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Protein

G2/mitotic-specific cyclin cig2

Gene

cig2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.7 Publications

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • conjugation Source: UniProtKB-KW
  • negative regulation of conjugation with cellular fusion Source: PomBase
  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: PomBase
  • positive regulation of G1/S transition of mitotic cell cycle Source: PomBase
  • protein phosphorylation Source: GOC
  • regulation of meiotic cell cycle Source: PomBase
  • signal transduction involved in G1 cell size control checkpoint Source: PomBase
  • traversing start control point of mitotic cell cycle Source: PomBase

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Conjugation, Mitosis

Enzyme and pathway databases

ReactomeiR-SPO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-SPO-2500257 Resolution of Sister Chromatid Cohesion
R-SPO-4419969 Depolymerisation of the Nuclear Lamina
R-SPO-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SPO-69478 G2/M DNA replication checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin cig2
Gene namesi
Name:cig2
Synonyms:cyc17
ORF Names:SPAPB2B4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPAPB2B4.03
PomBaseiSPAPB2B4.03 cig2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51R → A: Improves protein stability; when associated with A-54. 1 Publication1
Mutagenesisi54L → A: Improves protein stability; when associated with A-51. 1 Publication1
Mutagenesisi169R → A: Prevents binding to cdc2 and improves protein stability; when associated with A-170 and A-171. 1 Publication1
Mutagenesisi170E → A: Prevents binding to cdc2 and improves protein stability; when associated with A-169 and A-171. 1 Publication1
Mutagenesisi171I → A: Prevents binding to cdc2 and improves protein stability; when associated with A-169 and A-170. 1 Publication1
Mutagenesisi268S → N: No effect on protein stability; when associated with A-329. 1 Publication1
Mutagenesisi329T → A: No effect on protein stability; when associated with N-268. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804011 – 411G2/mitotic-specific cyclin cig2Add BLAST411

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36630
PaxDbiP36630
PRIDEiP36630

PTM databases

iPTMnetiP36630

Expressioni

Inductioni

Highly induced upon nitrogen starvation and during conjugation.1 Publication

Interactioni

Subunit structurei

Associates with cdc2, res2 and rum1. Interacts with pop1 only when phosphorylated.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi279901, 38 interactors
IntActiP36630, 5 interactors
STRINGi4896.SPAPB2B4.03.1

Structurei

3D structure databases

ProteinModelPortaliP36630
SMRiP36630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 265Cyclin N-terminalAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 273Interaction with pop1Add BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 60Destruction box10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi394 – 397Poly-Asp4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000167672
InParanoidiP36630
KOiK02220
OrthoDBiEOG092C2S0G
PhylomeDBiP36630

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P36630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALYSISKPV GSKINKHSYQ DENTLVGKQA LSKGTEKTKL STNFEINLPR
60 70 80 90 100
RTVLSDVSNV GKNNADEKDT KKAKRSFDES NLSTNEEADK PVESKFVKKL
110 120 130 140 150
KVYSKNADPS VETLQKDRVS NVDDHLSSNP LMAEEYAPEI FEYIRKLDLK
160 170 180 190 200
CLPNPKYMDQ QKELTWKMRE ILNEWLVEIH SNFCLMPETL YLAVNIIDRF
210 220 230 240 250
LSRRSCSLSK FQLTGITALL IASKYEEVMC PSIQNFVYMT DGAFTVEDVC
260 270 280 290 300
VAERYMLNVL NFDLSYPSPL NFLRKISQAE GYDAQTRTLG KYLTEIYLFD
310 320 330 340 350
HDLLRYPMSK IAAAAMYLSR RLLRRGPWTP KLVESSGGYE EHELKEIAYI
360 370 380 390 400
MLHYHNKPLE HKAFFQKYSS KRFLKASIFV HQLVRQRYSV NRTDDDDLQS
410
EPSSSLTNDG H
Length:411
Mass (Da):47,477
Last modified:February 1, 1995 - v2
Checksum:i6F255D2E26C6F8B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 49MALYS…EINLP → MKTHLLANKLYQKGLRRQNY LQICKLICHA in CAA49640 (PubMed:8455610).CuratedAdd BLAST49
Sequence conflicti119 – 124VSNVDD → ALMLMN in CAA49640 (PubMed:8455610).Curated6
Sequence conflicti315Missing in CAA49640 (PubMed:8455610).Curated1
Sequence conflicti330P → A in CAA49640 (PubMed:8455610).Curated1
Sequence conflicti411H → QRTLL in CAA49640 (PubMed:8455610).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70046 mRNA Translation: CAA49640.1
D28751 mRNA Translation: BAA05943.1
S67490 mRNA Translation: AAB29297.2 Sequence problems.
CU329670 Genomic DNA Translation: CAC21469.1
PIRiA48100
S44344
T52009
RefSeqiNP_593889.1, NM_001019319.2

Genome annotation databases

EnsemblFungiiSPAPB2B4.03.1; SPAPB2B4.03.1:pep; SPAPB2B4.03
GeneIDi2543481
KEGGispo:SPAPB2B4.03

Similar proteinsi

Entry informationi

Entry nameiCG22_SCHPO
AccessioniPrimary (citable) accession number: P36630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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