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Protein

Serine/threonine-protein phosphatase ppe1

Gene

ppe1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi111Manganese 2By similarity1
Active sitei112Proton donorBy similarity1
Metal bindingi161Manganese 2By similarity1
Metal bindingi235Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: PomBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • mitotic nuclear division Source: UniProtKB-KW
  • positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: PomBase
  • positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: PomBase
  • regulation of mitotic sister chromatid segregation Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Cell shape, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase ppe1 (EC:3.1.3.16)
Alternative name(s):
Phosphatase esp1
Gene namesi
Name:ppe1
Synonyms:esp1, ppx1
ORF Names:SPCC1739.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.12.
PomBaseiSPCC1739.12. ppe1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associated with chromatin.

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588821 – 305Serine/threonine-protein phosphatase ppe1Add BLAST305

Proteomic databases

MaxQBiP36614.
PRIDEiP36614.

Interactioni

Subunit structurei

Interacts with sts5, ekc1 and mis12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ekc1O745112EBI-1153118,EBI-1153096

Protein-protein interaction databases

BioGridi275341. 31 interactors.
IntActiP36614. 2 interactors.
MINTiMINT-4689011.

Structurei

3D structure databases

ProteinModelPortaliP36614.
SMRiP36614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
KOiK15427.
OMAiEQAKQCK.
OrthoDBiEOG092C2R40.
PhylomeDBiP36614.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P36614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDLDEWIAT VRKCKYLPEH QLKRLCEMVK VILMEESNIQ PVRTPVTVCG
60 70 80 90 100
DIHGQFYDLL ELFRVGGELP STNYIFMGDF VDRGYFSLET FTLFMLLKAR
110 120 130 140 150
YPDKITLLRG NHESRQITQV YGFYDECQTK YGNANVWKYC CQVFDFLTLA
160 170 180 190 200
AVIDNKILCV HGGLSPEVRT LDQIRILARA QEIPHEGSFC DLMWSDPEDI
210 220 230 240 250
ESWTVSPRGA GWLFGSKVTT EFSQINDLTL IARAHQLVQE GYKYHFADKN
260 270 280 290 300
LVTVWSAPNY CYRCGNVASV MKVDESLEPE FRIFSAVADE DRTVPPSRKR

SEYFI
Length:305
Mass (Da):35,259
Last modified:June 1, 1994 - v1
Checksum:i001980A1CC7646D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13712 Genomic DNA. Translation: BAA02865.1.
Z18925 Genomic DNA. Translation: CAA79358.1.
CU329672 Genomic DNA. Translation: CAA20786.1.
PIRiA47727.
RefSeqiNP_588420.1. NM_001023411.2.

Genome annotation databases

EnsemblFungiiSPCC1739.12.1; SPCC1739.12.1:pep; SPCC1739.12.
GeneIDi2538758.
KEGGispo:SPCC1739.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13712 Genomic DNA. Translation: BAA02865.1.
Z18925 Genomic DNA. Translation: CAA79358.1.
CU329672 Genomic DNA. Translation: CAA20786.1.
PIRiA47727.
RefSeqiNP_588420.1. NM_001023411.2.

3D structure databases

ProteinModelPortaliP36614.
SMRiP36614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275341. 31 interactors.
IntActiP36614. 2 interactors.
MINTiMINT-4689011.

Proteomic databases

MaxQBiP36614.
PRIDEiP36614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1739.12.1; SPCC1739.12.1:pep; SPCC1739.12.
GeneIDi2538758.
KEGGispo:SPCC1739.12.

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.12.
PomBaseiSPCC1739.12. ppe1.

Phylogenomic databases

HOGENOMiHOG000172696.
KOiK15427.
OMAiEQAKQCK.
OrthoDBiEOG092C2R40.
PhylomeDBiP36614.

Miscellaneous databases

PROiPR:P36614.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPE1_SCHPO
AccessioniPrimary (citable) accession number: P36614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 15, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.