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Protein

Rhamnosyltransferase WbbL

Gene

wbbL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Rhamnosyltransferase involved in lipopolysaccharide biosynthesis.1 Publication

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

  • transferase activity, transferring glycosyl groups Source: GO_Central
  • transferase activity, transferring hexosyl groups Source: UniProtKB

GO - Biological processi

  • extracellular polysaccharide biosynthetic process Source: UniProtKB
  • lipopolysaccharide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11986-MONOMER.
BRENDAi2.4.1.289. 2026.
UniPathwayiUPA00030.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhamnosyltransferase WbbL (EC:2.4.1.-)
Gene namesi
Name:wbbL
Ordered Locus Names:b4571, JW2016
ORF Names:b2031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11986. wbbL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Rhamnosyltransferase WbbLPRO_0000059231Add
BLAST

Proteomic databases

PRIDEiP36667.

Interactioni

Protein-protein interaction databases

IntActiP36667. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP36667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

HOGENOMiHOG000224390.
InParanoidiP36667.
PhylomeDBiP36667.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

P36667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYIIIVSHG HEDYIKKLLE NLNADDEHYK IIVRDNKDSL LLKQICQHYA
60 70 80 90 100
GLDYISGGVY GFGHNNNIAV AYVKEKYRPA DDDYILFLNP DIIMKHDDLL
110 120 130 140 150
TYIKYVESKR YAFSTLCLFR DEAKSLHDYS VRKFPVLSDF IVSFMLGINK
160 170 180 190 200
TKIPKESIYS DTVVDWCAGS FMLVRFSDFV RVNGFDQGYF MYCEDIDLCL
210 220 230 240 250
RLSLAGVRLH YVPAFHAIHY AHHDNRSFFS KAFRWHLKST FRYLARKRIL
260
SNRNFDRISS VFHP
Length:264
Mass (Da):31,061
Last modified:October 1, 1994 - v1
Checksum:iD75F681062AB5D40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19537 Genomic DNA. Translation: AAB49382.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.
U03041 Genomic DNA. Translation: AAC31637.1.
PIRiI76769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19537 Genomic DNA. Translation: AAB49382.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.
U03041 Genomic DNA. Translation: AAC31637.1.
PIRiI76769.

3D structure databases

ProteinModelPortaliP36667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP36667. 1 interaction.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Proteomic databases

PRIDEiP36667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EchoBASEiEB1929.
EcoGeneiEG11986. wbbL.

Phylogenomic databases

HOGENOMiHOG000224390.
InParanoidiP36667.
PhylomeDBiP36667.

Enzyme and pathway databases

UniPathwayiUPA00030.
BioCyciEcoCyc:EG11986-MONOMER.
BRENDAi2.4.1.289. 2026.

Miscellaneous databases

PROiP36667.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Escherichia coli K12 regains its O antigen."
    Liu D., Reeves P.R.
    Microbiology 140:49-57(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / WG1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Genetic analysis of the O-specific lipopolysaccharide biosynthesis region (rfb) of Escherichia coli K-12 W3110: identification of genes that confer group 6 specificity to Shigella flexneri serotypes Y and 4a."
    Yao Z., Valvano M.A.
    J. Bacteriol. 176:4133-4143(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster."
    Stevenson G., Neal B., Liu D., Hobbs M., Packer N.H., Batley M., Redmond J.W., Lindquist L., Reeves P.R.
    J. Bacteriol. 176:4144-4156(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RHAMNOSYLTRANSFERASE.

Entry informationi

Entry nameiWBBL_ECOLI
AccessioniPrimary (citable) accession number: P36667
Secondary accession number(s): O07999
, O08000, P76374, P94755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 17, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

PubMed:9097040, PubMed:9278503 and PubMed:16738553 sequences differ from that shown due to the presence of an IS5I insertion element between codons 148 and 149.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.