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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC2

Gene

rpb6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, elongation Source: PomBase
  • transcription by RNA polymerase I Source: PomBase
  • transcription by RNA polymerase II Source: PomBase
  • transcription by RNA polymerase III Source: PomBase

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-SPO-113418 Formation of the Early Elongation Complex
R-SPO-5578749 Transcriptional regulation by small RNAs
R-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SPO-72086 mRNA Capping
R-SPO-72165 mRNA Splicing - Minor Pathway
R-SPO-73762 RNA Polymerase I Transcription Initiation
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-SPO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Short name:
RNA polymerases I, II, and III subunit ABC2
Alternative name(s):
DNA-directed RNA polymerases I, II, and III 15 kDa polypeptide
RPC16
Gene namesi
Name:rpb6
Synonyms:rpo15
ORF Names:SPCC1020.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.04c
PomBaseiSPCC1020.04c rpb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001337961 – 142DNA-directed RNA polymerases I, II, and III subunit RPABC2Add BLAST142

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36595
PaxDbiP36595
PRIDEiP36595

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 14, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi275655, 12 interactors
IntActiP36595, 1 interactor
STRINGi4896.SPCC1020.04c.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65F/R1-142[»]
5U0Selectron microscopy7.80f1-142[»]
DisProtiDP00980
ProteinModelPortaliP36595
SMRiP36595
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36595

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000225272
InParanoidiP36595
KOiK03014
OrthoDBiEOG092C5A9A
PhylomeDBiP36595

Family and domain databases

Gene3Di3.90.940.10, 1 hit
HAMAPiMF_00192 RNApol_arch_K, 1 hit
InterProiView protein in InterPro
IPR020708 DNA-dir_RNA_polK_14-18kDa_CS
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR028363 RPB6
IPR036161 RPB6/omega_like_sf
IPR006111 RpoK/Rpb6
PfamiView protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit
PIRSFiPIRSF500154 RPB6, 1 hit
PIRSF000778 RpoK/RPB6, 1 hit
SMARTiView protein in SMART
SM01409 RNA_pol_Rpb6, 1 hit
SUPFAMiSSF63562 SSF63562, 1 hit
PROSITEiView protein in PROSITE
PS01111 RNA_POL_K_14KD, 1 hit

Sequencei

Sequence statusi: Complete.

P36595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYEEDEAF GMDGAVMEEE VDELEMIDEN GQSQQGVSHP GEPSTTVITE
60 70 80 90 100
DVASSKTAQS GKAVAKEDRT TTPYMTKYER ARILGTRALQ ISMNAPVLVD
110 120 130 140
LEGETDPLQI AMKELAQKKI PLLVRRYLPD GSYEDWSVAE LI
Length:142
Mass (Da):15,729
Last modified:June 1, 1994 - v1
Checksum:iFDC4E7AD5B495D79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00597 Genomic DNA Translation: AAA52084.1
L25592 Genomic DNA Translation: AAB04116.1
CU329672 Genomic DNA Translation: CAA18992.1
PIRiT40837
RefSeqiNP_587956.1, NM_001022947.2

Genome annotation databases

EnsemblFungiiSPCC1020.04c.1; SPCC1020.04c.1:pep; SPCC1020.04c
GeneIDi2539083
KEGGispo:SPCC1020.04c

Similar proteinsi

Entry informationi

Entry nameiRPAB2_SCHPO
AccessioniPrimary (citable) accession number: P36595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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