Reviewed, UniProtKB/Swiss-Prot P36773 (LON1_MYXXA)

Names and origin

Protein names

Recommended name:
    ATP-dependent protease La 1
    EC=3.4.21.53

Gene names

Name:	lonV
Synonyms:	lon

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	817 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Degrades short-lived regulatory and abnormal proteins. May be essential for cell growth.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subcellular location	Cytoplasm.
Developmental stage	Expressed during vegetative growth.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 817	817	ATP-dependent protease La 1		PRO_0000076142
Regions
	Domain	17 – 214	198	Lon
	Nucleotide binding	368 – 375	8	ATP Potential
Sites
	Active site	691	1	By similarity
	Active site	734	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36773-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: BE2DAD65502883DF	FASTA	817	91,815
	10 20 30 40 50 60 MFFGRDDKKE AQKRGLTVPL LPLRDIIVFP HMVVPLFVGR EKSIAALKDA MAHKGPDDKA 70 80 90 100 110 120 VILLAAQKKA KTNDPTPDDI FHFGTLGHVI QLLPLPDGTV KVLVEGVRRA KVKKFHPNDA 130 140 150 160 170 180 FFMVEVEEVE EQTEKTVELE ALVRSVHSVF EAFVKLNKRI PPEMLMQVAS IDDPARLADT 190 200 210 220 230 240 IVAHLSLKLN DKQALLETES PAKRLEKLYE LMQGEIEILQ VEKKIRTRVK KQMEKTQKEY 250 260 270 280 290 300 YLNEQMQAIQ KELGERDEFK NEIQEIEEKL KNKRMSKEAT LKVKKELKKL RMMSPMSAEA 310 320 330 340 350 360 TVVRNYIDWI ISLPWYDETQ DRLDVTEAET VLNEDHYGLK KPKERILEYL AVQQLVKKLK 370 380 390 400 410 420 GPVLCFVGPP GVGKTSLARS IARATGRKFV RLSLGGVRDE AEIRGHRRTY IGAMPGKLIQ 430 440 450 460 470 480 SLKKAGSNNP VFLLDEIDKM STDFRGDPSA ALLEVLDPEQ NHTFNDHYLD LDYDLSKVMF 490 500 510 520 530 540 ICTANTMHNI PGPLQDRMEV IRIAGYTEPE KLSIARRYLI PKEQEANGLS DLKVDISDPA 550 560 570 580 590 600 LRTIIHRYTR ESGVRSLERE IGGVFRKIAR DVLKNGKRDI DVDRKMAMKF LGTPRYRYGM 610 620 630 640 650 660 AEAEDQVGIV TGLAWTELGG EILTTEATIM PGKGKLIITG KLGEVMQESA QAAMSYVRSR 670 680 690 700 710 720 AERFGIDRKV FENYDIHVHL PEGAIPKDGP SAGVTICTAL VSALTRVLIR RDVAMTGEIT 730 740 750 760 770 780 LRGRVLPIGG LKEKTLAAHR AGIKTVLIPK ANKKDLKDIP LKIRKQLRIV PVEFVDDVLR 790 800 810 EALVLEKPEE FGRKPTTDGG KLGGTTELPA SPAVAPA

References

[1]	"Cloning and nucleotide sequence of the Myxococcus xanthus lon gene: indispensability of lon for vegetative growth." Tojo N., Inouye S., Komano T. J. Bacteriol. 175:2271-2277(1993) [PubMed: 8468287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DZF1.
[2]	Ueki T., Inouye S. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DZF1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D12923 Genomic DNA. Translation: BAA02307.1. AF127082 Genomic DNA. Translation: AAD31005.1.
PIR	A49844.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S16.001.
Enzyme and pathway databases
BRENDA	3.4.21.53. 926.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR001984. Peptidase_S16_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PRINTS	PR00830. ENDOLAPTASE.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
TIGRFAMs	TIGR00763. lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON1_MYXXA

Accession

Primary (citable) accession number: P36773

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)