG SVVMIFVCAW LMHNVEVANL VLIVLSIVVT
260 270 280 290 300
IIFFRQAFKL DKTGRNKMFV AFVLMLEAVV FYILYAQMPT SLNFFAINNV
310 320 330 340 350
HHEILGFSIN PVSFQALNPF WVVLASPILA GIYTHLGNKG KDLSMPMKFT
360 370 380 390 400
LGMFMCSLGF LTAAAAGMWF ADAQGLTSPW FIVLVYLFQS LGELFISALG
410 420 430 440 450
LAMIAALVPQ HLMGFILGMW FLTQAAAFLL GGYVATFTAV PDNITDPLET
460 470 480
LPVYTNVFGK IGLVTLGVAV VMLLMVPWLK RMIATPESH
Length:489
Mass (Da):53,575
Last modified:November 1, 1997 - v2
Checksum:i80AB5CE4E3880448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18472.1.
U00096 Genomic DNA. Translation: AAC76521.1.
AP009048 Genomic DNA. Translation: BAE77798.1.
PIRiC65147.
RefSeqiNP_417953.1. NC_000913.3.
WP_001098652.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76521; AAC76521; b3496.
BAE77798; BAE77798; BAE77798.
GeneIDi948006.
KEGGiecj:JW3463.
eco:b3496.
PATRICi32122442. VBIEscCol129921_3598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18472.1.
U00096 Genomic DNA. Translation: AAC76521.1.
AP009048 Genomic DNA. Translation: BAE77798.1.
PIRiC65147.
RefSeqiNP_417953.1. NC_000913.3.
WP_001098652.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261541. 184 interactors.
DIPiDIP-12369N.
IntActiP36837. 1 interactor.
MINTiMINT-1286392.
STRINGi511145.b3496.

Protein family/group databases

TCDBi2.A.17.1.3. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

PaxDbiP36837.
PRIDEiP36837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76521; AAC76521; b3496.
BAE77798; BAE77798; BAE77798.
GeneIDi948006.
KEGGiecj:JW3463.
eco:b3496.
PATRICi32122442. VBIEscCol129921_3598.

Organism-specific databases

EchoBASEiEB2144.
EcoGeneiEG12232. dtpB.

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP36837.
KOiK03305.
OMAiFYVLYAQ.
PhylomeDBiP36837.

Enzyme and pathway databases

BioCyciEcoCyc:YHIP-MONOMER.
ECOL316407:JW3463-MONOMER.
MetaCyc:YHIP-MONOMER.

Miscellaneous databases

PROiP36837.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01879. PTR2_DtpB_subfam. 1 hit.
InterProiIPR023778. AA/pep_transptr_DtpB.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTPB_ECOLI
AccessioniPrimary (citable) accession number: P36837
Secondary accession number(s): P76706, Q2M7F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Although DtpB appears to represent a system of lower affinity, there is an obvious redundancy in substrate specificity as compared with DtpA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.