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Protein

DNA repair protein rhp51

Gene

rhp51

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 156ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB
  • double-stranded DNA binding Source: UniProtKB
  • four-way junction DNA binding Source: GO_Central
  • identical protein binding Source: IntAct
  • protein-DNA loading ATPase activity Source: PomBase
  • recombinase activity Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB
  • Swi5-Sfr1 complex binding Source: PomBase

GO - Biological processi

  • chromatin silencing at centromere Source: PomBase
  • chromosome organization involved in meiotic cell cycle Source: GO_Central
  • DNA recombinase assembly Source: GO_Central
  • double-strand break repair involved in meiotic recombination Source: PomBase
  • double-strand break repair via homologous recombination Source: PomBase
  • interstrand cross-link repair Source: PomBase
  • mating type switching Source: PomBase
  • mitotic recombination Source: PomBase
  • mitotic recombination-dependent replication fork processing Source: PomBase
  • negative regulation of DNA strand resection involved in replication fork processing Source: PomBase
  • protein homooligomerization Source: UniProtKB
  • regulation of DNA recombination at centromere Source: PomBase
  • response to ionizing radiation Source: GO_Central
  • strand invasion Source: PomBase
  • telomere maintenance Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein rhp51
Alternative name(s):
RAD51 homolog
Gene namesi
Name:rhp51
Synonyms:rad51
ORF Names:SPAC644.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC644.14c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229241 – 365DNA repair protein rhp51Add BLAST365

Proteomic databases

MaxQBiP36601
PaxDbiP36601
PRIDEiP36601

Interactioni

Subunit structurei

Interacts with rad22, rad54, rdh54, rhp54, rti1, swi2 and swi5. Forms homooiligomers.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-29235N
IntActiP36601, 10 interactors
MINTiP36601
STRINGi4896.SPAC644.14c.1

Structurei

3D structure databases

ProteinModelPortaliP36601
SMRiP36601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000227426
InParanoidiP36601
KOiK04482
OrthoDBiEOG092C3DRU
PhylomeDBiP36601

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

P36601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTEVEMQV SAADTNNNEN GQAQSNYEYD VNVQDEEDEA AAGPMPLQML
60 70 80 90 100
EGNGITASDI KKIHEAGYYT VESIAYTPKR QLLLIKGISE AKADKLLGEA
110 120 130 140 150
SKLVPMGFTT ATEYHIRRSE LITITTGSKQ LDTLLQGGVE TGSITELFGE
160 170 180 190 200
FRTGKSQICH TLAVTCQLPI DMGGGEGKCL YIDTEGTFRP VRLLAVADRY
210 220 230 240 250
GLNGEEVLDN VAYARAYNAD HQLELLQQAA NMMSESRFSL LVVDSCTALY
260 270 280 290 300
RTDFSGRGEL SARQMHLARF MRTLQRLADE FGIAVVITNQ VVAQVDGISF
310 320 330 340 350
NPDPKKPIGG NILAHSSTTR LSLRKGRGEQ RICKIYDSPC LPESEAIFAI
360
NSDGVGDPKE IIAPV
Length:365
Mass (Da):39,823
Last modified:June 1, 1994 - v1
Checksum:i9F26EB9FA4F3C2BA
GO

Sequence cautioni

The sequence CAA80878 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15T → M (PubMed:8358431).Curated1
Sequence conflicti15T → M (PubMed:11859360).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13805 Genomic DNA Translation: BAA02963.1
Z22691 Genomic DNA Translation: CAA80399.1
Z24756 Genomic DNA Translation: CAA80879.1
Z24756 Genomic DNA Translation: CAA80878.1 Different initiation.
CU329670 Genomic DNA Translation: CAB90141.1
PIRiS42107
RefSeqiNP_593882.1, NM_001019312.2

Genome annotation databases

GeneIDi2543580
KEGGispo:SPAC644.14c

Similar proteinsi

Entry informationi

Entry nameiRAD51_SCHPO
AccessioniPrimary (citable) accession number: P36601
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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