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Protein

26S proteasome regulatory subunit 4 homolog

Gene

mts2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 239ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SPO-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 4 homolog
Alternative name(s):
Protein mts2
Gene namesi
Name:mts2
ORF Names:SPBC4.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4.07c.
PomBaseiSPBC4.07c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • cytosolic proteasome complex Source: GO_Central
  • nuclear chromatin Source: PomBase
  • nuclear proteasome complex Source: GO_Central
  • nucleus Source: PomBase
  • proteasome regulatory particle, base subcomplex Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846841 – 44826S proteasome regulatory subunit 4 homologAdd BLAST448

Proteomic databases

MaxQBiP36612.
PRIDEiP36612.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277455. 22 interactors.
IntActiP36612. 1 interactor.
MINTiMINT-4688995.
STRINGi4896.SPBC4.07c.1.

Structurei

3D structure databases

ProteinModelPortaliP36612.
SMRiP36612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiP36612.
KOiK03062.
OMAiNATFIRV.
OrthoDBiEOG092C19WS.
PhylomeDBiP36612.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035244. PSMC1.
PANTHERiPTHR23073:SF40. PTHR23073:SF40. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

P36612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQAQSGNFS NFGDGANGDN KKDQKKDKPK YEPPVPTRTG RRKKKAQSGP
60 70 80 90 100
DASAKLPTVI PTTRCRLRLL KMQRIHDHLL MEEEYVQNQE RLKPQDERTQ
110 120 130 140 150
EERNRVDEIR GTPMSVGTLE EIIDDDHAIV STAGPEYYVS IMSFVDKDML
160 170 180 190 200
EPGCSVLLHH KAMSIVGLLL DDTDPMINVM KLDKAPTESY ADIGGLESQI
210 220 230 240 250
QEIKEAVELP LTHPELYEEM GIKPPKGVIL YGAPGTGKTL LAKAVANQTS
260 270 280 290 300
ATFLRVVGSE LIQKYLGDGP RLVRQLFNAA EEHSPSIVFI DEIDAIGTKR
310 320 330 340 350
YDAQSGAERE IQRTMLELLN QLDGFDTSQR DIKVIMATNR ISDLDPALIR
360 370 380 390 400
PGRIDRKILF ENPDEATKRK IFTIHTSKMN LGEDVNLEEL IQCKDDLSGA
410 420 430 440
EIKAIVSEAG LLALRERRMR VVMDDFRQAR EKVLKTKDEG GPAGGLYI
Length:448
Mass (Da):50,060
Last modified:June 1, 1994 - v1
Checksum:i451AEEF6A24C29D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29366 mRNA. Translation: CAA82554.1.
CU329671 Genomic DNA. Translation: CAB58406.1.
PIRiS39348.
RefSeqiNP_595480.1. NM_001021391.2.

Genome annotation databases

EnsemblFungiiSPBC4.07c.1; SPBC4.07c.1:pep; SPBC4.07c.
GeneIDi2540939.
KEGGispo:SPBC4.07c.

Similar proteinsi

Entry informationi

Entry nameiPRS4_SCHPO
AccessioniPrimary (citable) accession number: P36612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 30, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families