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Protein

78 kDa glucose-regulated protein homolog

Gene

bip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_287431. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:bip1
Synonyms:bip
ORF Names:SPAC22A12.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22A12.15c.
PomBaseiSPAC22A12.15c. bip1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: CACAO
  • endoplasmic reticulum lumen Source: PomBase
  • Golgi apparatus Source: PomBase
  • nuclear membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 66363978 kDa glucose-regulated protein homologPRO_0000013585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Partially N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP36604.
PaxDbiP36604.
PRIDEiP36604.

Interactioni

Protein-protein interaction databases

BioGridi278306. 4 interactions.
IntActiP36604. 2 interactions.
MINTiMINT-4688922.

Structurei

3D structure databases

ProteinModelPortaliP36604.
SMRiP36604. Positions 35-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi660 – 6634Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP36604.
KOiK09490.
OMAiHANDTEA.
OrthoDBiEOG728916.
PhylomeDBiP36604.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA
60 70 80 90 100
VMKNGRVEII ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD
110 120 130 140 150
IKRLIGRKFD EKTMAKDIKS FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI
160 170 180 190 200
SAMILSKMKQ TAEAYLGKPV THAVVTVPAY FNDAQRQATK DAGTIAGLNV
210 220 230 240 250
IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL SIDNGVFEVL
260 270 280 290 300
ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA
310 320 330 340 350
KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV
360 370 380 390 400
LKDSNLKKSE IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY
410 420 430 440 450
GAAVQAGVLS GEEGSDNIVL LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR
460 470 480 490 500
KSQIFSTAVD NQNTVLIQVY EGERTLTKDN NLLGKFDLRG IPPAPRGVPQ
510 520 530 540 550
IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE EDIERMVKEA
560 570 580 590 600
EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGGK VDPEDKQAVL
610 620 630 640 650
DAVEDVAEWL EIHGEDASKE EFEDQRQKLD AVVHPITQKL YSEGAGDADE
660
EDDDYFDDEA DEL
Length:663
Mass (Da):73,227
Last modified:December 15, 1998 - v2
Checksum:i9DB80112E6C35742
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731A → S in CAA45762 (PubMed:1373379).Curated
Sequence conflicti301 – 3022KR → NG in CAA45762 (PubMed:1373379).Curated
Sequence conflicti336 – 34510NMDLFKKTLK → KHGSLQEDFE in CAA45762 (PubMed:1373379).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64416 Genomic DNA. Translation: CAA45762.1.
CU329670 Genomic DNA. Translation: CAB16585.1.
PIRiS20877.
T38155.
RefSeqiNP_593245.1. NM_001018642.2.

Genome annotation databases

EnsemblFungiiSPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c.
GeneIDi2541815.
KEGGispo:SPAC22A12.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64416 Genomic DNA. Translation: CAA45762.1.
CU329670 Genomic DNA. Translation: CAB16585.1.
PIRiS20877.
T38155.
RefSeqiNP_593245.1. NM_001018642.2.

3D structure databases

ProteinModelPortaliP36604.
SMRiP36604. Positions 35-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278306. 4 interactions.
IntActiP36604. 2 interactions.
MINTiMINT-4688922.

Proteomic databases

MaxQBiP36604.
PaxDbiP36604.
PRIDEiP36604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c.
GeneIDi2541815.
KEGGispo:SPAC22A12.15c.

Organism-specific databases

EuPathDBiFungiDB:SPAC22A12.15c.
PomBaseiSPAC22A12.15c. bip1.

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP36604.
KOiK09490.
OMAiHANDTEA.
OrthoDBiEOG728916.
PhylomeDBiP36604.

Enzyme and pathway databases

ReactomeiREACT_287431. Platelet degranulation.

Miscellaneous databases

NextBioi20802903.
PROiP36604.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe."
    Pidoux A.L., Armstrong J.
    EMBO J. 11:1583-1591(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGRP78_SCHPO
AccessioniPrimary (citable) accession number: P36604
Secondary accession number(s): O13906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: July 22, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.