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Protein

Meiotic recombination protein rec8

Gene

rec8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.2 Publications

GO - Molecular functioni

GO - Biological processi

  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
  • double-strand break repair Source: GO_Central
  • meiotic sister chromatid cohesion, centromeric Source: PomBase
  • meiotic sister chromatid cohesion involved in meiosis I Source: PomBase
  • synapsis Source: PomBase

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein rec8
Alternative name(s):
Cohesin rec8
Gene namesi
Name:rec8
ORF Names:SPBC29A10.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC29A10.14
PomBaseiSPBC29A10.14 rec8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000978801 – 561Meiotic recombination protein rec8Add BLAST561

Post-translational modificationi

Phosphorylated during prophase until after meiosis I.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP36626
PRIDEiP36626

Expressioni

Developmental stagei

Abundant at 3 hours after induction of meiosis but undetectable before induction or at 4 hours and later.

Interactioni

Subunit structurei

Interacts with moa1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
moa1Q9UTI42EBI-1564281,EBI-1564258

Protein-protein interaction databases

BioGridi276986, 18 interactors
IntActiP36626, 1 interactor
STRINGi4896.SPBC29A10.14.1

Structurei

3D structure databases

ProteinModelPortaliP36626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rad21 family.Curated

Phylogenomic databases

InParanoidiP36626
KOiK12780
OrthoDBiEOG092C32W1
PhylomeDBiP36626

Family and domain databases

InterProiView protein in InterPro
IPR006909 Rad21/Rec8_C_eu
IPR006910 Rad21_Rec8_N
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF04824 Rad21_Rec8, 1 hit
PF04825 Rad21_Rec8_N, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

P36626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYNQDVLTK EKGGMGVIWL AATLGSKHSL RKLHKKDIMS VDIDEACDFV
60 70 80 90 100
AFSPEPLALR LSSNLMIGVT RVWAHQYSFF HSQVSTLHLR VRKELDHFTS
110 120 130 140 150
KPFKNIDIQN EQTNPKQLLL AEDPAFIPEV SLYDAFNLPS VDLHVDMSSF
160 170 180 190 200
TQPKENPNIS VLETLPDSTS YLINTSQNYS LRNNVSSFVY EDSRAFSTEE
210 220 230 240 250
PLDFEFDENG DIQELTKGTI NSDPSLQAAS QHSNLGSVQR EYNSEEQESR
260 270 280 290 300
IHMFEIDEDV LPLPVPLQSV MDSEHNENEP RALKRRKVQK LLEPDENIEL
310 320 330 340 350
STRTLSQWRK NYVERMIALE ATKYVRRRGA SSAKKKELNK FFDWESFHPL
360 370 380 390 400
LKPWIEKLKP SNNTPSEIDD VLRNIDTSEV EVGRDVQGEL GLNIPWNTSS
410 420 430 440 450
RSNSAINSKS HSQTGSEHST PLLDTKYRKR LPHSPSMPSR VEFLPALESS
460 470 480 490 500
QFHETLNSEL SLQLSDDFVL YKNTQEENAH LMLSMEKECA NFYEYAKTAI
510 520 530 540 550
YENNGRITFS SLLPNDLKRP VVAQAFSHLL SLATKSAFLV KQDKPYSEIS
560
VSLNLKSTDA I
Length:561
Mass (Da):64,011
Last modified:January 11, 2001 - v2
Checksum:iE6B9B3A02143D50A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531 – 561SLATK…STDAI → CKYHNQTTN in AAB04034 (PubMed:1339382).CuratedAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223299 Genomic DNA Translation: CAA11240.1
AB018077 mRNA Translation: BAA33496.1
CU329671 Genomic DNA Translation: CAA22442.1
M85298 Genomic DNA Translation: AAB04034.1
PIRiT43428
RefSeqiNP_596059.1, NM_001021970.2

Genome annotation databases

EnsemblFungiiSPBC29A10.14.1; SPBC29A10.14.1:pep; SPBC29A10.14
GeneIDi2540458
KEGGispo:SPBC29A10.14

Similar proteinsi

Entry informationi

Entry nameiREC8_SCHPO
AccessioniPrimary (citable) accession number: P36626
Secondary accession number(s): O60051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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