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Protein

Cyclin mcs2

Gene

mcs2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for progression through the cell cycle. Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-SPO-113418 Formation of the Early Elongation Complex
R-SPO-5696395 Formation of Incision Complex in GG-NER
R-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SPO-72086 mRNA Capping
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin mcs2
Alternative name(s):
Mitotic catastrophe suppressor 2
Gene namesi
Name:mcs2
ORF Names:SPBP16F5.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP16F5.02
PomBaseiSPBP16F5.02 mcs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805051 – 322Cyclin mcs2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36613
PaxDbiP36613
PRIDEiP36613

PTM databases

iPTMnetiP36613

Interactioni

Subunit structurei

One of the nine subunits forming the core-TFIIH basal transcription factor. Interacts with crk1 and skp1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
skp1Q9Y7093EBI-1168694,EBI-1172248

Protein-protein interaction databases

BioGridi277082, 171 interactors
IntActiP36613, 3 interactors
STRINGi4896.SPBP16F5.02.1

Structurei

3D structure databases

ProteinModelPortaliP36613
SMRiP36613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000197843
InParanoidiP36613
KOiK06634
OMAiNYYLTIH
OrthoDBiEOG092C3VA4
PhylomeDBiP36613

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit

Sequencei

Sequence statusi: Complete.

P36613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADKFRDST HYRDWIFTEE DLSKTRAKVN EKFTNIVRER MLEELSLQNK
60 70 80 90 100
EASLEVLPPT LTVEEELELV NYYSFQLNAL SSALSLPTHI RSTAILFFKR
110 120 130 140 150
FYLINSVMEY SPKIISFTSL FLATKCNDHY ISIEQFCKNM PKTTPEEVLE
160 170 180 190 200
YEFNVCQSLK WDLYVWLPFR PLQGFLLDCQ TVLPKVAVEK FYECHDLSKK
210 220 230 240 250
FLIETLHSDI YFLHSPSIIA LGAIYHTNPT ICLQYIEAKK IPELQPLIIS
260 270 280 290 300
ISANLKATKK FKIEKKKAQD YGRKLYFCMN PLRNKSSALY LKRKAEEEST
310 320
NNNKWAKKFS TSSNVLDKNP FE
Length:322
Mass (Da):37,674
Last modified:June 1, 1994 - v1
Checksum:i09B8DDB46563727C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59895 Genomic DNA Translation: AAB26193.1
CU329671 Genomic DNA Translation: CAC08541.1
PIRiS35380
RefSeqiNP_595776.1, NM_001021676.2

Genome annotation databases

EnsemblFungiiSPBP16F5.02.1; SPBP16F5.02.1:pep; SPBP16F5.02
GeneIDi2540555
KEGGispo:SPBP16F5.02

Similar proteinsi

Entry informationi

Entry nameiCGM2_SCHPO
AccessioniPrimary (citable) accession number: P36613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health