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P36604 (GRP78_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name=BiP
Gene names
Name:bip1
Synonyms:bip
ORF Names:SPAC22A12.15c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular location

Endoplasmic reticulum lumen.

Post-translational modification

Partially N-glycosylated.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 66363978 kDa glucose-regulated protein homolog
PRO_0000013585

Regions

Motif660 – 6634Prevents secretion from ER

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1731A → S in CAA45762. Ref.1
Sequence conflict301 – 3022KR → NG in CAA45762. Ref.1
Sequence conflict336 – 34510NMDLFKKTLK → KHGSLQEDFE in CAA45762. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P36604 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 9DB80112E6C35742

FASTA66373,227
        10         20         30         40         50         60 
MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA VMKNGRVEII 

        70         80         90        100        110        120 
ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD IKRLIGRKFD EKTMAKDIKS 

       130        140        150        160        170        180 
FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI SAMILSKMKQ TAEAYLGKPV THAVVTVPAY 

       190        200        210        220        230        240 
FNDAQRQATK DAGTIAGLNV IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL 

       250        260        270        280        290        300 
SIDNGVFEVL ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA 

       310        320        330        340        350        360 
KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV LKDSNLKKSE 

       370        380        390        400        410        420 
IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY GAAVQAGVLS GEEGSDNIVL 

       430        440        450        460        470        480 
LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR KSQIFSTAVD NQNTVLIQVY EGERTLTKDN 

       490        500        510        520        530        540 
NLLGKFDLRG IPPAPRGVPQ IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE 

       550        560        570        580        590        600 
EDIERMVKEA EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGGK VDPEDKQAVL 

       610        620        630        640        650        660 
DAVEDVAEWL EIHGEDASKE EFEDQRQKLD AVVHPITQKL YSEGAGDADE EDDDYFDDEA 


DEL 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe."
Pidoux A.L., Armstrong J.
EMBO J. 11:1583-1591(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64416 Genomic DNA. Translation: CAA45762.1.
CU329670 Genomic DNA. Translation: CAB16585.1.
PIRS20877.
T38155.
RefSeqNP_593245.1. NM_001018642.2.

3D structure databases

ProteinModelPortalP36604.
SMRP36604. Positions 35-575.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278306. 8 interactions.
IntActP36604. 2 interactions.
MINTMINT-4688922.
STRING4896.SPAC22A12.15c-1.

Proteomic databases

PaxDbP36604.
PRIDEP36604.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC22A12.15c.1; SPAC22A12.15c.1:pep; SPAC22A12.15c.
GeneID2541815.
KEGGspo:SPAC22A12.15c.

Organism-specific databases

PomBaseSPAC22A12.15c.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228135.
KOK09490.
OMACWIALLF.
OrthoDBEOG728916.
PhylomeDBP36604.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802903.
PROP36604.

Entry information

Entry nameGRP78_SCHPO
AccessionPrimary (citable) accession number: P36604
Secondary accession number(s): O13906
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names