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P36599

- PDE1_SCHPO

UniProt

P36599 - PDE1_SCHPO

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Protein

3',5'-cyclic-nucleotide phosphodiesterase

Gene
cgs2, pde1, SPCC285.09c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: PomBase

GO - Biological processi

  1. cAMP catabolic process Source: PomBase
  2. cAMP-mediated signaling Source: PomBase
  3. cellular response to glucose stimulus Source: PomBase
  4. cellular response to nitrogen starvation Source: PomBase
  5. negative regulation of adenylate cyclase activity Source: PomBase
  6. negative regulation of cAMP biosynthetic process Source: PomBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  8. regulation of conjugation with cellular fusion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic-nucleotide phosphodiesterase (EC:3.1.4.17)
Short name:
PDEase
Gene namesi
Name:cgs2
Synonyms:pde1
ORF Names:SPCC285.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC285.09c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3463463',5'-cyclic-nucleotide phosphodiesterasePRO_0000206790Add
BLAST

Proteomic databases

MaxQBiP36599.

Interactioni

Protein-protein interaction databases

BioGridi275777. 44 interactions.
MINTiMINT-4688853.
STRINGi4896.SPCC285.09c-1.

Structurei

3D structure databases

ProteinModelPortaliP36599.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5212.
KOiK01120.
OMAiFESANTM.
OrthoDBiEOG7X6MB3.
PhylomeDBiP36599.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view]
PfamiPF02112. PDEase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSiPR00388. PDIESTERASE2.
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00607. PDEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36599-1 [UniParc]FASTAAdd to Basket

« Hide

MHAALEIKEA EFQTDQVVGL VENSFTLYSL GQNGGPLESC CSSHLISDGA    50
FQEIISLDGG SHLSALVELI QSKHLSVDSW SSITKYDNYT VENESYAKAW 100
HLSEQRIKTF LITHCHLDHI YGAVINSAMF GPQNPRTIVG LNYVIDTLKK 150
HVFNNLLWPS LDKAGFINFQ VVEPSMYTSL TTTLSILPFP VNHGSSFGQE 200
LKSSAFLFRN NLSDRYFLAF GDVEPDMVAS EPLNIHIWRA CSSLIAQRKL 250
SHILIECSTP DIPDTLLFGH FCPRHLVNEL CILQSLVQSY GVIMPTLTCL 300
LTHLKSHPLQ SANPADVILE QLESLSSKSS LSVTFKILQR GQFYKF 346
Length:346
Mass (Da):38,650
Last modified:June 1, 1994 - v1
Checksum:iE3EAC5F7F191FA90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S64907 Genomic DNA. Translation: AAB20315.1.
CU329672 Genomic DNA. Translation: CAA20848.1.
PIRiS22442.
RefSeqiNP_588337.1. NM_001023328.2.

Genome annotation databases

EnsemblFungiiSPCC285.09c.1; SPCC285.09c.1:pep; SPCC285.09c.
GeneIDi2539207.
KEGGispo:SPCC285.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S64907 Genomic DNA. Translation: AAB20315.1 .
CU329672 Genomic DNA. Translation: CAA20848.1 .
PIRi S22442.
RefSeqi NP_588337.1. NM_001023328.2.

3D structure databases

ProteinModelPortali P36599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275777. 44 interactions.
MINTi MINT-4688853.
STRINGi 4896.SPCC285.09c-1.

Proteomic databases

MaxQBi P36599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC285.09c.1 ; SPCC285.09c.1:pep ; SPCC285.09c .
GeneIDi 2539207.
KEGGi spo:SPCC285.09c.

Organism-specific databases

PomBasei SPCC285.09c.

Phylogenomic databases

eggNOGi COG5212.
KOi K01120.
OMAi FESANTM.
OrthoDBi EOG7X6MB3.
PhylomeDBi P36599.

Miscellaneous databases

NextBioi 20800377.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR024225. cAMP-PdiesteraseII_CS.
IPR000396. Pdiesterase2.
[Graphical view ]
Pfami PF02112. PDEase_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF000962. Cyc_nuc_PDEase. 1 hit.
PRINTSi PR00388. PDIESTERASE2.
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00607. PDEASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis."
    Devoti J., Seydoux G., Beach D., McLeod M.
    EMBO J. 10:3759-3768(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPDE1_SCHPO
AccessioniPrimary (citable) accession number: P36599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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