UniProtKB - P36604 (BIP_SCHPO)
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Protein
Endoplasmic reticulum chaperone BiP
Gene
bip1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.By similarity
Enzyme regulationi
The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 102 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 43 – 46 | ATPBy similarity | 4 | |
Nucleotide bindingi | 232 – 234 | ATPBy similarity | 3 | |
Nucleotide bindingi | 298 – 305 | ATPBy similarity | 8 | |
Nucleotide bindingi | 369 – 372 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATPase activity Source: PomBase
- ATP binding Source: PomBase
- unfolded protein binding Source: PomBase
GO - Biological processi
- cellular response to unfolded protein Source: PomBase
- endoplasmic reticulum unfolded protein response Source: PomBase
- ubiquitin-dependent ERAD pathway Source: PomBase
Keywordsi
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-3371453 Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum chaperone BiPCuratedAlternative name(s): Immunoglobulin heavy chain-binding protein homologCurated Short name: BiPCurated |
Gene namesi | Name:bip1 Synonyms:bip ORF Names:SPAC22A12.15c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC22A12.15c |
PomBasei | SPAC22A12.15c bip1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000013585 | 25 – 663 | Endoplasmic reticulum chaperone BiPAdd BLAST | 639 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Partially N-glycosylated.
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P36604 |
PaxDbi | P36604 |
PRIDEi | P36604 |
PTM databases
iPTMneti | P36604 |
Interactioni
GO - Molecular functioni
- unfolded protein binding Source: PomBase
Protein-protein interaction databases
BioGridi | 2783064 interactors. |
ELMi | P36604 |
IntActi | P36604 2 interactors. |
STRINGi | 4896.SPAC22A12.15c.1 |
Structurei
3D structure databases
ProteinModelPortali | P36604 |
SMRi | P36604 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 131 – 285 | Nucleotide-binding (NBD)By similarityAdd BLAST | 155 | |
Regioni | 404 – 504 | Substrate-binding (SBD)By similarityAdd BLAST | 101 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 660 – 663 | Prevents secretion from ER | 4 |
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | HOG000228135 |
InParanoidi | P36604 |
KOi | K09490 |
OMAi | CVGVMQK |
OrthoDBi | EOG092C1VPN |
PhylomeDBi | P36604 |
Family and domain databases
Gene3Di | 1.20.1270.101 hit 2.60.34.101 hit |
InterProi | View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam |
PANTHERi | PTHR19375 PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012 HSP70, 1 hit |
PRINTSi | PR00301 HEATSHOCK70 |
SUPFAMi | SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit |
PROSITEi | View protein in PROSITE PS00014 ER_TARGET, 1 hit PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P36604-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA
60 70 80 90 100
VMKNGRVEII ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD
110 120 130 140 150
IKRLIGRKFD EKTMAKDIKS FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI
160 170 180 190 200
SAMILSKMKQ TAEAYLGKPV THAVVTVPAY FNDAQRQATK DAGTIAGLNV
210 220 230 240 250
IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL SIDNGVFEVL
260 270 280 290 300
ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA
310 320 330 340 350
KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV
360 370 380 390 400
LKDSNLKKSE IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY
410 420 430 440 450
GAAVQAGVLS GEEGSDNIVL LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR
460 470 480 490 500
KSQIFSTAVD NQNTVLIQVY EGERTLTKDN NLLGKFDLRG IPPAPRGVPQ
510 520 530 540 550
IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE EDIERMVKEA
560 570 580 590 600
EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGGK VDPEDKQAVL
610 620 630 640 650
DAVEDVAEWL EIHGEDASKE EFEDQRQKLD AVVHPITQKL YSEGAGDADE
660
EDDDYFDDEA DEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | A → S in CAA45762 (PubMed:1373379).Curated | 1 | |
Sequence conflicti | 301 – 302 | KR → NG in CAA45762 (PubMed:1373379).Curated | 2 | |
Sequence conflicti | 336 – 345 | NMDLFKKTLK → KHGSLQEDFE in CAA45762 (PubMed:1373379).Curated | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64416 Genomic DNA Translation: CAA45762.1 CU329670 Genomic DNA Translation: CAB16585.1 |
PIRi | S20877 T38155 |
RefSeqi | NP_593245.1, NM_001018642.2 |
Genome annotation databases
EnsemblFungii | SPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c |
GeneIDi | 2541815 |
KEGGi | spo:SPAC22A12.15c |
Similar proteinsi
Entry informationi
Entry namei | BIP_SCHPO | |
Accessioni | P36604Primary (citable) accession number: P36604 Secondary accession number(s): O13906 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 28, 2018 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |