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Protein

Na(+)/H(+) antiporter

Gene

sod2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium export from cell, takes up external protons in exchange for internal sodium ions. Involved in regulation of pH.

GO - Molecular functioni

  • sodium:proton antiporter activity Source: PomBase

GO - Biological processi

  • cellular potassium ion homeostasis Source: GO_Central
  • cellular sodium ion homeostasis Source: PomBase
  • hydrogen ion transmembrane transport Source: PomBase
  • intracellular pH reduction Source: PomBase
  • sodium ion export from cell Source: PomBase
  • sodium ion import into cell Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.36.4.3. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) antiporter
Gene namesi
Name:sod2
ORF Names:SPAC977.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC977.10.
PomBaseiSPAC977.10. sod2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei81 – 9616HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: PomBase
  • nuclear outer membrane-endoplasmic reticulum membrane network Source: PomBase
  • perinuclear endoplasmic reticulum membrane Source: PomBase
  • plasma membrane Source: PomBase
  • plasma membrane of cell tip Source: PomBase
  • prospore membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Na(+)/H(+) antiporterPRO_0000052405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence analysis
Modified residuei449 – 4491Phosphoserine1 Publication
Modified residuei451 – 4511Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP36606.

PTM databases

iPTMnetiP36606.

Interactioni

Protein-protein interaction databases

BioGridi279667. 5 interactions.
MINTiMINT-4688958.

Structurei

Secondary structure

1
468
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi130 – 14213Combined sources
Helixi147 – 1526Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M7XNMR-A125-154[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fungal Na(+)/H(+) exchanger family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP36606.
OMAiFFGYVSM.
OrthoDBiEOG7PVWZ7.
PhylomeDBiP36606.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR004712. Na+/H+_antiporter_fungi.
[Graphical view]
PANTHERiPTHR31382:SF4. PTHR31382:SF4. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWRQLDIDK VHLALIVAGG FITFFCYFSE VFRKKLLVGE AVLGSITGLI
60 70 80 90 100
FGPHAAKLVD PFSWGDHGDY LTVEICRIVL DVRVFASAIE LPGAYFQHNF
110 120 130 140 150
RSIIVMLLPV MAYGWLVTAG FAYALFPQIN FLGSLLIAGC ITSTDPVLSA
160 170 180 190 200
LIVGEGPLAK KTPERIRSLL IAESGCNDGM AVPFFYFAIK LLTVKPSRNA
210 220 230 240 250
GRDWVLLVVL YECAFGIFFG CVIGYLLSFI LKHAQKYRLI DAISYYSLPL
260 270 280 290 300
AIPLLCSGIG TIIGVDDLLM SFFAGILFNW NDLFSKNISA CSVPAFIDQT
310 320 330 340 350
FSLLFFTYYG TIIPWNNFNW SVEGLPVWRL IVFSILTLVC RRLPVVFSVK
360 370 380 390 400
PLVPDIKTWK EALFVGHFGP IGVCAVYMAF LAKLLLSPDE IEKSIYESTT
410 420 430 440 450
VFSTLNEIIW PIISFVILSS IIVHGFSIHV LVIWGKLKSL YLNRKVTKSD
460
SDLELQVIGV DKSQEDYV
Length:468
Mass (Da):52,177
Last modified:June 1, 1994 - v1
Checksum:i04908860E57B9069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11736 Genomic DNA. Translation: CAA77796.1.
CU329670 Genomic DNA. Translation: CAB69632.1.
PIRiS20951.
RefSeqiNP_592782.1. NM_001018182.2.

Genome annotation databases

EnsemblFungiiSPAC977.10.1; SPAC977.10.1:pep; SPAC977.10.
GeneIDi2543239.
KEGGispo:SPAC977.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11736 Genomic DNA. Translation: CAA77796.1.
CU329670 Genomic DNA. Translation: CAB69632.1.
PIRiS20951.
RefSeqiNP_592782.1. NM_001018182.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M7XNMR-A125-154[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279667. 5 interactions.
MINTiMINT-4688958.

Protein family/group databases

TCDBi2.A.36.4.3. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

iPTMnetiP36606.

Proteomic databases

MaxQBiP36606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC977.10.1; SPAC977.10.1:pep; SPAC977.10.
GeneIDi2543239.
KEGGispo:SPAC977.10.

Organism-specific databases

EuPathDBiFungiDB:SPAC977.10.
PomBaseiSPAC977.10. sod2.

Phylogenomic databases

InParanoidiP36606.
OMAiFFGYVSM.
OrthoDBiEOG7PVWZ7.
PhylomeDBiP36606.

Miscellaneous databases

PROiP36606.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR004712. Na+/H+_antiporter_fungi.
[Graphical view]
PANTHERiPTHR31382:SF4. PTHR31382:SF4. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast."
    Jia Z.-P., McCullough N., Martel R., Hemmingsen S., Young P.G.
    EMBO J. 11:1631-1640(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification and localization of the sod2 gene product in fission yeast."
    Dibrov P., Smith J.J., Young P.G., Fliegel L.
    FEBS Lett. 405:119-124(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449 AND SER-451, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNAH_SCHPO
AccessioniPrimary (citable) accession number: P36606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.