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Protein

Protein transport protein HofC homolog

Gene

hofC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG11798-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein HofC homolog
Gene namesi
Name:hofC
Synonyms:hopC, yacD
Ordered Locus Names:b0106, JW0102
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11798. hofC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002078451 – 400Protein transport protein HofC homologAdd BLAST400

Proteomic databases

PaxDbiP36646.
PRIDEiP36646.

Interactioni

Protein-protein interaction databases

BioGridi4261120. 155 interactors.
STRINGi316385.ECDH10B_0086.

Structurei

3D structure databases

ProteinModelPortaliP36646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP F family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7Q. Bacteria.
COG1459. LUCA.
HOGENOMiHOG000253740.
InParanoidiP36646.
KOiK02505.
PhylomeDBiP36646.

Family and domain databases

InterProiView protein in InterPro
IPR003004. GspF/PilC.
IPR018076. T2SS_F.
IPR001992. Type_2_secretion_system_CS.
PfamiView protein in Pfam
PF00482. T2SSF. 2 hits.
PRINTSiPR00812. BCTERIALGSPF.
PROSITEiView protein in PROSITE
PS00874. T2SP_F. 1 hit.

Sequencei

Sequence statusi: Complete.

P36646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKQLWRWH GITGDGNAQD GMLWAESRTL LLMALQQQMV TPLSLKRIAI
60 70 80 90 100
NSAQWRGDKS AEVIHQLATL LKAGLTLSEG LALLAEQHPS KQWQALLQSL
110 120 130 140 150
AHDLEQGIAF SNALLPWSEV FPPLYQAMIR TGELTGKLDE CCFELARQQK
160 170 180 190 200
AQRQLTDKVK SALRYPIIIL AMAIMVVVAM LHFVLPEFAA IYKTFNTPLP
210 220 230 240 250
ALTQGIMTLA DFSGEWSWLL VLFGFLLAIA NKLLMRRPTW LIVRQKLLLR
260 270 280 290 300
IPIMGSLMRG QKLTQIFTIL ALTQSAGITF LQGVESVRET MRCPYWVQLL
310 320 330 340 350
TQIQHDISNG QPIWLALKNT GEFSPLCLQL VRTGEASGSL DLMLDNLAHH
360 370 380 390 400
HRENTMALAD NLAALLEPAL LIITGGIIGT LVVAMYLPIF HLGDAMSGMG
Length:400
Mass (Da):44,450
Last modified:November 1, 1997 - v3
Checksum:i9D37332B87AE07D5
GO

Sequence cautioni

The sequence X07917 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 39MASKQ…LQQQM → MAVSNSGAGMAYAQVVLTT in AAC36925 (PubMed:7959070).CuratedAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28105 Genomic DNA. Translation: AAC36925.1.
U00096 Genomic DNA. Translation: AAC73217.1.
AP009048 Genomic DNA. Translation: BAB96674.2.
X07917 Genomic DNA. No translation available.
PIRiB64733.
RefSeqiNP_414648.1. NC_000913.3.
WP_000157266.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73217; AAC73217; b0106.
BAB96674; BAB96674; BAB96674.
GeneIDi945806.
KEGGiecj:JW0102.
eco:b0106.
PATRICifig|1411691.4.peg.2176.

Similar proteinsi

Entry informationi

Entry nameiHOFC_ECOLI
AccessioniPrimary (citable) accession number: P36646
Secondary accession number(s): P75648, Q47020, Q47021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families