suc22

Functionⁱ

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityⁱ

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H₂O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactorⁱ

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayⁱ: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	135	Iron 1PROSITE-ProRule annotation	1
Metal bindingⁱ	166	Iron 1PROSITE-ProRule annotation	1
Metal bindingⁱ	166	Iron 2By similarity	1
Metal bindingⁱ	169	Iron 1PROSITE-ProRule annotation	1
Active siteⁱ	173	PROSITE-ProRule annotation	1
Metal bindingⁱ	229	Iron 2By similarity	1
Metal bindingⁱ	263	Iron 2By similarity	1
Metal bindingⁱ	266	Iron 2By similarity	1

GO - Molecular functionⁱ

CDP reductase activity
Source: PomBase
Inferred from direct assayⁱ
- 16317005
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

CDP metabolic process
Source: PomBase
Inferred from direct assayⁱ
- 16317005
dCDP biosynthetic process
Source: PomBase
Inferred from direct assayⁱ
- 16317005
DNA replication Source: UniProtKB-UniPathway
purine deoxyribonucleoside triphosphate biosynthetic process Source: PomBase
purine nucleoside metabolic process Source: PomBase
pyrimidine deoxyribonucleoside triphosphate biosynthetic process Source: PomBase
pyrimidine nucleoside metabolic process Source: PomBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	DNA replication
Ligand	Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-SPO-499943. Interconversion of nucleotide di- and triphosphates.
UniPathwayⁱ	UPA00326.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1) Alternative name(s): Ribonucleotide reductase small subunit
Gene namesⁱ	Name:suc22 ORF Names:SPBC25D12.04
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome II

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC25D12.04.
PomBaseⁱ	SPBC25D12.04. suc22.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000190463	1 – 391	Ribonucleoside-diphosphate reductase small chainAdd BLAST		391

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36603.
PaxDbⁱ	P36603.
PRIDEⁱ	P36603.

PTM databases

iPTMnetⁱ	P36603.
SwissPalmⁱ	P36603.

Interactionⁱ

Subunit structureⁱ

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

BioGridⁱ	276910. 8 interactors.
STRINGⁱ	4896.SPBC25D12.04.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P36603.
SMRⁱ	P36603.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ribonucleoside diphosphate reductase small chain family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000255975.
InParanoidⁱ	P36603.
KEGG Orthology (KO) More...KOⁱ	K10808.
OMAⁱ	FYVGFVQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3G06.
PhylomeDBⁱ	P36603.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01049. RNRR2. 1 hit.
Gene3Dⁱ	1.10.620.20. 1 hit.
InterProⁱ	View protein in InterPro IPR009078. Ferritin-like_SF. IPR012348. RNR-like. IPR033909. RNR_small. IPR030475. RNR_small_AS. IPR000358. RNR_small_fam.
PANTHERⁱ	PTHR23409. PTHR23409. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00268. Ribonuc_red_sm. 1 hit.
SUPFAMⁱ	SSF47240. SSF47240. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00368. RIBORED_SMALL. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P36603-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLEHLEEFS YPKEHGEEVE YDSEQGVRKI YVKSIKETFN FDNVSEEEKQ 
        60         70         80         90        100
EGGDYYLGKK EDELDEVVLR PNPHRFVLFP IKYHEIWQFY KKAEASFWTA 
       110        120        130        140        150
EEIDLSKDLV DWDNKLNADE RYFISTVLAY FAASDGIVNE NLLERFSSEV 
       160        170        180        190        200
QIPEARCVYG FQIMIENIHS ETYSLLLDTY IREPKEKQRH FDAILTMGSI 
       210        220        230        240        250
KAKAKWALRW INDEDSTYAI RLVAFAAVEG IFFSGSFASI FWLKKRGLMP 
       260        270        280        290        300
GLTFSNELIC RDEGLHTDFA CLMFSHLKHR PGRKVVEAII VEAVDIEKEY 
       310        320        330        340        350
FTDALPVSLL GMNKDLMCQY IEFVADRLLV ALGNDKYYNV TNPFDFMENI 
       360        370        380        390 
SLAGKTNFFE KKVSDYQIAG VMSGTKRAEK DDHTFTIDED F

Length:391

Mass (Da):45,405

Last modified:December 1, 2000 - v2

Checksum:ⁱ740ECDBECC8D0170

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	285 – 288	VVEA → LLKP in CAA46231 (PubMed:8479429).Curated		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65115 Genomic DNA. Translation: CAA46231.1. CU329671 Genomic DNA. Translation: CAA20100.1.
PIRⁱ	S34808. T39992.
NCBI Reference Sequences More...RefSeqⁱ	NP_596546.1. NM_001022467.2.

Genome annotation databases

EnsemblFungiⁱ	SPBC25D12.04.1; SPBC25D12.04.1:pep; SPBC25D12.04.
GeneIDⁱ	2540381.
KEGGⁱ	spo:SPBC25D12.04.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P36603	A0A1L0D092 A0A1D2MDP1 A7TFK0 A0A1B6E767 A0A1B6INQ1 UPI00062610DE UPI00062672A8 UPI00062550F9 UPI0006263362 UPI000625AA8C +175	[Candida] intermedia Orchesella cincta (Springtail) Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) Clastoptera arizonana (Arizona spittle bug) Homalodisca liturata Athalia rosae (Turnip sawfly) Chlamydomonas reinhardtii (Chlamydomonas smithii) Nannochloropsis gaditana Nannochloropsis gaditana (strain CCMP526) (Green microalga) Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode) And more	391	UniRef50_P36603	Cluster: Ribonucleoside-diphosphate reductase small chain	186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65115 Genomic DNA. Translation: CAA46231.1. CU329671 Genomic DNA. Translation: CAA20100.1.
PIRⁱ	S34808. T39992.
NCBI Reference Sequences More...RefSeqⁱ	NP_596546.1. NM_001022467.2.

3D structure databases

ProteinModelPortalⁱ	P36603.
SMRⁱ	P36603.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	276910. 8 interactors.
STRINGⁱ	4896.SPBC25D12.04.1.

PTM databases

iPTMnetⁱ	P36603.
SwissPalmⁱ	P36603.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36603.
PaxDbⁱ	P36603.
PRIDEⁱ	P36603.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPBC25D12.04.1; SPBC25D12.04.1:pep; SPBC25D12.04.
GeneIDⁱ	2540381.
KEGGⁱ	spo:SPBC25D12.04.

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC25D12.04.
PomBaseⁱ	SPBC25D12.04. suc22.

Phylogenomic databases

HOGENOMⁱ	HOG000255975.
InParanoidⁱ	P36603.
KEGG Orthology (KO) More...KOⁱ	K10808.
OMAⁱ	FYVGFVQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3G06.
PhylomeDBⁱ	P36603.

Enzyme and pathway databases

UniPathwayⁱ	UPA00326.
Reactomeⁱ	R-SPO-499943. Interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P36603.

PROⁱ

PR:P36603.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01049. RNRR2. 1 hit.
Gene3Dⁱ	1.10.620.20. 1 hit.
InterProⁱ	View protein in InterPro IPR009078. Ferritin-like_SF. IPR012348. RNR-like. IPR033909. RNR_small. IPR030475. RNR_small_AS. IPR000358. RNR_small_fam.
PANTHERⁱ	PTHR23409. PTHR23409. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00268. Ribonuc_red_sm. 1 hit.
SUPFAMⁱ	SSF47240. SSF47240. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00368. RIBORED_SMALL. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIR2_SCHPO
Accessionⁱ	P36603Primary (citable) accession number: P36603 Secondary accession number(s): O74355
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	December 1, 2000
	Last modified:	February 28, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P36603 (RIR2_SCHPO)

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Ribonucleoside-diphosphate reductase small chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: DNA replication

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: DNA replication

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ