P36645 (HOFB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein transport protein HofB homolog

Gene names

Name:	hofB
Synonyms:	hopB
Ordered Locus Names:	b0107, JW0103

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the GSP E family.

Ontologies

Keywords
Biological process	Transport
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	plasmid maintenance Inferred from mutant phenotype PubMed 3053654. Source: EcoCyc transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Protein transport protein HofB homolog		PRO_0000207305
Regions
	Nucleotide binding	222 – 229	8	ATP Potential
Experimental info
	Sequence conflict	8 – 9	2	AL → EM in AAC36924. Ref.1
	Sequence conflict	35	1	H → L in AAC36924. Ref.1
	Sequence conflict	457 – 461	5	MPHGE → DAAWQ in AAC36924. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P36645 [UniParc]. Last modified November 1, 1997. Version 3. Checksum: 3E3A72AB05760255	FASTA	461	50,615
	10 20 30 40 50 60 MNIPQLTALC LRYHGVLLDA SEEVVHVAVV DAPSHELLDA LHFATTKRIE ITCWTRQQME 70 80 90 100 110 120 GHASRTQQTL PVAVQEKHQP KAELLTRTLQ SALEQRASDI HIEPADNAYR IRLRIDGVLH 130 140 150 160 170 180 PLPDVSPDAG VALTARLKVL GNLDIAEHRL PQDGQFTVEL AGNAVSFRIA TLPCRGGEKV 190 200 210 220 230 240 VLRLLQQVGQ ALDVNTLGMQ PLQLADFAHA LQQPQGLVLV TGPTGSGKTV TLYSALQKLN 250 260 270 280 290 300 TADINICSVE DPVEIPIAGL NQTQIHPRAG LTFQGVLRAL LRQDPDVIMI GEIRDGETAE 310 320 330 340 350 360 IAIKAAQTGH LVLSTLHTNS TCETLVRLQQ MGVARWMLSS ALTLVIAQRL VRKLCPHCRR 370 380 390 400 410 420 QQGEPIHIPD NVWPSPLPHW QAPGCVHCYH GFYGRTALFE VLPITPVIRQ LISANTDVES 430 440 450 460 LETHARQAGM RTLFENGCLA VEQGLTTFEE LIRVLGMPHG E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria." Whitchurch C.B., Mattick J.S. Gene 150:9-15(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region." Fujita N., Mori H., Yura T., Ishihama A. Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	Bhatia R.S. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-283. Strain: K12.
[6]	Rudd K.R. Unpublished observations (JAN-1994) Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L28105 Genomic DNA. Translation: AAC36924.1. U00096 Genomic DNA. Translation: AAC73218.1. AP009048 Genomic DNA. Translation: BAB96676.2. L20834 Genomic DNA. No translation available.
PIR	C64733.
RefSeq	NP_414649.1. NC_000913.2. YP_488410.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P36645.
SMR	P36645. Positions 80-453.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9919N.
IntAct	P36645. 5 interactions.
STRING	511145.b0107.
Proteomic databases
PaxDb	P36645.
PRIDE	P36645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73218; AAC73218; b0107. BAB96676; BAB96676; BAB96676.
GeneID	12932690. 947481.
KEGG	ecj:Y75_p0104. eco:b0107.
PATRIC	32115315. VBIEscCol129921_0109.
Organism-specific databases
EchoBASE	EB2030.
EcoGene	EG12106. hofB.
Phylogenomic databases
eggNOG	COG2804.
HOGENOM	HOG000008427.
KO	K02504.
OMA	KRIDIEC.
ProtClustDB	PRK10436.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12106-MONOMER. ECOL316407:JW0103-MONOMER.
Gene expression databases
Genevestigator	P36645.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR007831. GSPII_E_N. IPR001482. T2SS_protein-E. [Graphical view]
Pfam	PF00437. T2SE. 1 hit. PF05157. T2SE_Nter. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00662. T2SP_E. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOFB_ECOLI

Accession

Primary (citable) accession number: P36645
Secondary accession number(s): P75649, Q47022

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program