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P36740

- VL1_HPV40

UniProt

P36740 - VL1_HPV40

Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 40
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major capsid protein L1
    Gene namesi
    Name:L1
    OrganismiHuman papillomavirus type 40
    Taxonomic identifieri10615 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009121: Genome

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. T=7 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, T=7 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Major capsid protein L1PRO_0000133524Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP36740.
    SMRiP36740. Positions 20-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the papillomaviridae L1 protein family.Curated

    Family and domain databases

    Gene3Di2.60.175.20. 1 hit.
    InterProiIPR002210. Capsid_L1_Papillomavir.
    IPR011222. dsDNA_vir_gr_I_capsid.
    [Graphical view]
    PfamiPF00500. Late_protein_L1. 1 hit.
    [Graphical view]
    PRINTSiPR00865. HPVCAPSIDL1.
    SUPFAMiSSF88648. SSF88648. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P36740-1 [UniParc]FASTAAdd to Basket

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    MWQLNENQVY LPPPTPVATI VSTDEYVQRT SLYYHAGSAR LLTIGHPYFE    50
    LKKPNGDISV PKVSGHQYRV FRVRLPDPNK FGLSDTSLFN SETQRLVWAC 100
    VGVEVGRGQP LGVGVSGHPY FNKDEDVENS SAYGTGPGQD SRENVAMDYK 150
    QTQLCMLGCT PPIGEYWGKG TPCNASRVTL GDCPVLELKT EVIQDGDMVD 200
    TGFGAMDFAS LQANKSDVPL DLCTSISKYP DYLGMAAEPY GNSLFFFLRR 250
    EQMFVRHFFN RAGTTGDSVP TDLYITGTSG RTPIAGSIYY STPSGSLVTS 300
    DSQIFNKPLW IQKAQGHNNG ICFGNQLFVT VVDTTRSTNL TLCAATQSPT 350
    PTPYNNSNFK EYLRHGEEFD LQFIFQLCVI TLNAEVMTYI HAMDPTLLED 400
    WNFKIAPPAS ASLEDTYRFL TNKAIACQRD APPKVREDPY KKYKFWDVNL 450
    TERFSSQLDQ FPLGRKFLMQ AGVRAGPRFK SRKRPAPSSS SSSKPVTPKR 500
    KKTKR 505
    Length:505
    Mass (Da):56,376
    Last modified:June 1, 1994 - v1
    Checksum:i7D88D4162C8A48E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74478 Genomic DNA. Translation: CAA52572.1.
    PIRiS36560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74478 Genomic DNA. Translation: CAA52572.1 .
    PIRi S36560.

    3D structure databases

    ProteinModelPortali P36740.
    SMRi P36740. Positions 20-473.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.175.20. 1 hit.
    InterProi IPR002210. Capsid_L1_Papillomavir.
    IPR011222. dsDNA_vir_gr_I_capsid.
    [Graphical view ]
    Pfami PF00500. Late_protein_L1. 1 hit.
    [Graphical view ]
    PRINTSi PR00865. HPVCAPSIDL1.
    SUPFAMi SSF88648. SSF88648. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primer-directed sequencing of human papillomavirus types."
      Delius H., Hofmann B.
      Curr. Top. Microbiol. Immunol. 186:13-31(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiVL1_HPV40
    AccessioniPrimary (citable) accession number: P36740
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3