P36604 (GRP78_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 107.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 78 kDa glucose-regulated protein homolog Short name=GRP-78 Alternative name(s): Immunoglobulin heavy chain-binding protein homolog Short name=BiP | ||||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 284812 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›  |
Protein attributes
| Sequence length | 663 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. |
| Subcellular location | |
| Post-translational modification | Partially N-glycosylated. |
| Sequence similarities | Belongs to the heat shock protein 70 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Cellular component | Endoplasmic reticulum |
| Domain | Signal |
| Ligand | ATP-binding Nucleotide-binding |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | 'de novo' posttranslational protein folding Inferred from direct assay PubMed 9860839. Source: PomBase ER-associated protein catabolic processInferred from sequence orthology. Source: PomBase cellular response to unfolded proteinInferred from sequence orthology. Source: PomBase |
| Cellular_component | Golgi apparatus Inferred from direct assay PubMed 16823372. Source: PomBase endoplasmic reticulum lumenInferred from direct assay Ref.1. Source: PomBase nuclear membraneInferred from direct assay Ref.1. Source: PomBase |
| Molecular_function | ATP binding Inferred by curator. Source: PomBase ATPase activityInferred from sequence orthology. Source: PomBase unfolded protein bindingInferred from sequence orthology. Source: PomBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||
| Chain | 25 – 663 | 639 | 78 kDa glucose-regulated protein homolog | PRO_0000013585 | |||||
Regions | |||||||||
| Motif | 660 – 663 | 4 | Prevents secretion from ER | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 29 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 173 | 1 | A → S in CAA45762. Ref.1 | ||||||
| Sequence conflict | 301 – 302 | 2 | KR → NG in CAA45762. Ref.1 | ||||||
| Sequence conflict | 336 – 345 | 10 | NMDLFKKTLK → KHGSLQEDFE in CAA45762. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe." Pidoux A.L., Armstrong J. EMBO J. 11:1583-1591(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X64416 Genomic DNA. Translation: CAA45762.1. CU329670 Genomic DNA. Translation: CAB16585.1. |
| PIR | S20877. T38155. |
| RefSeq | NP_593245.1. NM_001018642.2. |
3D structure databases | |
| ProteinModelPortal | P36604. |
| SMR | P36604. Positions 35-575. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P36604. 2 interactions. |
| MINT | MINT-4688922. |
| STRING | 4896.SPAC22A12.15c-1. |
Proteomic databases | |
| PaxDb | P36604. |
| PRIDE | P36604. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c. |
| GeneID | 2541815. |
| KEGG | spo:SPAC22A12.15c. |
Organism-specific databases | |
| PomBase | SPAC22A12.15c. |
Phylogenomic databases | |
| eggNOG | COG0443. |
| HOGENOM | HOG000228135. |
| KO | K09490. |
| OMA | PENTIYA. |
| OrthoDB | EOG4X0R1M. |
Family and domain databases | |
| InterPro | IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view] |
| Pfam | PF00012. HSP70. 1 hit. [Graphical view] |
| PRINTS | PR00301. HEATSHOCK70. |
| PROSITE | PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20802903. |
Entry information
| Entry name | GRP78_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P36604 Secondary accession number(s): O13906 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |