P36835 (IL2_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-2
Short name=IL-2

Alternative name(s):
T-cell growth factor
Short name=TCGF

Gene names

Name:

IL2

Organism

Capra hircus (Goat)

Taxonomic identifier

9925 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-2 family.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 155	135	Interleukin-2		PRO_0000015477
Amino acid modifications
	Glycosylation	23	1	O-linked (GalNAc...) By similarity
	Disulfide bond	79 ↔ 127		By similarity
Experimental info
	Sequence conflict	3 – 5	3	RMQ → QIP in AAB38527. Ref.2
	Sequence conflict	22	1	P → T in AAB38527. Ref.2
	Sequence conflict	30	1	T → P in AAB38527. Ref.2
	Sequence conflict	51	1	L → P in AAB38527. Ref.2
	Sequence conflict	71	1	D → A in AAB38527. Ref.2
	Sequence conflict	89	1	D → E in AAB38527. Ref.2
	Sequence conflict	99	1	R → L in AAB38527. Ref.2
	Sequence conflict	107 – 113	7	YMASLKG → SMDNIKR in AAB38527. Ref.2
	Sequence conflict	140	1	Q → L in AAB38527. Ref.2
	Sequence conflict	144	1	T → I in AAB38527. Ref.2
	Sequence conflict	154	1	L → M in AAB38527. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P36835 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 90022DFBB6AF78DE	FASTA	155	17,704
	10 20 30 40 50 60 MYRMQLLSCI ALTLALVANG APTSSSTGNT MKEVKSLLLD LQLLLEKVKN LENLKLSRMH 70 80 90 100 110 120 TFNFYMPKVN DTELKHLKCL LEELKLLEDV LDLAPSKNRN TREIKDYMAS LKGIVLELQG 130 140 150 SETRFTCEYD DATVKAVEFQ NKWTTFCQSI YSTLT

References

[1]	"The molecular cloning and expression of caprine interleukin 2." Rimstad E. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[2]	"Nucleotide sequence of caprine interferon-gamma, interleukin-2 and interleukin-4 cDNAs." Beyer J.C., Cheevers W.P. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76063 mRNA. Translation: CAA53664.1. U34274 mRNA. Translation: AAB38527.1.
PIR	S38662.
3D structure databases
ProteinModelPortal	P36835.
SMR	P36835. Positions 21-155.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG007496.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000779. Interleukin-2. [Graphical view]
PANTHER	PTHR11443. PTHR11443. 1 hit.
Pfam	PF00715. IL2. 1 hit. [Graphical view]
PRINTS	PR00265. INTERLEUKIN2.
ProDom	PD003649. Interleukin-2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00189. IL2. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00424. INTERLEUKIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IL2_CAPHI

Accession

Primary (citable) accession number: P36835
Secondary accession number(s): P79156

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	March 6, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program