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Protein

Na(+)/H(+) antiporter

Gene

sod2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium export from cell, takes up external protons in exchange for internal sodium ions. Involved in regulation of pH.

GO - Molecular functioni

  • sodium:proton antiporter activity Source: PomBase

GO - Biological processi

  • cellular potassium ion homeostasis Source: GO_Central
  • cellular sodium ion homeostasis Source: PomBase
  • intracellular pH reduction Source: PomBase
  • proton transmembrane transport Source: PomBase
  • sodium ion export across plasma membrane Source: PomBase

Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.36.1.21 the monovalent cation:proton antiporter-1 (cpa1) family
2.A.36.4.3 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) antiporter
Gene namesi
Name:sod2
ORF Names:SPAC977.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC977.10
PomBaseiSPAC977.10 sod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei81 – 96HelicalSequence analysisAdd BLAST16
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000524051 – 468Na(+)/H(+) antiporterAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei449Phosphoserine1 Publication1
Modified residuei451Phosphoserine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP36606
PaxDbiP36606
PRIDEiP36606

PTM databases

iPTMnetiP36606

Interactioni

Protein-protein interaction databases

BioGridi279667, 6 interactors
STRINGi4896.SPAC977.10.1

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi130 – 142Combined sources13
Helixi147 – 152Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M7XNMR-A125-154[»]
SMRiP36606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fungal Na(+)/H(+) exchanger family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP36606
OMAiPRSWGSH
OrthoDBiEOG092C2DRG
PhylomeDBiP36606

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR004712 Na+/H+_antiporter_fungi
PANTHERiPTHR31382:SF4 PTHR31382:SF4, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit

Sequencei

Sequence statusi: Complete.

P36606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWRQLDIDK VHLALIVAGG FITFFCYFSE VFRKKLLVGE AVLGSITGLI
60 70 80 90 100
FGPHAAKLVD PFSWGDHGDY LTVEICRIVL DVRVFASAIE LPGAYFQHNF
110 120 130 140 150
RSIIVMLLPV MAYGWLVTAG FAYALFPQIN FLGSLLIAGC ITSTDPVLSA
160 170 180 190 200
LIVGEGPLAK KTPERIRSLL IAESGCNDGM AVPFFYFAIK LLTVKPSRNA
210 220 230 240 250
GRDWVLLVVL YECAFGIFFG CVIGYLLSFI LKHAQKYRLI DAISYYSLPL
260 270 280 290 300
AIPLLCSGIG TIIGVDDLLM SFFAGILFNW NDLFSKNISA CSVPAFIDQT
310 320 330 340 350
FSLLFFTYYG TIIPWNNFNW SVEGLPVWRL IVFSILTLVC RRLPVVFSVK
360 370 380 390 400
PLVPDIKTWK EALFVGHFGP IGVCAVYMAF LAKLLLSPDE IEKSIYESTT
410 420 430 440 450
VFSTLNEIIW PIISFVILSS IIVHGFSIHV LVIWGKLKSL YLNRKVTKSD
460
SDLELQVIGV DKSQEDYV
Length:468
Mass (Da):52,177
Last modified:June 1, 1994 - v1
Checksum:i04908860E57B9069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11736 Genomic DNA Translation: CAA77796.1
CU329670 Genomic DNA Translation: CAB69632.1
PIRiS20951
RefSeqiNP_592782.1, NM_001018182.2

Genome annotation databases

EnsemblFungiiSPAC977.10.1; SPAC977.10.1:pep; SPAC977.10
GeneIDi2543239
KEGGispo:SPAC977.10

Similar proteinsi

Entry informationi

Entry nameiNAH_SCHPO
AccessioniPrimary (citable) accession number: P36606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health