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Protein

Serine/threonine-protein kinase csk1

Gene

csk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATPPROSITE-ProRule annotation
Active sitei129 – 1291Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein kinase activating kinase activity Source: PomBase
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • cyclin-dependent protein serine/threonine kinase regulator activity Source: PomBase
  • protein kinase activator activity Source: PomBase
  • protein kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • meiotic nuclear division Source: PomBase
  • positive regulation of protein kinase activity Source: GOC
  • regulation of protein kinase activity Source: GOC
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase csk1 (EC:2.7.11.22)
Alternative name(s):
CAK-activating kinase
Short name:
CAKAK
Gene namesi
Name:csk1
ORF Names:SPAC1D4.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1D4.06c.
PomBaseiSPAC1D4.06c. csk1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Serine/threonine-protein kinase csk1PRO_0000085881Add
BLAST

Proteomic databases

MaxQBiP36615.

Interactioni

Protein-protein interaction databases

BioGridi279750. 84 interactions.
MINTiMINT-4689030.

Structurei

3D structure databases

ProteinModelPortaliP36615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 306296Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP36615.
KOiK07760.
OrthoDBiEOG7MWH8H.
PhylomeDBiP36615.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVGHFVPW LTDIRHLTDG TISEVFVGER KNSKKLYVIK VQGLVFKRPP
60 70 80 90 100
HDAMRGKLIL ESIGHPHIER IVDSFIDNEA GSVYLITSFK SFVLSDVMDE
110 120 130 140 150
ISIDTKCKIV LQISSALEYL EKHGILHRDI HPNNILLDSM NGPAYLSDFS
160 170 180 190 200
IAWSKQHPGE EVQELIPQIG TGHYRAIETL FGCHSYGHEV DRWTFGILIA
210 220 230 240 250
ELFSNQALFD DGSSEGWPSE LRLTSSIIQT LGTPNPSMWP ELSTFPDWNK
260 270 280 290 300
FIFHEYPPKP WSEILPSVDT SIQYIVSHLV TYSNRASPSF VIESFPKVSA

RLSQYA
Length:306
Mass (Da):34,672
Last modified:June 1, 1994 - v1
Checksum:iE670D87547523D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59896 Genomic DNA. Translation: AAB26194.1.
CU329670 Genomic DNA. Translation: CAA93215.1.
PIRiS39151.
RefSeqiNP_593019.1. NM_001018418.1.

Genome annotation databases

EnsemblFungiiSPAC1D4.06c.1; SPAC1D4.06c.1:pep; SPAC1D4.06c.
GeneIDi2543327.
KEGGispo:SPAC1D4.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59896 Genomic DNA. Translation: AAB26194.1.
CU329670 Genomic DNA. Translation: CAA93215.1.
PIRiS39151.
RefSeqiNP_593019.1. NM_001018418.1.

3D structure databases

ProteinModelPortaliP36615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279750. 84 interactions.
MINTiMINT-4689030.

Proteomic databases

MaxQBiP36615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1D4.06c.1; SPAC1D4.06c.1:pep; SPAC1D4.06c.
GeneIDi2543327.
KEGGispo:SPAC1D4.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1D4.06c.
PomBaseiSPAC1D4.06c. csk1.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP36615.
KOiK07760.
OrthoDBiEOG7MWH8H.
PhylomeDBiP36615.

Enzyme and pathway databases

BRENDAi2.7.11.22. 5613.

Miscellaneous databases

NextBioi20804343.
PROiP36615.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity."
    Molz L., Beach D.
    EMBO J. 12:1723-1732(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiCSK1_SCHPO
AccessioniPrimary (citable) accession number: P36615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.