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P36604

- GRP78_SCHPO

UniProt

P36604 - GRP78_SCHPO

Protein

78 kDa glucose-regulated protein homolog

Gene

bip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

    GO - Molecular functioni

    1. ATPase activity Source: PomBase
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: PomBase
    4. unfolded protein binding Source: PomBase

    GO - Biological processi

    1. 'de novo' posttranslational protein folding Source: PomBase
    2. ATP catabolic process Source: GOC
    3. cellular response to unfolded protein Source: PomBase
    4. ER-associated ubiquitin-dependent protein catabolic process Source: PomBase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188304. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BiP
    Gene namesi
    Name:bip1
    Synonyms:bip
    ORF Names:SPAC22A12.15c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC22A12.15c.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum lumen Source: PomBase
    3. Golgi apparatus Source: PomBase
    4. nuclear membrane Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 66363978 kDa glucose-regulated protein homologPRO_0000013585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Partially N-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP36604.
    PaxDbiP36604.
    PRIDEiP36604.

    Interactioni

    Protein-protein interaction databases

    BioGridi278306. 8 interactions.
    IntActiP36604. 2 interactions.
    MINTiMINT-4688922.
    STRINGi4896.SPAC22A12.15c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP36604.
    SMRiP36604. Positions 35-575.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi660 – 6634Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiPTRTIFD.
    OrthoDBiEOG728916.
    PhylomeDBiP36604.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36604-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA    50
    VMKNGRVEII ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD 100
    IKRLIGRKFD EKTMAKDIKS FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI 150
    SAMILSKMKQ TAEAYLGKPV THAVVTVPAY FNDAQRQATK DAGTIAGLNV 200
    IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL SIDNGVFEVL 250
    ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA 300
    KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV 350
    LKDSNLKKSE IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY 400
    GAAVQAGVLS GEEGSDNIVL LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR 450
    KSQIFSTAVD NQNTVLIQVY EGERTLTKDN NLLGKFDLRG IPPAPRGVPQ 500
    IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE EDIERMVKEA 550
    EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGGK VDPEDKQAVL 600
    DAVEDVAEWL EIHGEDASKE EFEDQRQKLD AVVHPITQKL YSEGAGDADE 650
    EDDDYFDDEA DEL 663
    Length:663
    Mass (Da):73,227
    Last modified:December 15, 1998 - v2
    Checksum:i9DB80112E6C35742
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731A → S in CAA45762. (PubMed:1373379)Curated
    Sequence conflicti301 – 3022KR → NG in CAA45762. (PubMed:1373379)Curated
    Sequence conflicti336 – 34510NMDLFKKTLK → KHGSLQEDFE in CAA45762. (PubMed:1373379)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64416 Genomic DNA. Translation: CAA45762.1.
    CU329670 Genomic DNA. Translation: CAB16585.1.
    PIRiS20877.
    T38155.
    RefSeqiNP_593245.1. NM_001018642.2.

    Genome annotation databases

    EnsemblFungiiSPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c.
    GeneIDi2541815.
    KEGGispo:SPAC22A12.15c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64416 Genomic DNA. Translation: CAA45762.1 .
    CU329670 Genomic DNA. Translation: CAB16585.1 .
    PIRi S20877.
    T38155.
    RefSeqi NP_593245.1. NM_001018642.2.

    3D structure databases

    ProteinModelPortali P36604.
    SMRi P36604. Positions 35-575.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278306. 8 interactions.
    IntActi P36604. 2 interactions.
    MINTi MINT-4688922.
    STRINGi 4896.SPAC22A12.15c-1.

    Proteomic databases

    MaxQBi P36604.
    PaxDbi P36604.
    PRIDEi P36604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC22A12.15c.1 ; SPAC22A12.15c.1:pep ; SPAC22A12.15c .
    GeneIDi 2541815.
    KEGGi spo:SPAC22A12.15c.

    Organism-specific databases

    PomBasei SPAC22A12.15c.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi PTRTIFD.
    OrthoDBi EOG728916.
    PhylomeDBi P36604.

    Enzyme and pathway databases

    Reactomei REACT_188304. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    NextBioi 20802903.
    PROi P36604.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe."
      Pidoux A.L., Armstrong J.
      EMBO J. 11:1583-1591(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiGRP78_SCHPO
    AccessioniPrimary (citable) accession number: P36604
    Secondary accession number(s): O13906
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3