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P36626

- REC8_SCHPO

UniProt

P36626 - REC8_SCHPO

Protein

Meiotic recombination protein rec8

Gene

rec8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
    2. homologous chromosome segregation Source: PomBase
    3. linear element assembly Source: PomBase
    4. meiotic DNA double-strand break formation Source: PomBase
    5. meiotic sister chromatid segregation Source: PomBase
    6. reciprocal meiotic recombination Source: PomBase

    Keywords - Biological processi

    Meiosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Meiotic recombination protein rec8
    Alternative name(s):
    Cohesin rec8
    Gene namesi
    Name:rec8
    ORF Names:SPBC29A10.14
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC29A10.14.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. condensed nuclear chromosome inner kinetochore Source: PomBase
    2. nuclear cohesin complex Source: PomBase
    3. nuclear meiotic cohesin complex Source: PomBase
    4. nucleus Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Meiotic recombination protein rec8PRO_0000097880Add
    BLAST

    Post-translational modificationi

    Phosphorylated during prophase until after meiosis I.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Developmental stagei

    Abundant at 3 hours after induction of meiosis but undetectable before induction or at 4 hours and later.

    Interactioni

    Subunit structurei

    Interacts with moa1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    moa1Q9UTI42EBI-1564281,EBI-1564258

    Protein-protein interaction databases

    BioGridi276986. 14 interactions.
    IntActiP36626. 1 interaction.
    MINTiMINT-4689209.
    STRINGi4896.SPBC29A10.14-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP36626.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rad21 family.Curated

    Phylogenomic databases

    eggNOGiNOG42761.
    KOiK12780.
    OrthoDBiEOG7KSXM4.
    PhylomeDBiP36626.

    Family and domain databases

    Gene3Di1.10.10.580. 1 hit.
    InterProiIPR023093. Rad21/Rec8_C.
    IPR006909. Rad21/Rec8_C_eu.
    IPR006910. Rad21_Rec8_N.
    [Graphical view]
    PfamiPF04824. Rad21_Rec8. 1 hit.
    PF04825. Rad21_Rec8_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYNQDVLTK EKGGMGVIWL AATLGSKHSL RKLHKKDIMS VDIDEACDFV    50
    AFSPEPLALR LSSNLMIGVT RVWAHQYSFF HSQVSTLHLR VRKELDHFTS 100
    KPFKNIDIQN EQTNPKQLLL AEDPAFIPEV SLYDAFNLPS VDLHVDMSSF 150
    TQPKENPNIS VLETLPDSTS YLINTSQNYS LRNNVSSFVY EDSRAFSTEE 200
    PLDFEFDENG DIQELTKGTI NSDPSLQAAS QHSNLGSVQR EYNSEEQESR 250
    IHMFEIDEDV LPLPVPLQSV MDSEHNENEP RALKRRKVQK LLEPDENIEL 300
    STRTLSQWRK NYVERMIALE ATKYVRRRGA SSAKKKELNK FFDWESFHPL 350
    LKPWIEKLKP SNNTPSEIDD VLRNIDTSEV EVGRDVQGEL GLNIPWNTSS 400
    RSNSAINSKS HSQTGSEHST PLLDTKYRKR LPHSPSMPSR VEFLPALESS 450
    QFHETLNSEL SLQLSDDFVL YKNTQEENAH LMLSMEKECA NFYEYAKTAI 500
    YENNGRITFS SLLPNDLKRP VVAQAFSHLL SLATKSAFLV KQDKPYSEIS 550
    VSLNLKSTDA I 561
    Length:561
    Mass (Da):64,011
    Last modified:January 11, 2001 - v2
    Checksum:iE6B9B3A02143D50A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti531 – 56131SLATK…STDAI → CKYHNQTTN in AAB04034. (PubMed:1339382)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223299 Genomic DNA. Translation: CAA11240.1.
    AB018077 mRNA. Translation: BAA33496.1.
    CU329671 Genomic DNA. Translation: CAA22442.1.
    M85298 Genomic DNA. Translation: AAB04034.1.
    PIRiT43428.
    RefSeqiNP_596059.1. NM_001021970.2.

    Genome annotation databases

    EnsemblFungiiSPBC29A10.14.1; SPBC29A10.14.1:pep; SPBC29A10.14.
    GeneIDi2540458.
    KEGGispo:SPBC29A10.14.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223299 Genomic DNA. Translation: CAA11240.1 .
    AB018077 mRNA. Translation: BAA33496.1 .
    CU329671 Genomic DNA. Translation: CAA22442.1 .
    M85298 Genomic DNA. Translation: AAB04034.1 .
    PIRi T43428.
    RefSeqi NP_596059.1. NM_001021970.2.

    3D structure databases

    ProteinModelPortali P36626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276986. 14 interactions.
    IntActi P36626. 1 interaction.
    MINTi MINT-4689209.
    STRINGi 4896.SPBC29A10.14-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC29A10.14.1 ; SPBC29A10.14.1:pep ; SPBC29A10.14 .
    GeneIDi 2540458.
    KEGGi spo:SPBC29A10.14.

    Organism-specific databases

    PomBasei SPBC29A10.14.

    Phylogenomic databases

    eggNOGi NOG42761.
    KOi K12780.
    OrthoDBi EOG7KSXM4.
    PhylomeDBi P36626.

    Miscellaneous databases

    NextBioi 20801585.

    Family and domain databases

    Gene3Di 1.10.10.580. 1 hit.
    InterProi IPR023093. Rad21/Rec8_C.
    IPR006909. Rad21/Rec8_C_eu.
    IPR006910. Rad21_Rec8_N.
    [Graphical view ]
    Pfami PF04824. Rad21_Rec8. 1 hit.
    PF04825. Rad21_Rec8_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans."
      Parisi S., McKay M.J., Molnar M., Thompson M.A., van der Spek P.J., van Drunen-Schoenmaker E., Kanaar R., Lehmann E., Hoeijmakers J.H.J., Kohli J.
      Mol. Cell. Biol. 19:3515-3528(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, PHOSPHORYLATION.
    2. "Cohesin Rec8 is required for reductional chromosome segregation at meiosis."
      Watanabe Y., Nurse P.
      Nature 400:461-464(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION.
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    4. "Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe."
      Lin Y., Larson K.L., Dorer R., Smith G.R.
      Genetics 132:75-85(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-561.
    5. "The kinetochore protein moa1 enables cohesion-mediated monopolar attachment at meiosis I."
      Yokobayashi S., Watanabe Y.
      Cell 123:803-817(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MOA1.
    6. "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
      Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
      Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MEIOSIS.
    7. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiREC8_SCHPO
    AccessioniPrimary (citable) accession number: P36626
    Secondary accession number(s): O60051
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3