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P36626 (REC8_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Meiotic recombination protein rec8
Alternative name(s):
Cohesin rec8
Gene names
Name:rec8
ORF Names:SPBC29A10.14
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Ref.2 Ref.6

Subunit structure

Interacts with moa1. Ref.5

Subcellular location

Nucleus Ref.1 Ref.7.

Developmental stage

Abundant at 3 hours after induction of meiosis but undetectable before induction or at 4 hours and later.

Post-translational modification

Phosphorylated during prophase until after meiosis I. Ref.1 Ref.2

Sequence similarities

Belongs to the rad21 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

moa1Q9UTI42EBI-1564281,EBI-1564258

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Meiotic recombination protein rec8
PRO_0000097880

Experimental info

Sequence conflict531 – 56131SLATK…STDAI → CKYHNQTTN in AAB04034. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P36626 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: E6B9B3A02143D50A

FASTA56164,011
        10         20         30         40         50         60 
MFYNQDVLTK EKGGMGVIWL AATLGSKHSL RKLHKKDIMS VDIDEACDFV AFSPEPLALR 

        70         80         90        100        110        120 
LSSNLMIGVT RVWAHQYSFF HSQVSTLHLR VRKELDHFTS KPFKNIDIQN EQTNPKQLLL 

       130        140        150        160        170        180 
AEDPAFIPEV SLYDAFNLPS VDLHVDMSSF TQPKENPNIS VLETLPDSTS YLINTSQNYS 

       190        200        210        220        230        240 
LRNNVSSFVY EDSRAFSTEE PLDFEFDENG DIQELTKGTI NSDPSLQAAS QHSNLGSVQR 

       250        260        270        280        290        300 
EYNSEEQESR IHMFEIDEDV LPLPVPLQSV MDSEHNENEP RALKRRKVQK LLEPDENIEL 

       310        320        330        340        350        360 
STRTLSQWRK NYVERMIALE ATKYVRRRGA SSAKKKELNK FFDWESFHPL LKPWIEKLKP 

       370        380        390        400        410        420 
SNNTPSEIDD VLRNIDTSEV EVGRDVQGEL GLNIPWNTSS RSNSAINSKS HSQTGSEHST 

       430        440        450        460        470        480 
PLLDTKYRKR LPHSPSMPSR VEFLPALESS QFHETLNSEL SLQLSDDFVL YKNTQEENAH 

       490        500        510        520        530        540 
LMLSMEKECA NFYEYAKTAI YENNGRITFS SLLPNDLKRP VVAQAFSHLL SLATKSAFLV 

       550        560 
KQDKPYSEIS VSLNLKSTDA I 

« Hide

References

« Hide 'large scale' references
[1]"Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans."
Parisi S., McKay M.J., Molnar M., Thompson M.A., van der Spek P.J., van Drunen-Schoenmaker E., Kanaar R., Lehmann E., Hoeijmakers J.H.J., Kohli J.
Mol. Cell. Biol. 19:3515-3528(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, PHOSPHORYLATION.
[2]"Cohesin Rec8 is required for reductional chromosome segregation at meiosis."
Watanabe Y., Nurse P.
Nature 400:461-464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[4]"Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe."
Lin Y., Larson K.L., Dorer R., Smith G.R.
Genetics 132:75-85(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-561.
[5]"The kinetochore protein moa1 enables cohesion-mediated monopolar attachment at meiosis I."
Yokobayashi S., Watanabe Y.
Cell 123:803-817(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MOA1.
[6]"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN MEIOSIS.
[7]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ223299 Genomic DNA. Translation: CAA11240.1.
AB018077 mRNA. Translation: BAA33496.1.
CU329671 Genomic DNA. Translation: CAA22442.1.
M85298 Genomic DNA. Translation: AAB04034.1.
PIRT43428.
RefSeqNP_596059.1. NM_001021970.2.

3D structure databases

ProteinModelPortalP36626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276986. 14 interactions.
IntActP36626. 1 interaction.
MINTMINT-4689209.
STRING4896.SPBC29A10.14-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC29A10.14.1; SPBC29A10.14.1:pep; SPBC29A10.14.
GeneID2540458.
KEGGspo:SPBC29A10.14.

Organism-specific databases

PomBaseSPBC29A10.14.

Phylogenomic databases

eggNOGNOG42761.
KOK12780.
OrthoDBEOG7KSXM4.
PhylomeDBP36626.

Family and domain databases

Gene3D1.10.10.580. 1 hit.
InterProIPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
[Graphical view]
PfamPF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801585.

Entry information

Entry nameREC8_SCHPO
AccessionPrimary (citable) accession number: P36626
Secondary accession number(s): O60051
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names