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Protein

Cell division protein ZapD

Gene

zapD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.UniRule annotation1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • FtsZ-dependent cytokinesis Source: EcoCyc

Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:EG12313-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapDUniRule annotation
Alternative name(s):
Z ring-associated protein DUniRule annotation
Gene namesi
Name:zapDUniRule annotation
Synonyms:yacF
Ordered Locus Names:b0102, JW0099
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12313 zapD

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Note: Localizes to mid-cell in an FtsZ-dependent manner. Localization does not require FtsA, ZipA, ZapA or ZapC.

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants are viable, with no discernible division phenotypes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002116671 – 247Cell division protein ZapDAdd BLAST247

Proteomic databases

PaxDbiP36680
PRIDEiP36680

Interactioni

Subunit structurei

Mostly homodimer in solution. Interacts with the C-terminal tail of FtsZ.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260784, 3 interactors
IntActiP36680, 5 interactors
STRINGi316385.ECDH10B_0083

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi13 – 28Combined sources16
Helixi37 – 55Combined sources19
Helixi59 – 76Combined sources18
Beta strandi78 – 80Combined sources3
Helixi85 – 104Combined sources20
Helixi110 – 114Combined sources5
Helixi116 – 124Combined sources9
Turni128 – 131Combined sources4
Turni133 – 135Combined sources3
Helixi137 – 142Combined sources6
Helixi147 – 159Combined sources13
Helixi162 – 175Combined sources14
Beta strandi182 – 187Combined sources6
Beta strandi190 – 194Combined sources5
Beta strandi199 – 204Combined sources6
Helixi207 – 209Combined sources3
Beta strandi211 – 218Combined sources8
Beta strandi221 – 233Combined sources13
Beta strandi240 – 246Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DKOX-ray2.40A1-247[»]
5IMJX-ray3.10A/B2-247[»]
5KOAX-ray2.67A/B2-247[»]
ProteinModelPortaliP36680
SMRiP36680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZapD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHA Bacteria
COG4582 LUCA
HOGENOMiHOG000283874
KOiK18778
OMAiLPAYYAW

Family and domain databases

Gene3Di2.60.440.10, 1 hit
HAMAPiMF_01092 ZapD, 1 hit
InterProiView protein in InterPro
IPR009777 ZapD
IPR027462 ZapD_C
IPR036268 ZapD_sf
PANTHERiPTHR39455 PTHR39455, 1 hit
PfamiView protein in Pfam
PF07072 ZapD, 1 hit
SUPFAMiSSF160950 SSF160950, 1 hit

Sequencei

Sequence statusi: Complete.

P36680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTQVLFEHP LNEKMRTWLR IEFLIQQLTV NLPIVDHAGA LHFFRNVSEL
60 70 80 90 100
LDVFERGEVR TELLKELDRQ QRKLQTWIGV PGVDQSRIEA LIQQLKAAGS
110 120 130 140 150
VLISAPRIGQ FLREDRLIAL VRQRLSIPGG CCSFDLPTLH IWLHLPQAQR
160 170 180 190 200
DSQVETWIAS LNPLTQALTM VLDLIRQSAP FRKQTSLNGF YQDNGGDADL
210 220 230 240
LRLNLSLDSQ LYPQISGHKS RFAIRFMPLD TENGQVPERL DFELACC
Length:247
Mass (Da):28,292
Last modified:November 1, 1997 - v2
Checksum:i3C0B917A7FA844AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215I → T no nucleotide entry (PubMed:8202364).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73213.1
AP009048 Genomic DNA Translation: BAB96671.2
PIRiF64732
RefSeqiNP_414644.1, NC_000913.3
WP_001194734.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73213; AAC73213; b0102
BAB96671; BAB96671; BAB96671
GeneIDi944873
KEGGiecj:JW0099
eco:b0102
PATRICifig|1411691.4.peg.2179

Similar proteinsi

Entry informationi

Entry nameiZAPD_ECOLI
AccessioniPrimary (citable) accession number: P36680
Secondary accession number(s): P75645, Q8KJQ6, Q8KMZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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