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Reviewed, UniProtKB/Swiss-Prot P36711 (FIBP_ADE12)

Last modified January 19, 2010. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fiber protein
Alternative name(s):
    pIV
Gene names
Name: PIV
OrganismHuman adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
Taxonomic identifier28282 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A
Virus hostHomo sapiens (Human) [TaxID: 9606]

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Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Recognizes the cell receptor; serves as the ligand between the adenovirus capsid and the host cell receptor.

Subunit structure

Homotrimer. Interacts with the cell receptor CXADR.

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Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentFiber protein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processcell adhesion

Inferred from electronic annotation. Source: InterPro

cell recognition

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

viral infectious cycle

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Fiber protein
PRO_0000221795

Experimental info

Mutagenesis4171P → E: Loss of interaction with CXADR. Ref.2
Mutagenesis4181P → E: Loss of interaction with CXADR. Ref.2
Mutagenesis4211S → TIS: Loss of interaction with CXADR. Ref.2
Mutagenesis4251Missing: Loss of interaction with CXADR. Ref.2
Mutagenesis4261Missing: Loss of interaction with CXADR. Ref.2
Mutagenesis5501Missing: Loss of interaction with CXADR. Ref.2
Mutagenesis5511Missing: Loss of interaction with CXADR. Ref.2

Secondary structure

1 ................................... 587
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P36711-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 6D285B5B61008A4C

FASTA58761,699
        10         20         30         40         50         60 
MKRSRTQYAE ETEENDDFNP VYPFDPFDTS DVPFVTPPFT SSNGLQEKPP GVLALNYKDP 

        70         80         90        100        110        120 
IVTENGTLTL KLGDGIKLNA QGQLTASNNI NVLEPLTNTS QGLKLSWSAP LAVKASALTL 

       130        140        150        160        170        180 
NTRAPLTTTD ESLALITAPP ITVESSRLGL ATIAPLSLDG GGNLGLNLSA PLDVSNNNLH 

       190        200        210        220        230        240 
LTTETPLVVN SSGALSVATA DPISVRNNAL TLPTADPLMV SSDGLGISVT SPITVINGSL 

       250        260        270        280        290        300 
ALSTTAPLNS TGSTLSLSVA NPLTISQDTL TVSTGNGLQV SGSQLVTRIG DGLTFDNGVM 

       310        320        330        340        350        360 
KVNVAGGMRT SGGRIILDVN YPFDASNNLS LRRGLGLIYN QSTNWNLTTD ISTEKGLMFS 

       370        380        390        400        410        420 
GNQIALNAGQ GLTFNNGQLR VKLGAGLIFD SNNNIALGSS SNTPYDPLTL WTTPDPPPNC 

       430        440        450        460        470        480 
SLIQELDAKL TLCLTKNGSI VNGIVSLVGV KGNLLNIQST TTTVGVHLVF DEQGRLITST 

       490        500        510        520        530        540 
PTALVPQASW GYRQGQSVST NTVTNGLGFM PNVSAYPRPN ASEAKSQMVS LTYLQGDTSK 

       550        560        570        580 
PITMKVAFNG ITSLNGYSLT FMWSGLSNYI NQPFSTPSCS FSYITQE

« Hide

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis."
Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W.
J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR."
Bewley M.C., Springer K., Zhang Y.-B., Freimuth P., Flanagan J.M.
Science 286:1579-1583(1999) [PubMed: 10567268] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 403-587 IN COMPLEX WITH CXADR, MUTAGENESIS OF PRO-417; PRO-418; SER-421; GLU-425; LEU-426; GLY-550 AND ILE-551.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X73487 Genomic DNA. Translation: CAA51900.1.
PIRS33951.
RefSeqNP_040933.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KACX-ray2.60A403-587[»]
1NOBX-ray2.60A/B/C/D/E/F403-587[»]
1P69X-ray3.10A403-587[»]
1P6AX-ray2.90A403-587[»]
ModBaseSearch...

Genome annotation databases

GeneID1460847.

Family and domain databases

InterProIPR000978. Adeno_fiber_knob.
IPR000931. Adeno_fibre.
IPR000939. Adenobir_fiber_prot_rpt/shaft.
IPR008982. Viral_att.
IPR009013. Viral_attachment_fibre_shaft.
[Graphical view]
Gene3DG3DSA:2.60.90.10. Adeno_fiber_knob. 1 hit.
PfamPF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 7 hits.
[Graphical view]
PRINTSPR00307. ADENOVSFIBRE.
ProtoNetSearch...

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Entry information

Entry nameFIBP_ADE12
AccessionPrimary (citable) accession number: P36711
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 19, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents