UniProtKB - P36603 (RIR2_SCHPO)
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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
suc22
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activityi
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation
Cofactori
Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity
: DNA replication Pathwayi
This protein is involved in the pathway DNA replication, which is part of Genetic information processing.View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 135 | Iron 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Iron 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Iron 2By similarity | 1 | |
Metal bindingi | 169 | Iron 1PROSITE-ProRule annotation | 1 | |
Active sitei | 173 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 229 | Iron 2By similarity | 1 | |
Metal bindingi | 263 | Iron 2By similarity | 1 | |
Metal bindingi | 266 | Iron 2By similarity | 1 |
GO - Molecular functioni
- CDP reductase activity Source: PomBase
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- CDP metabolic process Source: PomBase
- dCDP biosynthetic process Source: PomBase
- DNA replication Source: UniProtKB-UniPathway
- purine deoxyribonucleoside triphosphate biosynthetic process Source: PomBase
- purine nucleoside metabolic process Source: PomBase
- pyrimidine deoxyribonucleoside triphosphate biosynthetic process Source: PomBase
- pyrimidine nucleoside metabolic process Source: PomBase
Keywordsi
Molecular function | Oxidoreductase |
Biological process | DNA replication |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-SPO-499943. Interconversion of nucleotide di- and triphosphates. |
UniPathwayi | UPA00326. |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)Alternative name(s): Ribonucleotide reductase small subunit |
Gene namesi | Name:suc22 ORF Names:SPBC25D12.04 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC25D12.04. |
PomBasei | SPBC25D12.04. suc22. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190463 | 1 – 391 | Ribonucleoside-diphosphate reductase small chainAdd BLAST | 391 |
Proteomic databases
MaxQBi | P36603. |
PaxDbi | P36603. |
PRIDEi | P36603. |
PTM databases
iPTMneti | P36603. |
SwissPalmi | P36603. |
Interactioni
Subunit structurei
Heterodimer of a large and a small subunit.
Protein-protein interaction databases
BioGridi | 276910. 8 interactors. |
STRINGi | 4896.SPBC25D12.04.1. |
Structurei
3D structure databases
ProteinModelPortali | P36603. |
SMRi | P36603. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ribonucleoside diphosphate reductase small chain family.Curated
Phylogenomic databases
HOGENOMi | HOG000255975. |
InParanoidi | P36603. |
KOi | K10808. |
OMAi | FYVGFVQ. |
OrthoDBi | EOG092C3G06. |
PhylomeDBi | P36603. |
Family and domain databases
CDDi | cd01049. RNRR2. 1 hit. |
Gene3Di | 1.10.620.20. 1 hit. |
InterProi | View protein in InterPro IPR009078. Ferritin-like_SF. IPR012348. RNR-like. IPR033909. RNR_small. IPR030475. RNR_small_AS. IPR000358. RNR_small_fam. |
PANTHERi | PTHR23409. PTHR23409. 1 hit. |
Pfami | View protein in Pfam PF00268. Ribonuc_red_sm. 1 hit. |
SUPFAMi | SSF47240. SSF47240. 1 hit. |
PROSITEi | View protein in PROSITE PS00368. RIBORED_SMALL. 1 hit. |
i Sequence
Sequence statusi: Complete.
P36603-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLEHLEEFS YPKEHGEEVE YDSEQGVRKI YVKSIKETFN FDNVSEEEKQ
60 70 80 90 100
EGGDYYLGKK EDELDEVVLR PNPHRFVLFP IKYHEIWQFY KKAEASFWTA
110 120 130 140 150
EEIDLSKDLV DWDNKLNADE RYFISTVLAY FAASDGIVNE NLLERFSSEV
160 170 180 190 200
QIPEARCVYG FQIMIENIHS ETYSLLLDTY IREPKEKQRH FDAILTMGSI
210 220 230 240 250
KAKAKWALRW INDEDSTYAI RLVAFAAVEG IFFSGSFASI FWLKKRGLMP
260 270 280 290 300
GLTFSNELIC RDEGLHTDFA CLMFSHLKHR PGRKVVEAII VEAVDIEKEY
310 320 330 340 350
FTDALPVSLL GMNKDLMCQY IEFVADRLLV ALGNDKYYNV TNPFDFMENI
360 370 380 390
SLAGKTNFFE KKVSDYQIAG VMSGTKRAEK DDHTFTIDED F
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 285 – 288 | VVEA → LLKP in CAA46231 (PubMed:8479429).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65115 Genomic DNA. Translation: CAA46231.1. CU329671 Genomic DNA. Translation: CAA20100.1. |
PIRi | S34808. T39992. |
RefSeqi | NP_596546.1. NM_001022467.2. |
Genome annotation databases
EnsemblFungii | SPBC25D12.04.1; SPBC25D12.04.1:pep; SPBC25D12.04. |
GeneIDi | 2540381. |
KEGGi | spo:SPBC25D12.04. |
Similar proteinsi
Entry informationi
Entry namei | RIR2_SCHPO | |
Accessioni | P36603Primary (citable) accession number: P36603 Secondary accession number(s): O74355 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |