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Protein

Probable HTH-type transcriptional regulator LrhA

Gene

lrhA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 47H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • bacterial-type proximal promoter sequence-specific DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: GO_Central
  • sequence-specific DNA binding Source: EcoliWiki

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12123-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator LrhA
Gene namesi
Name:lrhA
Synonyms:genR
Ordered Locus Names:b2289, JW2284
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12123 lrhA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056631 – 312Probable HTH-type transcriptional regulator LrhAAdd BLAST312

Proteomic databases

PaxDbiP36771
PRIDEiP36771

Interactioni

Protein-protein interaction databases

BioGridi4262973, 16 interactors
IntActiP36771, 1 interactor
STRINGi316385.ECDH10B_2451

Structurei

3D structure databases

ProteinModelPortaliP36771
SMRiP36771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4107NQ8 Bacteria
ENOG410XR9D LUCA
HOGENOMiHOG000233517
InParanoidiP36771
OMAiRTWRITC
PhylomeDBiP36771

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P36771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE
60 70 80 90 100
QLVGKELFAR HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV
110 120 130 140 150
LTIGASDESA DTILPFLLNR VSSVYPKLAL DVRVKRNAYM AEMLESQEVD
160 170 180 190 200
LMVTTHRPSA FKALNLRTSP THWYCAAEYI LQKGEPIPLV LLDDPSPFRD
210 220 230 240 250
MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV EMMSPDLRVL
260 270 280 290 300
SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPMSAPE
310
GDDSLLIERD IE
Length:312
Mass (Da):34,594
Last modified:November 1, 1997 - v2
Checksum:i9FC82A806CA3D11C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291 – 312WQYSP…ERDIE → CNTAQCLLRKGMIH in CAA52637 (PubMed:7565112).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74546 Genomic DNA Translation: CAA52637.1
U00096 Genomic DNA Translation: AAC75349.1
AP009048 Genomic DNA Translation: BAA16124.2
PIRiG65000
RefSeqiNP_416792.1, NC_000913.3
WP_000622280.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75349; AAC75349; b2289
BAA16124; BAA16124; BAA16124
GeneIDi946769
KEGGiecj:JW2284
eco:b2289
PATRICifig|1411691.4.peg.4446

Similar proteinsi

Entry informationi

Entry nameiLRHA_ECOLI
AccessioniPrimary (citable) accession number: P36771
Secondary accession number(s): P76490, P76934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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