Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator TreR

Gene

treR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the treBC operon. It is able to bind trehalose-6-phosphate and trehalose.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126Trehalose-6-phosphate; via carbonyl oxygen1 Publication1
Binding sitei147Trehalose-6-phosphate1 Publication1
Binding sitei194Trehalose-6-phosphate1 Publication1
Binding sitei242Trehalose-6-phosphate1 Publication1
Binding sitei284Trehalose-6-phosphate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 26H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12202-MONOMER.
ECOL316407:JW4200-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator TreR1 Publication
Alternative name(s):
Trehalose operon repressor1 Publication
Gene namesi
Name:treR
Ordered Locus Names:b4241, JW4200
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12202. treR.

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are constitutive in the expression of the treBC operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080051 – 315HTH-type transcriptional regulator TreRAdd BLAST315

Proteomic databases

PaxDbiP36673.
PRIDEiP36673.

Expressioni

Inductioni

Probably induced by trehalose-6-phosphate.1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi4260956. 9 interactors.
DIPiDIP-11026N.
IntActiP36673. 10 interactors.
STRINGi511145.b4241.

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi64 – 70Combined sources7
Helixi75 – 91Combined sources17
Beta strandi94 – 99Combined sources6
Helixi104 – 116Combined sources13
Beta strandi120 – 125Combined sources6
Turni132 – 135Combined sources4
Helixi136 – 138Combined sources3
Beta strandi141 – 147Combined sources7
Beta strandi152 – 157Combined sources6
Helixi159 – 172Combined sources14
Beta strandi178 – 181Combined sources4
Turni188 – 191Combined sources4
Helixi192 – 204Combined sources13
Beta strandi210 – 212Combined sources3
Helixi218 – 224Combined sources7
Helixi225 – 228Combined sources4
Beta strandi235 – 240Combined sources6
Helixi241 – 253Combined sources13
Beta strandi260 – 264Combined sources5
Helixi268 – 273Combined sources6
Beta strandi277 – 281Combined sources5
Helixi284 – 299Combined sources16
Beta strandi307 – 310Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XXHX-ray2.40A/B61-315[»]
ProteinModelPortaliP36673.
SMRiP36673.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36673.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 59HTH lacI-typePROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 77Trehalose-6-phosphate binding1 Publication7
Regioni187 – 190Trehalose-6-phosphate binding1 Publication4

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105D4X. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000283706.
KOiK03485.
OMAiFGFTGCD.
PhylomeDBiP36673.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR012771. Trehalos_R_gpbac.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR02405. trehalos_R_Ecol. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNRLTIKDI ARLSGVGKST VSRVLNNESG VSQLTRERVE AVMNQHGFSP
60 70 80 90 100
SRSARAMRGQ SDKVVAIIVT RLDSLSENLA VQTMLPAFYE QGYDPIMMES
110 120 130 140 150
QFSPQLVAEH LGVLKRRNID GVVLFGFTGI TEEMLAHWQS SLVLLARDAK
160 170 180 190 200
GFASVCYDDE GAIKILMQRL YDQGHRNISY LGVPHSDVTT GKRRHEAYLA
210 220 230 240 250
FCKAHKLHPV AALPGLAMKQ GYENVAKVIT PETTALLCAT DTLALGASKY
260 270 280 290 300
LQEQRIDTLQ LASVGNTPLM KFLHPEIVTV DPGYAEAGRQ AACQLIAQVT
310
GRSEPQQIII PATLS
Length:315
Mass (Da):34,531
Last modified:February 1, 1995 - v2
Checksum:i16C528EBDE40C665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07790 Unassigned DNA. Translation: AAB47715.1.
U14003 Genomic DNA. Translation: AAA97138.1.
U00096 Genomic DNA. Translation: AAC77198.1.
AP009048 Genomic DNA. Translation: BAE78240.1.
U06195 Genomic DNA. No translation available.
PIRiS56467.
RefSeqiNP_418662.1. NC_000913.3.
WP_001181307.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77198; AAC77198; b4241.
BAE78240; BAE78240; BAE78240.
GeneIDi948760.
KEGGiecj:JW4200.
eco:b4241.
PATRICi32124057. VBIEscCol129921_4373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07790 Unassigned DNA. Translation: AAB47715.1.
U14003 Genomic DNA. Translation: AAA97138.1.
U00096 Genomic DNA. Translation: AAC77198.1.
AP009048 Genomic DNA. Translation: BAE78240.1.
U06195 Genomic DNA. No translation available.
PIRiS56467.
RefSeqiNP_418662.1. NC_000913.3.
WP_001181307.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XXHX-ray2.40A/B61-315[»]
ProteinModelPortaliP36673.
SMRiP36673.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260956. 9 interactors.
DIPiDIP-11026N.
IntActiP36673. 10 interactors.
STRINGi511145.b4241.

Proteomic databases

PaxDbiP36673.
PRIDEiP36673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77198; AAC77198; b4241.
BAE78240; BAE78240; BAE78240.
GeneIDi948760.
KEGGiecj:JW4200.
eco:b4241.
PATRICi32124057. VBIEscCol129921_4373.

Organism-specific databases

EchoBASEiEB2118.
EcoGeneiEG12202. treR.

Phylogenomic databases

eggNOGiENOG4105D4X. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000283706.
KOiK03485.
OMAiFGFTGCD.
PhylomeDBiP36673.

Enzyme and pathway databases

BioCyciEcoCyc:EG12202-MONOMER.
ECOL316407:JW4200-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36673.
PROiP36673.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR012771. Trehalos_R_gpbac.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR02405. trehalos_R_Ecol. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRER_ECOLI
AccessioniPrimary (citable) accession number: P36673
Secondary accession number(s): Q2M666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.