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Protein

Protein transport protein HofC homolog

Gene

hofC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • plasmid maintenance Source: EcoCyc
  • protein secretion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11798-MONOMER.
ECOL316407:JW0102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein HofC homolog
Gene namesi
Name:hofC
Synonyms:hopC, yacD
Ordered Locus Names:b0106, JW0102
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11798. hofC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Protein transport protein HofC homologPRO_0000207845Add
BLAST

Proteomic databases

PaxDbiP36646.
PRIDEiP36646.

Interactioni

Protein-protein interaction databases

BioGridi4261120. 155 interactions.
STRINGi511145.b0106.

Structurei

3D structure databases

ProteinModelPortaliP36646.
SMRiP36646. Positions 66-139, 270-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP F family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7Q. Bacteria.
COG1459. LUCA.
HOGENOMiHOG000253740.
InParanoidiP36646.
KOiK02505.
OMAiMELQMNK.
PhylomeDBiP36646.

Family and domain databases

InterProiIPR003004. GspF/PilC.
IPR018076. T2SS_F.
IPR001992. Type_2_secretion_system_CS.
[Graphical view]
PfamiPF00482. T2SSF. 2 hits.
[Graphical view]
PRINTSiPR00812. BCTERIALGSPF.
PROSITEiPS00874. T2SP_F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKQLWRWH GITGDGNAQD GMLWAESRTL LLMALQQQMV TPLSLKRIAI
60 70 80 90 100
NSAQWRGDKS AEVIHQLATL LKAGLTLSEG LALLAEQHPS KQWQALLQSL
110 120 130 140 150
AHDLEQGIAF SNALLPWSEV FPPLYQAMIR TGELTGKLDE CCFELARQQK
160 170 180 190 200
AQRQLTDKVK SALRYPIIIL AMAIMVVVAM LHFVLPEFAA IYKTFNTPLP
210 220 230 240 250
ALTQGIMTLA DFSGEWSWLL VLFGFLLAIA NKLLMRRPTW LIVRQKLLLR
260 270 280 290 300
IPIMGSLMRG QKLTQIFTIL ALTQSAGITF LQGVESVRET MRCPYWVQLL
310 320 330 340 350
TQIQHDISNG QPIWLALKNT GEFSPLCLQL VRTGEASGSL DLMLDNLAHH
360 370 380 390 400
HRENTMALAD NLAALLEPAL LIITGGIIGT LVVAMYLPIF HLGDAMSGMG
Length:400
Mass (Da):44,450
Last modified:November 1, 1997 - v3
Checksum:i9D37332B87AE07D5
GO

Sequence cautioni

The sequence X07917 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 3939MASKQ…LQQQM → MAVSNSGAGMAYAQVVLTT in AAC36925 (PubMed:7959070).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28105 Genomic DNA. Translation: AAC36925.1.
U00096 Genomic DNA. Translation: AAC73217.1.
AP009048 Genomic DNA. Translation: BAB96674.2.
X07917 Genomic DNA. No translation available.
PIRiB64733.
RefSeqiNP_414648.1. NC_000913.3.
WP_000157266.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73217; AAC73217; b0106.
BAB96674; BAB96674; BAB96674.
GeneIDi945806.
KEGGiecj:JW0102.
eco:b0106.
PATRICi32115313. VBIEscCol129921_0108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28105 Genomic DNA. Translation: AAC36925.1.
U00096 Genomic DNA. Translation: AAC73217.1.
AP009048 Genomic DNA. Translation: BAB96674.2.
X07917 Genomic DNA. No translation available.
PIRiB64733.
RefSeqiNP_414648.1. NC_000913.3.
WP_000157266.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36646.
SMRiP36646. Positions 66-139, 270-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261120. 155 interactions.
STRINGi511145.b0106.

Proteomic databases

PaxDbiP36646.
PRIDEiP36646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73217; AAC73217; b0106.
BAB96674; BAB96674; BAB96674.
GeneIDi945806.
KEGGiecj:JW0102.
eco:b0106.
PATRICi32115313. VBIEscCol129921_0108.

Organism-specific databases

EchoBASEiEB1746.
EcoGeneiEG11798. hofC.

Phylogenomic databases

eggNOGiENOG4105D7Q. Bacteria.
COG1459. LUCA.
HOGENOMiHOG000253740.
InParanoidiP36646.
KOiK02505.
OMAiMELQMNK.
PhylomeDBiP36646.

Enzyme and pathway databases

BioCyciEcoCyc:EG11798-MONOMER.
ECOL316407:JW0102-MONOMER.

Miscellaneous databases

PROiP36646.

Family and domain databases

InterProiIPR003004. GspF/PilC.
IPR018076. T2SS_F.
IPR001992. Type_2_secretion_system_CS.
[Graphical view]
PfamiPF00482. T2SSF. 2 hits.
[Graphical view]
PRINTSiPR00812. BCTERIALGSPF.
PROSITEiPS00874. T2SP_F. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOFC_ECOLI
AccessioniPrimary (citable) accession number: P36646
Secondary accession number(s): P75648, Q47020, Q47021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.