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P36740

- VL1_HPV40

UniProt

P36740 - VL1_HPV40

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Protein
Major capsid protein L1
Gene
L1
Organism
Human papillomavirus type 40
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1
Gene namesi
Name:L1
OrganismiHuman papillomavirus type 40
Taxonomic identifieri10615 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009121: Genome

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. T=7 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Major capsid protein L1
PRO_0000133524Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.

Structurei

3D structure databases

ProteinModelPortaliP36740.
SMRiP36740. Positions 20-473.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
InterProiIPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view]
PfamiPF00500. Late_protein_L1. 1 hit.
[Graphical view]
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

P36740-1 [UniParc]FASTAAdd to Basket

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MWQLNENQVY LPPPTPVATI VSTDEYVQRT SLYYHAGSAR LLTIGHPYFE    50
LKKPNGDISV PKVSGHQYRV FRVRLPDPNK FGLSDTSLFN SETQRLVWAC 100
VGVEVGRGQP LGVGVSGHPY FNKDEDVENS SAYGTGPGQD SRENVAMDYK 150
QTQLCMLGCT PPIGEYWGKG TPCNASRVTL GDCPVLELKT EVIQDGDMVD 200
TGFGAMDFAS LQANKSDVPL DLCTSISKYP DYLGMAAEPY GNSLFFFLRR 250
EQMFVRHFFN RAGTTGDSVP TDLYITGTSG RTPIAGSIYY STPSGSLVTS 300
DSQIFNKPLW IQKAQGHNNG ICFGNQLFVT VVDTTRSTNL TLCAATQSPT 350
PTPYNNSNFK EYLRHGEEFD LQFIFQLCVI TLNAEVMTYI HAMDPTLLED 400
WNFKIAPPAS ASLEDTYRFL TNKAIACQRD APPKVREDPY KKYKFWDVNL 450
TERFSSQLDQ FPLGRKFLMQ AGVRAGPRFK SRKRPAPSSS SSSKPVTPKR 500
KKTKR 505
Length:505
Mass (Da):56,376
Last modified:June 1, 1994 - v1
Checksum:i7D88D4162C8A48E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74478 Genomic DNA. Translation: CAA52572.1.
PIRiS36560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74478 Genomic DNA. Translation: CAA52572.1 .
PIRi S36560.

3D structure databases

ProteinModelPortali P36740.
SMRi P36740. Positions 20-473.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.175.20. 1 hit.
InterProi IPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
[Graphical view ]
Pfami PF00500. Late_protein_L1. 1 hit.
[Graphical view ]
PRINTSi PR00865. HPVCAPSIDL1.
SUPFAMi SSF88648. SSF88648. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Primer-directed sequencing of human papillomavirus types."
    Delius H., Hofmann B.
    Curr. Top. Microbiol. Immunol. 186:13-31(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVL1_HPV40
AccessioniPrimary (citable) accession number: P36740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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