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Protein

GTP-binding protein ypt5

Gene

ypt5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPBy similarity
Nucleotide bindingi70 – 745GTPBy similarity
Nucleotide bindingi128 – 1314GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein ypt5
Gene namesi
Name:ypt5
ORF Names:SPAC6F6.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6F6.15.
PomBaseiSPAC6F6.15. ypt5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • early endosome Source: GO_Central
  • early endosome membrane Source: CACAO
  • endocytic vesicle Source: GO_Central
  • late endosome Source: PomBase
  • nucleus Source: PomBase
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211GTP-binding protein ypt5PRO_0000121312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi209 – 2091S-geranylgeranyl cysteine1 Publication
Modified residuei211 – 2111Cysteine methyl ester1 Publication
Lipidationi211 – 2111S-geranylgeranyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP36586.

Interactioni

Protein-protein interaction databases

BioGridi278718. 1 interaction.
MINTiMINT-4688767.

Structurei

3D structure databases

ProteinModelPortaliP36586.
SMRiP36586. Positions 16-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 519Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiP36586.
KOiK07889.
OMAiGASFFRY.
OrthoDBiEOG7BGHXR.
PhylomeDBiP36586.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNTAPKNV VTINQKLVLL GDSAVGKSSL VLRFVKDQFD DYRESTIGAA
60 70 80 90 100
FLTQTLPIDE NTSVKLEIWD TAGQERYKSL APMYYRNANC AIVVYDITQA
110 120 130 140 150
ASLEKAKSWI KELQRQAPEG IVIALAGNKL DLAQERRAVE KADAEAYAAE
160 170 180 190 200
ANLLFFETSA KTAENVNELF TAIAKKLPLE DKLNQARGAV NRGVNLSEAR
210
PAAQPSGSCS C
Length:211
Mass (Da):22,985
Last modified:June 1, 1994 - v1
Checksum:i759AA52930C4ED2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22220 Genomic DNA. Translation: CAA80223.1.
CU329670 Genomic DNA. Translation: CAB11737.1.
PIRiA47733.
S34729.
RefSeqiNP_593907.1. NM_001019337.2.

Genome annotation databases

EnsemblFungiiSPAC6F6.15.1; SPAC6F6.15.1:pep; SPAC6F6.15.
GeneIDi2542248.
KEGGispo:SPAC6F6.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22220 Genomic DNA. Translation: CAA80223.1.
CU329670 Genomic DNA. Translation: CAB11737.1.
PIRiA47733.
S34729.
RefSeqiNP_593907.1. NM_001019337.2.

3D structure databases

ProteinModelPortaliP36586.
SMRiP36586. Positions 16-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278718. 1 interaction.
MINTiMINT-4688767.

Proteomic databases

MaxQBiP36586.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6F6.15.1; SPAC6F6.15.1:pep; SPAC6F6.15.
GeneIDi2542248.
KEGGispo:SPAC6F6.15.

Organism-specific databases

EuPathDBiFungiDB:SPAC6F6.15.
PomBaseiSPAC6F6.15. ypt5.

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiP36586.
KOiK07889.
OMAiGASFFRY.
OrthoDBiEOG7BGHXR.
PhylomeDBiP36586.

Miscellaneous databases

PROiP36586.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Schizosaccharomyces pombe ypt5: a homologue of the rab5 endosome fusion regulator."
    Armstrong J., Craighead M.W., Watson R., Ponnambalam S., Bowden S.
    Mol. Biol. Cell 4:583-592(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants."
    Giannakouros T., Newman C.M., Craighead M.W., Armstrong J., Magee A.I.
    J. Biol. Chem. 268:24467-24474(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOPRENYLATION AT CYS-209 AND CYS-211, METHYLATION AT CYS-211.

Entry informationi

Entry nameiYPT5_SCHPO
AccessioniPrimary (citable) accession number: P36586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.