Skip Header

Contribute Send feedback
Read comments (?) or add your own

P36615 (CSK1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase csk1
EC=2.7.11.22
Alternative name(s):
CAK-activating kinase
Short name=CAKAK
Gene names
Name:csk1
ORF Names:SPAC1D4.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex. Ref.3

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Serine/threonine-protein kinase csk1
PRO_0000085881

Regions

Domain11 – 306296Protein kinase
Nucleotide binding17 – 259ATP By similarity

Sites

Active site1291Proton acceptor By similarity
Binding site401ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P36615 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: E670D87547523D0C

FASTA30634,672
        10         20         30         40         50         60 
MKSVGHFVPW LTDIRHLTDG TISEVFVGER KNSKKLYVIK VQGLVFKRPP HDAMRGKLIL 

        70         80         90        100        110        120 
ESIGHPHIER IVDSFIDNEA GSVYLITSFK SFVLSDVMDE ISIDTKCKIV LQISSALEYL 

       130        140        150        160        170        180 
EKHGILHRDI HPNNILLDSM NGPAYLSDFS IAWSKQHPGE EVQELIPQIG TGHYRAIETL 

       190        200        210        220        230        240 
FGCHSYGHEV DRWTFGILIA ELFSNQALFD DGSSEGWPSE LRLTSSIIQT LGTPNPSMWP 

       250        260        270        280        290        300 
ELSTFPDWNK FIFHEYPPKP WSEILPSVDT SIQYIVSHLV TYSNRASPSF VIESFPKVSA 


RLSQYA

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity."
Molz L., Beach D.
EMBO J. 12:1723-1732(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Fission yeast Csk1 is a CAK-activating kinase (CAKAK)."
Hermand D., Pihlak A., Westerling T., Damagnez V., Vandenhaute J., Cottarel G., Makela T.P.
EMBO J. 17:7230-7238(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S59896 Genomic DNA. Translation: AAB26194.1.
CU329670 Genomic DNA. Translation: CAA93215.1.
PIRS39151.
RefSeqNP_593019.1. NM_001018418.1.

3D structure databases

ProteinModelPortalP36615.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC1D4.06c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1D4.06c.1; SPAC1D4.06c.1:pep; SPAC1D4.06c.
GeneID2543327.
KEGGspo:SPAC1D4.06c.

Organism-specific databases

PomBaseSPAC1D4.06c.

Phylogenomic databases

eggNOGCOG0515.
KOK07760.
OrthoDBEOG4V46HW.

Enzyme and pathway databases

BRENDA2.7.11.22. 5615.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804343.

Entry information

Entry nameCSK1_SCHPO
AccessionPrimary (citable) accession number: P36615
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents