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Protein

Protein kinase C-like 2

Gene

pck2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of the cell shape. Target of the inhibitor staurosporine.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei712ATPPROSITE-ProRule annotation1
Active sitei808Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri405 – 453Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri473 – 523Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi689 – 697ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • fungal-type cell wall biogenesis Source: PomBase
  • intracellular signal transduction Source: GO_Central
  • negative regulation of peptidyl-tyrosine phosphorylation Source: PomBase
  • peptidyl-serine phosphorylation Source: GO_Central
  • regulation of alpha-glucan biosynthetic process Source: PomBase
  • regulation of cell wall (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell shape
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.11.13 5613
ReactomeiR-SPO-5625740 RHO GTPases activate PKNs

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like 2 (EC:2.7.11.13)
Gene namesi
Name:pck2
Synonyms:pkc1, sts6
ORF Names:SPBC12D12.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC12D12.04c
PomBaseiSPBC12D12.04c pck2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557411 – 1016Protein kinase C-like 2Add BLAST1016

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei984Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36583
PaxDbiP36583
PRIDEiP36583

PTM databases

iPTMnetiP36583

Interactioni

Subunit structurei

Interacts with rho2.1 Publication

Protein-protein interaction databases

BioGridi276204, 32 interactors
STRINGi4896.SPBC12D12.04c.1

Structurei

3D structure databases

ProteinModelPortaliP36583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 68REM-1 1PROSITE-ProRule annotationAdd BLAST68
Domaini111 – 188REM-1 2PROSITE-ProRule annotationAdd BLAST78
Domaini683 – 942Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini943 – 1013AGC-kinase C-terminalAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi554 – 560Poly-His7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri405 – 453Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri473 – 523Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000176156
InParanoidiP36583
KOiK18050
OMAiLCKEDMW
OrthoDBiEOG092C0HH3
PhylomeDBiP36583

Family and domain databases

CDDicd00029 C1, 2 hits
cd08689 C2_fungal_Pkc1p, 1 hit
cd11620 HR1_PKC-like_2_fungi, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR037778 C2_fungal_PKC
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR037312 PKC-like_HR1
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF02185 HR1, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00742 Hr1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51860 REM_1, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P36583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMIDEAITE VVRKIERERS VIHGALSMKR LTQNQTVHQQ LHSNIEESKK
60 70 80 90 100
SIIYLEERLE KLKLRKNGVR KSNSEKPSVG IEKNPSFSTT KSAKSFSSTS
110 120 130 140 150
SNIDSNLDLL NYDTPLTISK ISFLLQQLEF KLSVEEQYRK GIEKMAKLYE
160 170 180 190 200
REHDRRSIAE AEKKYVESAQ KITLLKQALK RYHDLHIEID EEDVPSTESR
210 220 230 240 250
GNLNARRPQS GLLKITVGSL RNVTHSAGIS KQTEMIVAIR AEDLERARTR
260 270 280 290 300
PSRTDRFNET FEIDLEKTNE VEIVVYEKKN EKLLLPVGLL WIRLSDLVEK
310 320 330 340 350
QRRKKVEQEV SDKGWVSADK MINQRLSIFL PSALNNISKP ESTDRPNTAS
360 370 380 390 400
GNQSVSAWFS LEPMGQINLT MNFTKHNTRK RPMDAGLGRQ GAIRQRKESV
410 420 430 440 450
HEVYGHKFLQ HQFYQIMRCA LCGEFLKNAA GMQCIDCHYT CHKKCYPKVV
460 470 480 490 500
TKCISKSSDS ASSEYEKINH RIPHHFESHT NIGANWCCHC GYILPLGRKT
510 520 530 540 550
ARKCTECGIT AHAQCVHLVP DFCGMSMEMA NRVISEIRTT KIYKAQQHKQ
560 570 580 590 600
KSSHHKHHHH KKSKSSSSKH KENDKASVSI TTTTTPSITP ADPVPTSPKP
610 620 630 640 650
LAIEPVKRKP VHAGNLEVTS VSDNKLGATV QVVEQKVDDK ADALTKPPSL
660 670 680 690 700
DAVKEPIPVP SVETSVVAQD LTHKAKRIGL EDFTFLSVLG KGNFGKVMLA
710 720 730 740 750
ELKSEKQLYA IKVLKKEFIL ENDEVESTKS EKRVFLVANR ERHPFLVNLH
760 770 780 790 800
SCFQTETRIY FVMDFVSGGD LMLHIQQEQF SRRRAQFYAA EVCLALKYFH
810 820 830 840 850
DNGIIYRDLK LDNILLSPDG HVKVADYGLC KEDMWHDNTT ATFCGTPEFM
860 870 880 890 900
APEILLEQQY TRSVDWWAFG VLIYQMLLGQ SPFRGEDEEE IFDAILSDEP
910 920 930 940 950
LYPIHMPRDS VSILQQLLTR DPKKRLGSGP NDAEDVMTHP FFSNINWDDI
960 970 980 990 1000
YHKRTQPPYI PSLNSPTDTK YFDEEFTREL PVLTPVNSIL TKEMQQHFEG
1010
FSYSCEDDKP STTDNA
Length:1,016
Mass (Da):116,005
Last modified:May 30, 2000 - v2
Checksum:i060CDC4F718A0069
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152E → V in BAA03268 (PubMed:8491190).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14338 Genomic DNA Translation: BAA03268.1
L07637 Genomic DNA Translation: AAA35323.1
CU329671 Genomic DNA Translation: CAA22678.1
AB027824 Genomic DNA Translation: BAA87128.1
PIRiA46079
RefSeqiNP_595950.1, NM_001021859.2

Genome annotation databases

EnsemblFungiiSPBC12D12.04c.1; SPBC12D12.04c.1:pep; SPBC12D12.04c
GeneIDi2539649
KEGGispo:SPBC12D12.04c

Similar proteinsi

Entry informationi

Entry nameiPCK2_SCHPO
AccessioniPrimary (citable) accession number: P36583
Secondary accession number(s): Q9UU42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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