Reviewed, UniProtKB/Swiss-Prot P36772 (LON_BRECH)

Names and origin

Protein names

Recommended name:
    ATP-dependent protease La
    EC=3.4.21.53

Gene names

Name:

lon

Organism

Brevibacillus choshinensis

Taxonomic identifier

54911 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	779 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degrades short-lived regulatory and abnormal proteins in presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate By similarity.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 779	779	ATP-dependent protease La		PRO_0000076120
Regions
	Domain	9 – 201	193	Lon
	Nucleotide binding	355 – 362	8	ATP Potential
Sites
	Active site	678	1	By similarity
	Active site	721	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36772-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 625E0DA9B98941B5	FASTA	779	87,422
	10 20 30 40 50 60 MGERSGKREL PLLPLRGLLV YPTMVLHLDV GREKSIRALE QAMVDDNKIL LATQEEVHIE 70 80 90 100 110 120 EPDAEQIYSI GTVARVKQML KLPNGTIRVL VEGLQRAKIE EYLQKEDYFV VSITYLKEEK 130 140 150 160 170 180 AEENEVEALM RSLLTHFEQY IKLSKKVSPE TLTSVQDIEE PGRLADVIAS HLPLKMKDKQ 190 200 210 220 230 240 EILETVNIQE RLEILLTILN NEREVLELER KIGNRVKKQM ERTQKEYYLR EQMKAIQKEL 250 260 270 280 290 300 GDKDGRQGEV DELRAQLEKS DAPERIKAKI EKELERLEKM PSTSAEGSVI RTYIDTLFAL 310 320 330 340 350 360 PWTKTTEDNL DIKHAEEVLD EDHYGLEKPK ERVLEYLAVQ KLVNSMRGPI LCLVGPPGVG 370 380 390 400 410 420 KTSLARSVAR ALGREFVRIS LGGVRDEAEI RGHRRTYVGA LPGRIIQGMK QAGTINPVFL 430 440 450 460 470 480 LDEIDKLASD FRGDPASALL EVLDPNQNDK FSDHYIEETY DLTNVMFITT ANSLDTIPRP 490 500 510 520 530 540 LLDRMEVISI SGYTELEKLN ILRGYLLPKQ MEDHGLGKDK LQMNEDAMLK LVRLYTREAG 550 560 570 580 590 600 VRNLNREAAN VCRKAAKIIV GGEKKRVVVT AKTLEALLGK PRYRYGLAEK KDQVGSVTGL 610 620 630 640 650 660 AWTQAGGDTL NVEVSILAGK GKLTLTGQLG DVMKESAQAA FSYIRSRASE WGIDPEFHEK 670 680 690 700 710 720 NDIHIHVPEG AIPKDGPSAG ITMATALVSA LTGIPVKKEV GMTGEITLRG RVLPIGGLKE 730 740 750 760 770 KCMSAHRAGL TTIILPKDNE KDIEDIPESV REALTFYPVE HLDEVLRHAL TKQPVGDKK

References

[1]	"Cloning, characterization, and inactivation of the Bacillus brevis lon gene." Ito K., Udaka S., Yamagata H. J. Bacteriol. 174:2281-2287(1992) [PubMed: 1551846] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: HPD31.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D00863 Genomic DNA. Translation: BAA00737.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.4.21.53. 277212.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR001984. Peptidase_S16_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PRINTS	PR00830. ENDOLAPTASE.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
TIGRFAMs	TIGR00763. lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON_BRECH

Accession

Primary (citable) accession number: P36772

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)