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Protein

DNA repair and recombination protein rad22

Gene

rad22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.

GO - Molecular functioni

  • damaged DNA binding Source: PomBase
  • DNA end binding Source: PomBase
  • double-stranded DNA binding Source: PomBase
  • single-stranded DNA binding Source: PomBase

GO - Biological processi

  • DNA recombinase assembly Source: PomBase
  • double-strand break repair via homologous recombination Source: PomBase
  • double-strand break repair via single-strand annealing Source: InterPro
  • mating type switching Source: PomBase
  • mitotic recombination Source: PomBase
  • mitotic recombination-dependent replication fork processing Source: PomBase
  • negative regulation of DNA binding Source: PomBase
  • negative regulation of DNA strand resection involved in replication fork processing Source: PomBase
  • negative regulation of meiotic joint molecule formation Source: PomBase
  • telomere maintenance Source: PomBase
  • telomere maintenance via recombination Source: PomBase

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

ReactomeiR-SPO-3108214 SUMOylation of DNA damage response and repair proteins
R-SPO-5685938 HDR through Single Strand Annealing (SSA)

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein rad22
Gene namesi
Name:rad22
ORF Names:SPAC30D11.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC30D11.10
PomBaseiSPAC30D11.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738911 – 469DNA repair and recombination protein rad22Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296Phosphoserine1 Publication1
Modified residuei319Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36592
PaxDbiP36592
PRIDEiP36592

PTM databases

iPTMnetiP36592

Interactioni

Subunit structurei

Interacts with rhp51.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi279519, 55 interactors
IntActiP36592, 5 interactors
MINTiP36592
STRINGi4896.SPAC30D11.10.1

Structurei

3D structure databases

ProteinModelPortaliP36592
SMRiP36592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAD52 family.Curated

Phylogenomic databases

InParanoidiP36592
KOiK10873
OrthoDBiEOG092C4C2A
PhylomeDBiP36592

Family and domain databases

InterProiView protein in InterPro
IPR004585 DNA_recomb/repair_Rad52
IPR007232 Rad52_Rad59_Rad22
PANTHERiPTHR12132 PTHR12132, 1 hit
PfamiView protein in Pfam
PF04098 Rad52_Rad22, 1 hit
TIGRFAMsiTIGR00607 rad52, 1 hit

Sequencei

Sequence statusi: Complete.

P36592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEQKQHVA SEDQGHFNTA YSHEEFNFLQ SSLTRKLGPE YVSRRSGPGG
60 70 80 90 100
FSVSYIESWK AIELANEIFG FNGWSSSIRS INVDFMDENK ENGRISLGLS
110 120 130 140 150
VIVRVTIKDG AYHEDIGYGS IDNCRGKASA FEKCKKEGTT DALKRALRNF
160 170 180 190 200
GNSLGNCMYD KYYLREVGKM KPPTYHFDSG DLFRKTDPAA RESFIKKQKT
210 220 230 240 250
LNSTRTVNNQ PLVNKGEQLA PRRAAELNDE QTREIEMYAD EELDNIFVED
260 270 280 290 300
DIIAHLAVAE DTAHPAANNH HSEKAGTQIN NKDKGSHNSA KPVQRSHTYP
310 320 330 340 350
VAVPQNTSDS VGNAVTDTSP KTLFDPLKPN TGTPSPKFIS ARAAAAAEGV
360 370 380 390 400
VSAPFTNNFN PRLDSPSIRK TSIIDHSKSL PVQRASVLPI IKQSSQTSPV
410 420 430 440 450
SNNSMIRDSE SIINERKENI GLIGVKRSLH DSTTSHNKSD LMRTNSDPQS
460
AMRSRENYDA TVDKKAKKG
Length:469
Mass (Da):51,961
Last modified:February 1, 1996 - v2
Checksum:iE6B8B538D28B899D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → S in CAA51021 (PubMed:8290356).Curated1
Sequence conflicti84D → E in CAA51021 (PubMed:8290356).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72220 Genomic DNA Translation: CAA51021.1
CU329670 Genomic DNA Translation: CAA91896.1
PIRiS41496
RefSeqiNP_593207.1, NM_001018603.2

Genome annotation databases

EnsemblFungiiSPAC30D11.10.1; SPAC30D11.10.1:pep; SPAC30D11.10
GeneIDi2543086
KEGGispo:SPAC30D11.10

Similar proteinsi

Entry informationi

Entry nameiRAD22_SCHPO
AccessioniPrimary (citable) accession number: P36592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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