Reviewed, UniProtKB/Swiss-Prot P36599 (PDE1_SCHPO)

Names and origin

Protein names

Recommended name:
    3',5'-cyclic-nucleotide phosphodiesterase
      Short name=PDEase
    EC=3.1.4.17

Gene names

Name:	cgs2
Synonyms:	pde1
ORF Names:	SPCC285.09c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Sequence similarities	Belongs to the cAMP phosphodiesterase class-II family.

Ontologies

Keywords
Ligand	cAMP
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP catabolic process Inferred from electronic annotation. Source: InterPro cAMP-mediated signaling Inferred from mutant phenotype. Source: GeneDB_SPombe cellular response to nitrogen starvation Inferred from mutant phenotype. Source: GeneDB_SPombe negative regulation of adenylate cyclase activity Traceable author statement. Source: GeneDB_SPombe positive regulation of gene-specific transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: GeneDB_SPombe regulation of conjugation with cellular fusion Inferred from mutant phenotype. Source: GeneDB_SPombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from genetic interaction. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	3',5'-cyclic-nucleotide phosphodiesterase		PRO_0000206790

Sequences

	Sequence		Length	Mass (Da)
	P36599-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: E3EAC5F7F191FA90	FASTA	346	38,650
	10 20 30 40 50 60 MHAALEIKEA EFQTDQVVGL VENSFTLYSL GQNGGPLESC CSSHLISDGA FQEIISLDGG 70 80 90 100 110 120 SHLSALVELI QSKHLSVDSW SSITKYDNYT VENESYAKAW HLSEQRIKTF LITHCHLDHI 130 140 150 160 170 180 YGAVINSAMF GPQNPRTIVG LNYVIDTLKK HVFNNLLWPS LDKAGFINFQ VVEPSMYTSL 190 200 210 220 230 240 TTTLSILPFP VNHGSSFGQE LKSSAFLFRN NLSDRYFLAF GDVEPDMVAS EPLNIHIWRA 250 260 270 280 290 300 CSSLIAQRKL SHILIECSTP DIPDTLLFGH FCPRHLVNEL CILQSLVQSY GVIMPTLTCL 310 320 330 340 LTHLKSHPLQ SANPADVILE QLESLSSKSS LSVTFKILQR GQFYKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis." Devoti J., Seydoux G., Beach D., McLeod M. EMBO J. 10:3759-3768(1991) [PubMed: 1657594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S64907 Genomic DNA. Translation: AAB20315.1. CU329672 Genomic DNA. Translation: CAA20848.1.
PIR	S22442.
RefSeq	NP_588337.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P36599.
Genome annotation databases
GeneID	2539207.
GenomeReviews	Gene locus cgs2 in contig CU329672_GR.
KEGG	spo:SPCC285.09c.
NMPDR	fig|4896.1.peg.675.
Organism-specific databases
GeneDB_Spombe	SPCC285.09c.
Phylogenomic databases
OMA	YFGDTGA.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000258-MON.
BRENDA	3.1.4.17. 653.
Gene expression databases
ArrayExpress	P36599.
Family and domain databases
InterPro	IPR000396. Pdiesterase2. [Graphical view]
Pfam	PF02112. PDEase_II. 1 hit. [Graphical view]
PIRSF	PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTS	PR00388. PDIESTERASE2.
ProDom	PD010003. Pdiesterase2_lac. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00607. PDEASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDE1_SCHPO

Accession

Primary (citable) accession number: P36599

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)