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Protein

Histidinol-phosphate aminotransferase

Gene

his3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (his1)
  2. Histidine biosynthesis bifunctional protein his7 (his7)
  3. Histidine biosynthesis bifunctional protein his7 (his7)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (SPAC3F10.09)
  5. Imidazole glycerol phosphate synthase hisHF (his4)
  6. Imidazoleglycerol-phosphate dehydratase (his5)
  7. Histidinol-phosphate aminotransferase (his3)
  8. Probable histidinol-phosphatase (SPCC1672.01)
  9. Histidinol dehydrogenase (his2)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • histidine biosynthetic process Source: PomBase
  • response to nickel cation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:his3
ORF Names:pi009, SPBC11B10.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC11B10.02c.
PomBaseiSPBC11B10.02c. his3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001535081 – 384Histidinol-phosphate aminotransferaseAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223N6-(pyridoxal phosphate)lysineCurated1

Proteomic databases

MaxQBiP36605.
PRIDEiP36605.

Interactioni

Protein-protein interaction databases

MINTiMINT-4688940.

Structurei

3D structure databases

ProteinModelPortaliP36605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000288512.
InParanoidiP36605.
KOiK00817.
OMAiIKPPYNI.
OrthoDBiEOG092C2LVP.
PhylomeDBiP36605.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDLNTCLRK NILELQPYRC ARDDFSEGVL LDANECAYGS VISVDGVEFN
60 70 80 90 100
RYPDPRQIEV KQRLCDLRNK ELSITKPLTP DNICMGVGSD EIIDSLIRIS
110 120 130 140 150
CIPGKDKILM CPPSYGMYTV SAKINDVEVV KVLLEPDFNL NVDAICETLS
160 170 180 190 200
KDSAIKVFFA CSPGNPTAKA LKLEDIKKIL EHPTWNGIVV VDEAYIDFSA
210 220 230 240 250
PDMSALTLVN EYPNLAVCQT LSKSFGLAGI RIGFCLTSKP IATIMNSLKA
260 270 280 290 300
PYNISEPTSR LALDALSPQS IDKMHTYRDA IIQQRVRLCK ELTTIKGMGK
310 320 330 340 350
IIGGYDANFI LIQVLDRPEG GKPSNDAAKY LYLQMATMHK VVVRFRGTEP
360 370 380
LCEGALRITV GTEEENTILL KTIKLVLQEY YTKK
Length:384
Mass (Da):42,734
Last modified:June 1, 1994 - v1
Checksum:i83E02A8E46B5E122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19523 Genomic DNA. Translation: AAA67316.1.
L19524 Genomic DNA. Translation: AAA86664.1.
AB004534 Genomic DNA. Translation: BAA21386.1.
CU329671 Genomic DNA. Translation: CAC37506.1.
PIRiS41584.
RefSeqiNP_595622.1. NM_001021516.2.

Genome annotation databases

EnsemblFungiiSPBC11B10.02c.1; SPBC11B10.02c.1:pep; SPBC11B10.02c.
GeneIDi2539698.
KEGGispo:SPBC11B10.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19523 Genomic DNA. Translation: AAA67316.1.
L19524 Genomic DNA. Translation: AAA86664.1.
AB004534 Genomic DNA. Translation: BAA21386.1.
CU329671 Genomic DNA. Translation: CAC37506.1.
PIRiS41584.
RefSeqiNP_595622.1. NM_001021516.2.

3D structure databases

ProteinModelPortaliP36605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4688940.

Proteomic databases

MaxQBiP36605.
PRIDEiP36605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC11B10.02c.1; SPBC11B10.02c.1:pep; SPBC11B10.02c.
GeneIDi2539698.
KEGGispo:SPBC11B10.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC11B10.02c.
PomBaseiSPBC11B10.02c. his3.

Phylogenomic databases

HOGENOMiHOG000288512.
InParanoidiP36605.
KOiK00817.
OMAiIKPPYNI.
OrthoDBiEOG092C2LVP.
PhylomeDBiP36605.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.

Miscellaneous databases

PROiP36605.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIS8_SCHPO
AccessioniPrimary (citable) accession number: P36605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 5, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.