bip1

Functionⁱ

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.By similarity

Enzyme regulationⁱ

The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	102	ATPBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	43 – 46	ATPBy similarity	4
Nucleotide bindingⁱ	232 – 234	ATPBy similarity	3
Nucleotide bindingⁱ	298 – 305	ATPBy similarity	8
Nucleotide bindingⁱ	369 – 372	ATPBy similarity	4

GO - Molecular functionⁱ

ATPase activity Source: PomBase
ATP binding Source: PomBase
unfolded protein binding Source: PomBase

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoplasmic reticulum unfolded protein response
Source: PomBase
Inferred from mutant phenotypeⁱ
- 23066505
ubiquitin-dependent ERAD pathway Source: PomBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Stress response
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-SPO-3371453 Regulation of HSF1-mediated heat shock response

Reactomeⁱ

R-SPO-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endoplasmic reticulum chaperone BiPCurated Alternative name(s): Immunoglobulin heavy chain-binding protein homologCurated Short name: BiPCurated
Gene namesⁱ	Name:bip1 Synonyms:bip ORF Names:SPAC22A12.15c
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome I

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC22A12.15c
PomBaseⁱ	SPAC22A12.15c bip1

Keywords - Cellular componentⁱ

Endoplasmic reticulum

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000013585	25 – 663	Endoplasmic reticulum chaperone BiPAdd BLAST		639

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Partially N-glycosylated.

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36604
PaxDbⁱ	P36604
PRIDEⁱ	P36604

PTM databases

iPTMnetⁱ	P36604

iPTMnetⁱ

P36604

Interactionⁱ

GO - Molecular functionⁱ

unfolded protein binding Source: PomBase

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	278306, 4 interactors
ELMⁱ	P36604
IntActⁱ	P36604, 2 interactors
STRINGⁱ	4896.SPAC22A12.15c.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P36604
SMRⁱ	P36604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	131 – 285	Nucleotide-binding (NBD)By similarityAdd BLAST		155
Regionⁱ	404 – 504	Substrate-binding (SBD)By similarityAdd BLAST		101

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	660 – 663	Prevents secretion from ER		4

Sequence similaritiesⁱ

Belongs to the heat shock protein 70 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOGENOMⁱ	HOG000228135
InParanoidⁱ	P36604
KEGG Orthology (KO) More...KOⁱ	K09490
OMAⁱ	CVGVMQK
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1VPN
PhylomeDBⁱ	P36604

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012 HSP70, 1 hit
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P36604-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA 
        60         70         80         90        100
VMKNGRVEII ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD 
       110        120        130        140        150
IKRLIGRKFD EKTMAKDIKS FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI 
       160        170        180        190        200
SAMILSKMKQ TAEAYLGKPV THAVVTVPAY FNDAQRQATK DAGTIAGLNV 
       210        220        230        240        250
IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL SIDNGVFEVL 
       260        270        280        290        300
ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA 
       310        320        330        340        350
KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV 
       360        370        380        390        400
LKDSNLKKSE IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY 
       410        420        430        440        450
GAAVQAGVLS GEEGSDNIVL LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR 
       460        470        480        490        500
KSQIFSTAVD NQNTVLIQVY EGERTLTKDN NLLGKFDLRG IPPAPRGVPQ 
       510        520        530        540        550
IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE EDIERMVKEA 
       560        570        580        590        600
EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGGK VDPEDKQAVL 
       610        620        630        640        650
DAVEDVAEWL EIHGEDASKE EFEDQRQKLD AVVHPITQKL YSEGAGDADE 
       660 
EDDDYFDDEA DEL

Length:663

Mass (Da):73,227

Last modified:December 15, 1998 - v2

Checksum:ⁱ9DB80112E6C35742

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	173	A → S in CAA45762 (PubMed:1373379).Curated	1
Sequence conflictⁱ	301 – 302	KR → NG in CAA45762 (PubMed:1373379).Curated	2
Sequence conflictⁱ	336 – 345	NMDLFKKTLK → KHGSLQEDFE in CAA45762 (PubMed:1373379).Curated	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64416 Genomic DNA Translation: CAA45762.1 CU329670 Genomic DNA Translation: CAB16585.1
PIRⁱ	S20877 T38155
NCBI Reference Sequences More...RefSeqⁱ	NP_593245.1, NM_001018642.2

Genome annotation databases

EnsemblFungiⁱ	SPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c
GeneIDⁱ	2541815
KEGGⁱ	spo:SPAC22A12.15c

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
P36604	Endoplasmic reticulum chaperone BiP	)	YEAST		682
HSP70 family		YEAS1		682
Kar2p		YEASA		682
KAR2p ATPase involved in protein import into the ER		Saccharomyces sp. 'boulardii'		682
Kar2p		YEASC		682
+1682

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64416 Genomic DNA Translation: CAA45762.1 CU329670 Genomic DNA Translation: CAB16585.1
PIRⁱ	S20877 T38155
NCBI Reference Sequences More...RefSeqⁱ	NP_593245.1, NM_001018642.2

3D structure databases

ProteinModelPortalⁱ	P36604
SMRⁱ	P36604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	278306, 4 interactors
ELMⁱ	P36604
IntActⁱ	P36604, 2 interactors
STRINGⁱ	4896.SPAC22A12.15c.1

PTM databases

iPTMnetⁱ	P36604

iPTMnetⁱ

P36604

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36604
PaxDbⁱ	P36604
PRIDEⁱ	P36604

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c
GeneIDⁱ	2541815
KEGGⁱ	spo:SPAC22A12.15c

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC22A12.15c
PomBaseⁱ	SPAC22A12.15c bip1

Phylogenomic databases

HOGENOMⁱ	HOG000228135
InParanoidⁱ	P36604
KEGG Orthology (KO) More...KOⁱ	K09490
OMAⁱ	CVGVMQK
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1VPN
PhylomeDBⁱ	P36604

Enzyme and pathway databases

Reactomeⁱ	R-SPO-3371453 Regulation of HSF1-mediated heat shock response

Reactomeⁱ

R-SPO-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P36604

PROⁱ

PR:P36604

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012 HSP70, 1 hit
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BIP_SCHPO
Accessionⁱ	P36604Primary (citable) accession number: P36604 Secondary accession number(s): O13906
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	December 15, 1998
	Last modified:	June 20, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P36604 (BIP_SCHPO)

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Endoplasmic reticulum chaperone BiP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ