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P36615

- CSK1_SCHPO

UniProt

P36615 - CSK1_SCHPO

Protein

Serine/threonine-protein kinase csk1

Gene

csk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401ATPPROSITE-ProRule annotation
    Active sitei129 – 1291Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein kinase activating kinase activity Source: PomBase
    3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    4. protein serine/threonine kinase activity Source: PomBase

    GO - Biological processi

    1. cytoplasmic translational elongation Source: PomBase
    2. positive regulation of protein kinase activity Source: GOC
    3. positive regulation of translational fidelity Source: PomBase
    4. regulation of mitotic cell cycle Source: PomBase
    5. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 5615.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase csk1 (EC:2.7.11.22)
    Alternative name(s):
    CAK-activating kinase
    Short name:
    CAKAK
    Gene namesi
    Name:csk1
    ORF Names:SPAC1D4.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1D4.06c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Serine/threonine-protein kinase csk1PRO_0000085881Add
    BLAST

    Proteomic databases

    MaxQBiP36615.

    Interactioni

    Protein-protein interaction databases

    BioGridi279750. 83 interactions.
    MINTiMINT-4689030.
    STRINGi4896.SPAC1D4.06c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP36615.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 306296Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK07760.
    OMAiHPHIERI.
    OrthoDBiEOG7MWH8H.
    PhylomeDBiP36615.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSVGHFVPW LTDIRHLTDG TISEVFVGER KNSKKLYVIK VQGLVFKRPP    50
    HDAMRGKLIL ESIGHPHIER IVDSFIDNEA GSVYLITSFK SFVLSDVMDE 100
    ISIDTKCKIV LQISSALEYL EKHGILHRDI HPNNILLDSM NGPAYLSDFS 150
    IAWSKQHPGE EVQELIPQIG TGHYRAIETL FGCHSYGHEV DRWTFGILIA 200
    ELFSNQALFD DGSSEGWPSE LRLTSSIIQT LGTPNPSMWP ELSTFPDWNK 250
    FIFHEYPPKP WSEILPSVDT SIQYIVSHLV TYSNRASPSF VIESFPKVSA 300
    RLSQYA 306
    Length:306
    Mass (Da):34,672
    Last modified:June 1, 1994 - v1
    Checksum:iE670D87547523D0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S59896 Genomic DNA. Translation: AAB26194.1.
    CU329670 Genomic DNA. Translation: CAA93215.1.
    PIRiS39151.
    RefSeqiNP_593019.1. NM_001018418.1.

    Genome annotation databases

    EnsemblFungiiSPAC1D4.06c.1; SPAC1D4.06c.1:pep; SPAC1D4.06c.
    GeneIDi2543327.
    KEGGispo:SPAC1D4.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S59896 Genomic DNA. Translation: AAB26194.1 .
    CU329670 Genomic DNA. Translation: CAA93215.1 .
    PIRi S39151.
    RefSeqi NP_593019.1. NM_001018418.1.

    3D structure databases

    ProteinModelPortali P36615.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279750. 83 interactions.
    MINTi MINT-4689030.
    STRINGi 4896.SPAC1D4.06c-1.

    Proteomic databases

    MaxQBi P36615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1D4.06c.1 ; SPAC1D4.06c.1:pep ; SPAC1D4.06c .
    GeneIDi 2543327.
    KEGGi spo:SPAC1D4.06c.

    Organism-specific databases

    PomBasei SPAC1D4.06c.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K07760.
    OMAi HPHIERI.
    OrthoDBi EOG7MWH8H.
    PhylomeDBi P36615.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 5615.

    Miscellaneous databases

    NextBioi 20804343.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity."
      Molz L., Beach D.
      EMBO J. 12:1723-1732(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. Cited for: FUNCTION.

    Entry informationi

    Entry nameiCSK1_SCHPO
    AccessioniPrimary (citable) accession number: P36615
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3