P36586 (YPT5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP-binding protein ypt5

Gene names

Name:	ypt5
ORF Names:	SPAC6F6.15

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1 to G0 transition Inferred from mutant phenotype PubMed 19366728. Source: PomBase cellular response to nitrogen starvation Inferred from mutant phenotype PubMed 19366728. Source: PomBase endocytosis Inferred from sequence orthology. Source: PomBase protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of intracellular protein transport Inferred by curator. Source: PomBase regulation of vesicle fusion Inferred from mutant phenotype Ref.1. Source: PomBase small GTPase mediated signal transduction Inferred by curator. Source: PomBase
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase late endosome Inferred from sequence orthology. Source: PomBase nucleus Inferred from direct assay PubMed 16823372. Source: PomBase plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from direct assay Ref.1. Source: PomBase GTPase activity Inferred from sequence orthology. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	GTP-binding protein ypt5		PRO_0000121312
Regions
	Nucleotide binding	21 – 28	8	GTP By similarity
	Nucleotide binding	70 – 74	5	GTP By similarity
	Nucleotide binding	128 – 131	4	GTP By similarity
	Motif	43 – 51	9	Effector region Potential
Amino acid modifications
	Modified residue	211	1	Cysteine methyl ester
	Lipidation	209	1	S-geranylgeranyl cysteine Ref.3
	Lipidation	211	1	S-geranylgeranyl cysteine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P36586 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 759AA52930C4ED2D	FASTA	211	22,985
	10 20 30 40 50 60 MASNTAPKNV VTINQKLVLL GDSAVGKSSL VLRFVKDQFD DYRESTIGAA FLTQTLPIDE 70 80 90 100 110 120 NTSVKLEIWD TAGQERYKSL APMYYRNANC AIVVYDITQA ASLEKAKSWI KELQRQAPEG 130 140 150 160 170 180 IVIALAGNKL DLAQERRAVE KADAEAYAAE ANLLFFETSA KTAENVNELF TAIAKKLPLE 190 200 210 DKLNQARGAV NRGVNLSEAR PAAQPSGSCS C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator." Armstrong J., Craighead M.W., Watson R., Ponnambalam S., Bowden S. Mol. Biol. Cell 4:583-592(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[3]	"Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants." Giannakouros T., Newman C.M., Craighead M.W., Armstrong J., Magee A.I. J. Biol. Chem. 268:24467-24474(1993) [PubMed] [Europe PMC] [Abstract] Cited for: ISOPRENYLATION AT CYS-209 AND CYS-211.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22220 Genomic DNA. Translation: CAA80223.1. CU329670 Genomic DNA. Translation: CAB11737.1.
PIR	A47733. S34729.
RefSeq	NP_593907.1. NM_001019337.2.
3D structure databases
ProteinModelPortal	P36586.
SMR	P36586. Positions 16-178.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPAC6F6.15-1.
Proteomic databases
PaxDb	P36586.
PRIDE	P36586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC6F6.15.1; SPAC6F6.15.1:pep; SPAC6F6.15.
GeneID	2542248.
KEGG	spo:SPAC6F6.15.
Organism-specific databases
PomBase	SPAC6F6.15.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
KO	K07976.
OMA	GTQGKIC.
OrthoDB	EOG4S1XHJ.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20803313.

Entry information

Entry name

YPT5_SCHPO

Accession

Primary (citable) accession number: P36586

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program