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Protein

HTH-type transcriptional regulator TreR

Gene

treR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repressor of the treBC operon. It is able to bind trehalose-6-phosphate and trehalose.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126Trehalose-6-phosphate; via carbonyl oxygen1 Publication1
Binding sitei147Trehalose-6-phosphate1 Publication1
Binding sitei194Trehalose-6-phosphate1 Publication1
Binding sitei242Trehalose-6-phosphate1 Publication1
Binding sitei284Trehalose-6-phosphate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 26H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12202-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator TreR1 Publication
Alternative name(s):
Trehalose operon repressor1 Publication
Gene namesi
Name:treR
Ordered Locus Names:b4241, JW4200
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12202 treR

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are constitutive in the expression of the treBC operon.1 Publication

Chemistry databases

DrugBankiDB02430 Trehalose-6-Phosphate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080051 – 315HTH-type transcriptional regulator TreRAdd BLAST315

Proteomic databases

PaxDbiP36673
PRIDEiP36673

Expressioni

Inductioni

Probably induced by trehalose-6-phosphate.1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi4260956, 12 interactors
DIPiDIP-11026N
IntActiP36673, 10 interactors
STRINGi316385.ECDH10B_4436

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi64 – 70Combined sources7
Helixi75 – 91Combined sources17
Beta strandi94 – 99Combined sources6
Helixi104 – 116Combined sources13
Beta strandi120 – 125Combined sources6
Turni132 – 135Combined sources4
Helixi136 – 138Combined sources3
Beta strandi141 – 147Combined sources7
Beta strandi152 – 157Combined sources6
Helixi159 – 172Combined sources14
Beta strandi178 – 181Combined sources4
Turni188 – 191Combined sources4
Helixi192 – 204Combined sources13
Beta strandi210 – 212Combined sources3
Helixi218 – 224Combined sources7
Helixi225 – 228Combined sources4
Beta strandi235 – 240Combined sources6
Helixi241 – 253Combined sources13
Beta strandi260 – 264Combined sources5
Helixi268 – 273Combined sources6
Beta strandi277 – 281Combined sources5
Helixi284 – 299Combined sources16
Beta strandi307 – 310Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XXHX-ray2.40A/B61-315[»]
ProteinModelPortaliP36673
SMRiP36673
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36673

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 59HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 77Trehalose-6-phosphate binding1 Publication7
Regioni187 – 190Trehalose-6-phosphate binding1 Publication4

Phylogenomic databases

eggNOGiENOG4105D4X Bacteria
COG1609 LUCA
HOGENOMiHOG000283706
KOiK03485
OMAiHRHISFL
PhylomeDBiP36673

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR028082 Peripla_BP_I
IPR012771 Trehalos_R_gpbac
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PRINTSiPR00036 HTHLACI
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
TIGRFAMsiTIGR02405 trehalos_R_Ecol, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNRLTIKDI ARLSGVGKST VSRVLNNESG VSQLTRERVE AVMNQHGFSP
60 70 80 90 100
SRSARAMRGQ SDKVVAIIVT RLDSLSENLA VQTMLPAFYE QGYDPIMMES
110 120 130 140 150
QFSPQLVAEH LGVLKRRNID GVVLFGFTGI TEEMLAHWQS SLVLLARDAK
160 170 180 190 200
GFASVCYDDE GAIKILMQRL YDQGHRNISY LGVPHSDVTT GKRRHEAYLA
210 220 230 240 250
FCKAHKLHPV AALPGLAMKQ GYENVAKVIT PETTALLCAT DTLALGASKY
260 270 280 290 300
LQEQRIDTLQ LASVGNTPLM KFLHPEIVTV DPGYAEAGRQ AACQLIAQVT
310
GRSEPQQIII PATLS
Length:315
Mass (Da):34,531
Last modified:February 1, 1995 - v2
Checksum:i16C528EBDE40C665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07790 Unassigned DNA Translation: AAB47715.1
U14003 Genomic DNA Translation: AAA97138.1
U00096 Genomic DNA Translation: AAC77198.1
AP009048 Genomic DNA Translation: BAE78240.1
U06195 Genomic DNA No translation available.
PIRiS56467
RefSeqiNP_418662.1, NC_000913.3
WP_001181307.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77198; AAC77198; b4241
BAE78240; BAE78240; BAE78240
GeneIDi948760
KEGGiecj:JW4200
eco:b4241
PATRICifig|1411691.4.peg.2460

Similar proteinsi

Entry informationi

Entry nameiTRER_ECOLI
AccessioniPrimary (citable) accession number: P36673
Secondary accession number(s): Q2M666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health