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P36599

- PDE1_SCHPO

UniProt

P36599 - PDE1_SCHPO

Protein

3',5'-cyclic-nucleotide phosphodiesterase

Gene

cgs2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: PomBase

    GO - Biological processi

    1. cAMP catabolic process Source: PomBase
    2. cAMP-mediated signaling Source: PomBase
    3. cellular response to glucose stimulus Source: PomBase
    4. cellular response to nitrogen starvation Source: PomBase
    5. negative regulation of adenylate cyclase activity Source: PomBase
    6. negative regulation of cAMP biosynthetic process Source: PomBase
    7. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
    8. regulation of conjugation with cellular fusion Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic-nucleotide phosphodiesterase (EC:3.1.4.17)
    Short name:
    PDEase
    Gene namesi
    Name:cgs2
    Synonyms:pde1
    ORF Names:SPCC285.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC285.09c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3463463',5'-cyclic-nucleotide phosphodiesterasePRO_0000206790Add
    BLAST

    Proteomic databases

    MaxQBiP36599.

    Interactioni

    Protein-protein interaction databases

    BioGridi275777. 44 interactions.
    MINTiMINT-4688853.
    STRINGi4896.SPCC285.09c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP36599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5212.
    KOiK01120.
    OMAiFESANTM.
    OrthoDBiEOG7X6MB3.
    PhylomeDBiP36599.

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR024225. cAMP-PdiesteraseII_CS.
    IPR000396. Pdiesterase2.
    [Graphical view]
    PfamiPF02112. PDEase_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000962. Cyc_nuc_PDEase. 1 hit.
    PRINTSiPR00388. PDIESTERASE2.
    SUPFAMiSSF56281. SSF56281. 1 hit.
    PROSITEiPS00607. PDEASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36599-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHAALEIKEA EFQTDQVVGL VENSFTLYSL GQNGGPLESC CSSHLISDGA    50
    FQEIISLDGG SHLSALVELI QSKHLSVDSW SSITKYDNYT VENESYAKAW 100
    HLSEQRIKTF LITHCHLDHI YGAVINSAMF GPQNPRTIVG LNYVIDTLKK 150
    HVFNNLLWPS LDKAGFINFQ VVEPSMYTSL TTTLSILPFP VNHGSSFGQE 200
    LKSSAFLFRN NLSDRYFLAF GDVEPDMVAS EPLNIHIWRA CSSLIAQRKL 250
    SHILIECSTP DIPDTLLFGH FCPRHLVNEL CILQSLVQSY GVIMPTLTCL 300
    LTHLKSHPLQ SANPADVILE QLESLSSKSS LSVTFKILQR GQFYKF 346
    Length:346
    Mass (Da):38,650
    Last modified:June 1, 1994 - v1
    Checksum:iE3EAC5F7F191FA90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64907 Genomic DNA. Translation: AAB20315.1.
    CU329672 Genomic DNA. Translation: CAA20848.1.
    PIRiS22442.
    RefSeqiNP_588337.1. NM_001023328.2.

    Genome annotation databases

    EnsemblFungiiSPCC285.09c.1; SPCC285.09c.1:pep; SPCC285.09c.
    GeneIDi2539207.
    KEGGispo:SPCC285.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64907 Genomic DNA. Translation: AAB20315.1 .
    CU329672 Genomic DNA. Translation: CAA20848.1 .
    PIRi S22442.
    RefSeqi NP_588337.1. NM_001023328.2.

    3D structure databases

    ProteinModelPortali P36599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275777. 44 interactions.
    MINTi MINT-4688853.
    STRINGi 4896.SPCC285.09c-1.

    Proteomic databases

    MaxQBi P36599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC285.09c.1 ; SPCC285.09c.1:pep ; SPCC285.09c .
    GeneIDi 2539207.
    KEGGi spo:SPCC285.09c.

    Organism-specific databases

    PomBasei SPCC285.09c.

    Phylogenomic databases

    eggNOGi COG5212.
    KOi K01120.
    OMAi FESANTM.
    OrthoDBi EOG7X6MB3.
    PhylomeDBi P36599.

    Miscellaneous databases

    NextBioi 20800377.

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR024225. cAMP-PdiesteraseII_CS.
    IPR000396. Pdiesterase2.
    [Graphical view ]
    Pfami PF02112. PDEase_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000962. Cyc_nuc_PDEase. 1 hit.
    PRINTSi PR00388. PDIESTERASE2.
    SUPFAMi SSF56281. SSF56281. 1 hit.
    PROSITEi PS00607. PDEASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis."
      Devoti J., Seydoux G., Beach D., McLeod M.
      EMBO J. 10:3759-3768(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPDE1_SCHPO
    AccessioniPrimary (citable) accession number: P36599
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3