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Protein

Probable HTH-type transcriptional regulator LrhA

Gene

lrhA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 4720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12123-MONOMER.
ECOL316407:JW2284-MONOMER.
RETL1328306-WGS:GSTH-2522-MONOMER.
RETL1328306-WGS:GSTH-3606-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator LrhA
Gene namesi
Name:lrhA
Synonyms:genR
Ordered Locus Names:b2289, JW2284
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12123. lrhA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Probable HTH-type transcriptional regulator LrhAPRO_0000105663Add
BLAST

Proteomic databases

PaxDbiP36771.

Interactioni

Protein-protein interaction databases

BioGridi4262973. 16 interactions.
IntActiP36771. 1 interaction.
STRINGi511145.b2289.

Structurei

3D structure databases

ProteinModelPortaliP36771.
SMRiP36771. Positions 11-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6858HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107NQ8. Bacteria.
ENOG410XR9D. LUCA.
HOGENOMiHOG000233517.
InParanoidiP36771.
OMAiASLEAPC.
PhylomeDBiP36771.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE
60 70 80 90 100
QLVGKELFAR HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV
110 120 130 140 150
LTIGASDESA DTILPFLLNR VSSVYPKLAL DVRVKRNAYM AEMLESQEVD
160 170 180 190 200
LMVTTHRPSA FKALNLRTSP THWYCAAEYI LQKGEPIPLV LLDDPSPFRD
210 220 230 240 250
MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV EMMSPDLRVL
260 270 280 290 300
SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPMSAPE
310
GDDSLLIERD IE
Length:312
Mass (Da):34,594
Last modified:November 1, 1997 - v2
Checksum:i9FC82A806CA3D11C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 31222WQYSP…ERDIE → CNTAQCLLRKGMIH in CAA52637 (PubMed:7565112).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74546 Genomic DNA. Translation: CAA52637.1.
U00096 Genomic DNA. Translation: AAC75349.1.
AP009048 Genomic DNA. Translation: BAA16124.2.
PIRiG65000.
RefSeqiNP_416792.1. NC_000913.3.
WP_000622280.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75349; AAC75349; b2289.
BAA16124; BAA16124; BAA16124.
GeneIDi946769.
KEGGiecj:JW2284.
eco:b2289.
PATRICi32119945. VBIEscCol129921_2382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74546 Genomic DNA. Translation: CAA52637.1.
U00096 Genomic DNA. Translation: AAC75349.1.
AP009048 Genomic DNA. Translation: BAA16124.2.
PIRiG65000.
RefSeqiNP_416792.1. NC_000913.3.
WP_000622280.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36771.
SMRiP36771. Positions 11-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262973. 16 interactions.
IntActiP36771. 1 interaction.
STRINGi511145.b2289.

Proteomic databases

PaxDbiP36771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75349; AAC75349; b2289.
BAA16124; BAA16124; BAA16124.
GeneIDi946769.
KEGGiecj:JW2284.
eco:b2289.
PATRICi32119945. VBIEscCol129921_2382.

Organism-specific databases

EchoBASEiEB2044.
EcoGeneiEG12123. lrhA.

Phylogenomic databases

eggNOGiENOG4107NQ8. Bacteria.
ENOG410XR9D. LUCA.
HOGENOMiHOG000233517.
InParanoidiP36771.
OMAiASLEAPC.
PhylomeDBiP36771.

Enzyme and pathway databases

BioCyciEcoCyc:EG12123-MONOMER.
ECOL316407:JW2284-MONOMER.
RETL1328306-WGS:GSTH-2522-MONOMER.
RETL1328306-WGS:GSTH-3606-MONOMER.

Miscellaneous databases

PROiP36771.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRHA_ECOLI
AccessioniPrimary (citable) accession number: P36771
Secondary accession number(s): P76490, P76934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.