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Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 49
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Minor capsid protein L2UniRule annotation
Gene namesi
Name:L2UniRule annotation
OrganismiHuman papillomavirus type 49
Taxonomic identifieri10616 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009124 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001336151 – 521Minor capsid protein L2Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 25UniRule annotation

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with major capsid protein L1. Interacts with E2; this interaction inhibits E2 transcriptional activity but not the DNA replication function E2. Interacts with host HSPA8; this interaction is required for L2 nuclear translocation. Interacts with host importins KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1 heterodimers via interaction with the importin alpha2 adapter. Interacts with host DYNLT1; this interaction is essential for virus intracellular transport during entry.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 10Nuclear localization signalUniRule annotation10
Motifi513 – 520Nuclear localization signalUniRule annotation8

Sequence similaritiesi

Belongs to the papillomaviridae L2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000CV.

Family and domain databases

HAMAPiMF_04003. PPV_L2. 1 hit.
InterProiView protein in InterPro
IPR000784. Late_L2.
PfamiView protein in Pfam
PF00513. Late_protein_L2. 1 hit.

Sequencei

Sequence statusi: Complete.

P36762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRARRTKRD SVTNIYRTCK QAGNCPPDVV NKVEQTTIAD QILKFGSTGV
60 70 80 90 100
FFGGLGIGTG RGTGGSTGYV PIGEGPAIRV GGTPSVVRPG ILPEAIGPAD
110 120 130 140 150
IIPIDTVNPI DPNASSVVPL TDTGPDLLPG TIETIAEVNP APDIPRVDTS
160 170 180 190 200
VVTTSRGSSA VLEVASEPTP PTRTRISRTQ YHNPSFQILT ESTPSLGESA
210 220 230 240 250
LTDHVVVTSG SGGQPIGGVT PVEIELQELP SRYTFEIEEP TPPRRSSTPL
260 270 280 290 300
RNITQAVGNL RRSLYNRRLT QQVNVQDPLF LQQPSRLVRF AFDNPVFEEE
310 320 330 340 350
VTQIFERDVA AVEEPPDRDF LDIAKLSRPL YSETPQGYVR VSRLGNRASI
360 370 380 390 400
RTRSGATVGA QVHFYTDLST IDAEESIELS LLGEHSGDAT IVQGPVESSF
410 420 430 440 450
VDLNVQELPQ VIEVDPEPTF HSDDLLLDEQ NEDFSGSQLV YGSGRRSTTF
460 470 480 490 500
TVPRFSTPRS DTFYVQDLEG YAVSYPERRN YPEIIYPQPD LPTVIIHTAD
510 520
TSGDFYLHPS LRRRKRKRTY L
Length:521
Mass (Da):57,055
Last modified:June 1, 1994 - v1
Checksum:i3DFB43327FB2E5C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74480 Genomic DNA. Translation: CAA52583.1.
PIRiS36571.
RefSeqiNP_041836.1. NC_001591.1.

Genome annotation databases

GeneIDi1489447.
KEGGivg:1489447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74480 Genomic DNA. Translation: CAA52583.1.
PIRiS36571.
RefSeqiNP_041836.1. NC_001591.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489447.
KEGGivg:1489447.

Phylogenomic databases

OrthoDBiVOG090000CV.

Family and domain databases

HAMAPiMF_04003. PPV_L2. 1 hit.
InterProiView protein in InterPro
IPR000784. Late_L2.
PfamiView protein in Pfam
PF00513. Late_protein_L2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVL2_HPV49
AccessioniPrimary (citable) accession number: P36762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 15, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.