Magnesium-transporting ATPase, P-type 1

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P36640 (ATMA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Magnesium-transporting ATPase, P-type 1
EC=3.6.3.2

Alternative name(s):
Mg(2+) transport ATPase, P-type 1

Gene names

Name:	mgtA
Ordered Locus Names:	STM4456

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	902 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates magnesium influx to the cytosol.
Catalytic activity	ATP + H₂O + Mg²⁺(Out) = ADP + phosphate + Mg²⁺(In).
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Induction	Induced by low levels of proline and by osmotic shock. The leader of mgtA mRNA functions as a riboswitch, favoring transcription under low Mg²⁺ conditions. Under limiting proline levels the MgtL peptide encoded within the mgtA leader cannot be translated, thereby favoring the transcription of the mgtA ORF. Induction by osmotic shock also depends on translational regulation by MgtL Probable. Induced by low extracellular levels of Mg²⁺. Ref.1
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium-importing ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 902

902

Magnesium-transporting ATPase, P-type 1

PRO_0000046184

Regions

Topological domain

1 – 98

Cytoplasmic Potential

Transmembrane

99 – 119

Helical; Name=1; Potential

Topological domain

120

Extracellular Potential

Transmembrane

121 – 141

Helical; Name=2; Potential

Topological domain

142 – 291

150

Cytoplasmic Potential

Transmembrane

292 – 312

Helical; Name=3; Potential

Topological domain

313 – 321

Extracellular Potential

Transmembrane

322 – 339

Helical; Name=4; Potential

Topological domain

340 – 699

360

Cytoplasmic Potential

Transmembrane

700 – 719

Helical; Name=5; Potential

Topological domain

720 – 728

Extracellular Potential

Transmembrane

729 – 748

Helical; Name=6; Potential

Topological domain

749 – 770

Cytoplasmic Potential

Transmembrane

771 – 794

Helical; Name=7; Potential

Topological domain

795 – 803

Extracellular Potential

Transmembrane

804 – 822

Helical; Name=8; Potential

Topological domain

823 – 835

Cytoplasmic Potential

Transmembrane

836 – 855

Helical; Name=9; Potential

Topological domain

856 – 870

Extracellular Potential

Transmembrane

871 – 890

Helical; Name=10; Potential

Topological domain

891 – 902

Cytoplasmic Potential

Sites

Active site

377

4-aspartylphosphate intermediate By similarity

Metal binding

335

Magnesium Potential

Metal binding

645

Magnesium By similarity

Metal binding

649

Magnesium By similarity

Metal binding

713

Magnesium Potential

Metal binding

738

Magnesium Potential

Metal binding

742

Magnesium Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P36640 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 3D2712E9A074C957
Show »

FASTA

902

99,783

        10         20         30         40         50         60 
MLKIITRQLF ARLNRHLPYR LVHRDPLPGA QTAVNATIPP SLSERCLKVA AMEQETLWRV 

        70         80         90        100        110        120 
FDTHPEGLNA AEVTRAREKH GENRLPAQKP SPWWVHLWVC YRNPFNILLT ILGGISYATE 

       130        140        150        160        170        180 
DLFAAGVIAL MVGISTLLNF VQEARSTKAA DALKAMVSNT ATVLRVINEN GENAWLELPI 

       190        200        210        220        230        240 
DQLVPGDIIK LAAGDMIPAD LRIIQARDLF VAQASLTGES LPVEKVAATR EPRQNNPLEC 

       250        260        270        280        290        300 
DTLCFMGTNV VSGTAQAVVM ATGAGTWFGQ LAGRVSEQDN EQNAFQKGIS RVSMLLIRFM 

       310        320        330        340        350        360 
LVMAPVVLII NGYTKGDWWE AALFALSVAV GLTPEMLPMI VTSTLARGAV KLSKQKVIVK 

       370        380        390        400        410        420 
HLDAIQNFGA MDILCTDKTG TLTQDKIVLE NHTDISGKPS EHVLHCAWLN SHYQTGLKNL 

       430        440        450        460        470        480 
LDTAVLEGVD ETAARQLSGR WQKIDEIPFD FERRRMSVVV AEDSNVHQLV CKGALQEILN 

       490        500        510        520        530        540 
VCTQVRHNGD IVPLDDNMLR RVKRVTDTLN RQGLRVVAVA TKYLPAREGD YQRIDESDLI 

       550        560        570        580        590        600 
LEGYIAFLDP PKETTAPALK ALKASGITVK ILTGDSELVA AKVCHEVGLD AGDVIIGSDI 

       610        620        630        640        650        660 
EGLSDDALAA LAARTTLFAR LTPMHKERIV TLLKREGHVV GFMGDGINDA PALRAADIGI 

       670        680        690        700        710        720 
SVDGAVDIAR EAADIILLEK SLMVLEEGVI EGRRTFSNML KYIKMTASSN FGNVFSVLVA 

       730        740        750        760        770        780 
SAFLPFLPML PLHLLIQNLL YDVSQVAIPF DNVDEEQIQK PQRWNPADLG RFMVFFGPIS 

       790        800        810        820        830        840 
SIFDILTFCL MWWVFHANTP ETQTLFQSGW FVVGLLSQTL IVHMIRTRRL PFIQSRAAWP 

       850        860        870        880        890        900 
LMAMTLLVMV VGVSLPFSPL ASYLQLQALP LSYFPWLIAI LVGYMTLTQL VKGFYSRRYG 


WQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Magnesium transport in Salmonella typhimurium: mgtA encodes a P-type ATPase and is regulated by Mg2+ in a manner similar to that of the mgtB P-type ATPase." Tao T., Snavely M.D., Farr S.G., Maguire M.E. J. Bacteriol. 177:2654-2662(1995) [PubMed: 7751273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07843 Genomic DNA. Translation: AAA68988.1. AE006468 Genomic DNA. Translation: AAL23275.1.
PIR	B57147.
RefSeq	NP_463316.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P36640.
ModBase	Search...
Protein family/group databases
TCDB	3.A.3.4.1. P-type ATPase (P-ATPase) superfamily.
Proteomic databases
PRIDE	P36640.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1255982.
GenomeReviews	Gene locus STM4456 in contig AE006468_GR.
KEGG	stm:STM4456.
NMPDR	fig\|99287.1.peg.4285.
PATRIC	32387851. VBISalEnt20916_4689.
Phylogenomic databases
HOGENOM	HBG456486.
OMA	HIFAKLS.
ProtClustDB	PRK10517.
Enzyme and pathway databases
BioCyc	STYP99287:STM4456-MONOMER.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR006415. ATPase_P-typ_Mg-translocating. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
KO	K01531.
PANTHER	PTHR24093:SF62. PTHR24093:SF62. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR01836. MGATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01524. ATPase-IIIB_Mg. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATMA_SALTY

Accession

Primary (citable) accession number: P36640

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents