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P36626

- REC8_SCHPO

UniProt

P36626 - REC8_SCHPO

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Protein
Meiotic recombination protein rec8
Gene
rec8, SPBC29A10.14
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
  2. homologous chromosome segregation Source: PomBase
  3. linear element assembly Source: PomBase
  4. meiotic DNA double-strand break formation Source: PomBase
  5. meiotic sister chromatid segregation Source: PomBase
  6. reciprocal meiotic recombination Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein rec8
Alternative name(s):
Cohesin rec8
Gene namesi
Name:rec8
ORF Names:SPBC29A10.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC29A10.14.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cohesin complex Source: PomBase
  2. condensed chromosome inner kinetochore Source: PomBase
  3. meiotic cohesin complex Source: PomBase
  4. nuclear chromosome Source: InterPro
  5. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Meiotic recombination protein rec8
PRO_0000097880Add
BLAST

Post-translational modificationi

Phosphorylated during prophase until after meiosis I.2 Publications

Keywords - PTMi

Phosphoprotein

Expressioni

Developmental stagei

Abundant at 3 hours after induction of meiosis but undetectable before induction or at 4 hours and later.

Interactioni

Subunit structurei

Interacts with moa1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
moa1Q9UTI42EBI-1564281,EBI-1564258

Protein-protein interaction databases

BioGridi276986. 14 interactions.
IntActiP36626. 1 interaction.
MINTiMINT-4689209.
STRINGi4896.SPBC29A10.14-1.

Structurei

3D structure databases

ProteinModelPortaliP36626.

Family & Domainsi

Sequence similaritiesi

Belongs to the rad21 family.

Phylogenomic databases

eggNOGiNOG42761.
KOiK12780.
OrthoDBiEOG7KSXM4.
PhylomeDBiP36626.

Family and domain databases

Gene3Di1.10.10.580. 1 hit.
InterProiIPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
[Graphical view]
PfamiPF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36626-1 [UniParc]FASTAAdd to Basket

« Hide

MFYNQDVLTK EKGGMGVIWL AATLGSKHSL RKLHKKDIMS VDIDEACDFV    50
AFSPEPLALR LSSNLMIGVT RVWAHQYSFF HSQVSTLHLR VRKELDHFTS 100
KPFKNIDIQN EQTNPKQLLL AEDPAFIPEV SLYDAFNLPS VDLHVDMSSF 150
TQPKENPNIS VLETLPDSTS YLINTSQNYS LRNNVSSFVY EDSRAFSTEE 200
PLDFEFDENG DIQELTKGTI NSDPSLQAAS QHSNLGSVQR EYNSEEQESR 250
IHMFEIDEDV LPLPVPLQSV MDSEHNENEP RALKRRKVQK LLEPDENIEL 300
STRTLSQWRK NYVERMIALE ATKYVRRRGA SSAKKKELNK FFDWESFHPL 350
LKPWIEKLKP SNNTPSEIDD VLRNIDTSEV EVGRDVQGEL GLNIPWNTSS 400
RSNSAINSKS HSQTGSEHST PLLDTKYRKR LPHSPSMPSR VEFLPALESS 450
QFHETLNSEL SLQLSDDFVL YKNTQEENAH LMLSMEKECA NFYEYAKTAI 500
YENNGRITFS SLLPNDLKRP VVAQAFSHLL SLATKSAFLV KQDKPYSEIS 550
VSLNLKSTDA I 561
Length:561
Mass (Da):64,011
Last modified:January 11, 2001 - v2
Checksum:iE6B9B3A02143D50A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti531 – 56131SLATK…STDAI → CKYHNQTTN in AAB04034. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223299 Genomic DNA. Translation: CAA11240.1.
AB018077 mRNA. Translation: BAA33496.1.
CU329671 Genomic DNA. Translation: CAA22442.1.
M85298 Genomic DNA. Translation: AAB04034.1.
PIRiT43428.
RefSeqiNP_596059.1. NM_001021970.2.

Genome annotation databases

EnsemblFungiiSPBC29A10.14.1; SPBC29A10.14.1:pep; SPBC29A10.14.
GeneIDi2540458.
KEGGispo:SPBC29A10.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223299 Genomic DNA. Translation: CAA11240.1 .
AB018077 mRNA. Translation: BAA33496.1 .
CU329671 Genomic DNA. Translation: CAA22442.1 .
M85298 Genomic DNA. Translation: AAB04034.1 .
PIRi T43428.
RefSeqi NP_596059.1. NM_001021970.2.

3D structure databases

ProteinModelPortali P36626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276986. 14 interactions.
IntActi P36626. 1 interaction.
MINTi MINT-4689209.
STRINGi 4896.SPBC29A10.14-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC29A10.14.1 ; SPBC29A10.14.1:pep ; SPBC29A10.14 .
GeneIDi 2540458.
KEGGi spo:SPBC29A10.14.

Organism-specific databases

PomBasei SPBC29A10.14.

Phylogenomic databases

eggNOGi NOG42761.
KOi K12780.
OrthoDBi EOG7KSXM4.
PhylomeDBi P36626.

Miscellaneous databases

NextBioi 20801585.

Family and domain databases

Gene3Di 1.10.10.580. 1 hit.
InterProi IPR023093. Rad21/Rec8_C.
IPR006909. Rad21/Rec8_C_eu.
IPR006910. Rad21_Rec8_N.
[Graphical view ]
Pfami PF04824. Rad21_Rec8. 1 hit.
PF04825. Rad21_Rec8_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans."
    Parisi S., McKay M.J., Molnar M., Thompson M.A., van der Spek P.J., van Drunen-Schoenmaker E., Kanaar R., Lehmann E., Hoeijmakers J.H.J., Kohli J.
    Mol. Cell. Biol. 19:3515-3528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, PHOSPHORYLATION.
  2. "Cohesin Rec8 is required for reductional chromosome segregation at meiosis."
    Watanabe Y., Nurse P.
    Nature 400:461-464(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. "Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe."
    Lin Y., Larson K.L., Dorer R., Smith G.R.
    Genetics 132:75-85(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-561.
  5. "The kinetochore protein moa1 enables cohesion-mediated monopolar attachment at meiosis I."
    Yokobayashi S., Watanabe Y.
    Cell 123:803-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MOA1.
  6. "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
    Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
    Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEIOSIS.
  7. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiREC8_SCHPO
AccessioniPrimary (citable) accession number: P36626
Secondary accession number(s): O60051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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