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P36740 (VL1_HPV40) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major capsid protein L1
Gene names
Name:L1
OrganismHuman papillomavirus type 40 [Complete proteome]
Taxonomic identifier10615 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.

Subunit structure

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the papillomaviridae L1 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Major capsid protein L1
PRO_0000133524

Sequences

Sequence LengthMass (Da)Tools
P36740 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 7D88D4162C8A48E1

FASTA50556,376
        10         20         30         40         50         60 
MWQLNENQVY LPPPTPVATI VSTDEYVQRT SLYYHAGSAR LLTIGHPYFE LKKPNGDISV 

        70         80         90        100        110        120 
PKVSGHQYRV FRVRLPDPNK FGLSDTSLFN SETQRLVWAC VGVEVGRGQP LGVGVSGHPY 

       130        140        150        160        170        180 
FNKDEDVENS SAYGTGPGQD SRENVAMDYK QTQLCMLGCT PPIGEYWGKG TPCNASRVTL 

       190        200        210        220        230        240 
GDCPVLELKT EVIQDGDMVD TGFGAMDFAS LQANKSDVPL DLCTSISKYP DYLGMAAEPY 

       250        260        270        280        290        300 
GNSLFFFLRR EQMFVRHFFN RAGTTGDSVP TDLYITGTSG RTPIAGSIYY STPSGSLVTS 

       310        320        330        340        350        360 
DSQIFNKPLW IQKAQGHNNG ICFGNQLFVT VVDTTRSTNL TLCAATQSPT PTPYNNSNFK 

       370        380        390        400        410        420 
EYLRHGEEFD LQFIFQLCVI TLNAEVMTYI HAMDPTLLED WNFKIAPPAS ASLEDTYRFL 

       430        440        450        460        470        480 
TNKAIACQRD APPKVREDPY KKYKFWDVNL TERFSSQLDQ FPLGRKFLMQ AGVRAGPRFK 

       490        500 
SRKRPAPSSS SSSKPVTPKR KKTKR 

« Hide

References

[1]"Primer-directed sequencing of human papillomavirus types."
Delius H., Hofmann B.
Curr. Top. Microbiol. Immunol. 186:13-31(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74478 Genomic DNA. Translation: CAA52572.1.
PIRS36560.

3D structure databases

ProteinModelPortalP36740.
SMRP36740. Positions 20-473.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.175.20. 1 hit.
InterProIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSPR00865. HPVCAPSIDL1.
SUPFAMSSF88648. SSF88648. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVL1_HPV40
AccessionPrimary (citable) accession number: P36740
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families