P36716 (PEN3_ADE12) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Penton protein

Alternative name(s):
Penton base protein
Virion component III
pIII

Gene names

Name:

PIII

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in virus clathrin-mediated internalization through the binding to host integrin heterodimer alphaV-beta5 (ITGAV-ITGB5). In primary receptor (CXADR)-negative cells, also mediates virus attachment to host cell By similarity.
Subunit structure	Interacts with host WWP1 and WWP2. Interacts (via cell attachment site RGD) with host heterodimer ITGAV-ITGB5 By similarity.
Sequence similarities	Belongs to the adenoviridae pIII family.

Ontologies

Keywords
Biological process	Clathrin-mediated endocytosis of virus by host Host-virus interaction Initiation of viral infection Viral attachment to host cell Viral penetration into host cytoplasm Virus endocytosis by host
Developmental stage	Late protein
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Penton protein		PRO_0000221874

Sequences

	Sequence		Length	Mass (Da)
	P36716 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 0524D989F5A9ED13	FASTA	497	56,394
	10 20 30 40 50 60 MRRAVELQTV AFPETPPPSY ETVMAAAPPY VPPRYLGPTE GRNSIRYSEL SPLYDTTRVY 70 80 90 100 110 120 LVDNKSSDIA SLNYQNDHSN FLTTVVQNND YSPIEAGTQT INFDERSRWG GDLKTILHTN 130 140 150 160 170 180 MPNVNDFMFT TKFKARVMVA RKTNNEGQTI LEYEWAEFVL PEGNYSETMT IDLMNNAIIE 190 200 210 220 230 240 HYLRVGRQHG VLESDIGVKF DTRNFRLGWD PETQLVTPGV YTNEAFHPDI VLLPGCGVDF 250 260 270 280 290 300 TESRLSNILG IRKRQPFQEG FVIMYEHLEG GNIPALLDVK KYENSLQDQN TVRGDNFIAL 310 320 330 340 350 360 NKAARIEPVE TDPKGRSYNL LPDKKNTKYR SWYLAYNYGD PEKGVRSWTL LTTPDVTGGS 370 380 390 400 410 420 EQVYWSLPDM MQDPVTFRSS RQVSNYPVVA AELLPVHAKS FYNEQAVYSQ LIRQSTALTR 430 440 450 460 470 480 VFNRFPENQI LVRPPAATIT TVSENVPALT DHGTLPLRSS ISGVQRVTIT DARRRTCPYV 490 YKALGIVSPR VLSSRTF

References

[1]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73487 Genomic DNA. Translation: CAA51887.1.
PIR	S33938.
RefSeq	NP_040920.1. NC_001460.1.
3D structure databases
ProteinModelPortal	P36716.
SMR	P36716. Positions 39-495.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1460868.
Phylogenomic databases
ProtClustDB	CLSP2513879.
Family and domain databases
InterPro	IPR002605. Adeno_Penton_B. [Graphical view]
Pfam	PF01686. Adeno_Penton_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PEN3_ADE12

Accession

Primary (citable) accession number: P36716

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 5, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program