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Protein

3',5'-cyclic-nucleotide phosphodiesterase

Gene

cgs2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: PomBase
  • 3',5'-cyclic-GMP phosphodiesterase activity Source: PomBase

GO - Biological processi

  • cAMP catabolic process Source: PomBase
  • cellular response to glucose stimulus Source: PomBase
  • cGMP catabolic process Source: GO_Central
  • negative regulation of cAMP biosynthetic process Source: PomBase
  • negative regulation of cAMP-dependent protein kinase activity Source: PomBase
  • negative regulation of glucose mediated signaling pathway Source: PomBase
  • negative regulation of meiotic cell cycle Source: PomBase
  • regulation of cAMP-mediated signaling Source: PomBase
  • regulation of signal transduction involved in conjugation with cellular fusion Source: PomBase

Keywordsi

Molecular functionHydrolase
LigandcAMP

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic-nucleotide phosphodiesterase (EC:3.1.4.17)
Short name:
PDEase
Gene namesi
Name:cgs2
Synonyms:pde1
ORF Names:SPCC285.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC285.09c.
PomBaseiSPCC285.09c. cgs2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067901 – 3463',5'-cyclic-nucleotide phosphodiesteraseAdd BLAST346

Proteomic databases

MaxQBiP36599.
PRIDEiP36599.

Interactioni

Protein-protein interaction databases

BioGridi275777. 43 interactors.
MINTiMINT-4688853.
STRINGi4896.SPCC285.09c.1.

Structurei

3D structure databases

ProteinModelPortaliP36599.
SMRiP36599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP36599.
KOiK01120.
OrthoDBiEOG092C21MM.
PhylomeDBiP36599.

Family and domain databases

CDDicd07735. class_II_PDE_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
InterProiView protein in InterPro
IPR024225. cAMP-PdiesteraseII_CS.
IPR001279. Metallo-B-lactamas.
IPR000396. Pdiesterase2.
PANTHERiPTHR28283. PTHR28283. 1 hit.
PfamiView protein in Pfam
PF02112. PDEase_II. 1 hit.
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiView protein in PROSITE
PS00607. PDEASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P36599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAALEIKEA EFQTDQVVGL VENSFTLYSL GQNGGPLESC CSSHLISDGA
60 70 80 90 100
FQEIISLDGG SHLSALVELI QSKHLSVDSW SSITKYDNYT VENESYAKAW
110 120 130 140 150
HLSEQRIKTF LITHCHLDHI YGAVINSAMF GPQNPRTIVG LNYVIDTLKK
160 170 180 190 200
HVFNNLLWPS LDKAGFINFQ VVEPSMYTSL TTTLSILPFP VNHGSSFGQE
210 220 230 240 250
LKSSAFLFRN NLSDRYFLAF GDVEPDMVAS EPLNIHIWRA CSSLIAQRKL
260 270 280 290 300
SHILIECSTP DIPDTLLFGH FCPRHLVNEL CILQSLVQSY GVIMPTLTCL
310 320 330 340
LTHLKSHPLQ SANPADVILE QLESLSSKSS LSVTFKILQR GQFYKF
Length:346
Mass (Da):38,650
Last modified:June 1, 1994 - v1
Checksum:iE3EAC5F7F191FA90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64907 Genomic DNA. Translation: AAB20315.1.
CU329672 Genomic DNA. Translation: CAA20848.1.
PIRiS22442.
RefSeqiNP_588337.1. NM_001023328.2.

Genome annotation databases

EnsemblFungiiSPCC285.09c.1; SPCC285.09c.1:pep; SPCC285.09c.
GeneIDi2539207.
KEGGispo:SPCC285.09c.

Similar proteinsi

Entry informationi

Entry nameiPDE1_SCHPO
AccessioniPrimary (citable) accession number: P36599
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families