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Protein

Protein kinase C-like 1

Gene

pck1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in the control of the cell shape. Target of the inhibitor staurosporine.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei693ATPPROSITE-ProRule annotation1
Active sitei789Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri413 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri480 – 530Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi670 – 678ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell shape
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.11.13. 5613.
ReactomeiR-SPO-5625740. RHO GTPases activate PKNs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like 1 (EC:2.7.11.13)
Gene namesi
Name:pck1
ORF Names:SPAC17G8.14c, SPAC22H10.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17G8.14c.
PomBaseiSPAC17G8.14c. pck1.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell septum Source: UniProtKB-SubCell
  • cytosol Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557401 – 988Protein kinase C-like 1Add BLAST988

Proteomic databases

MaxQBiP36582.
PRIDEiP36582.

Interactioni

Protein-protein interaction databases

BioGridi278761. 104 interactors.
MINTiMINT-4688688.
STRINGi4896.SPAC17G8.14c.1.

Structurei

3D structure databases

ProteinModelPortaliP36582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 78REM 1Add BLAST73
Repeati119 – 192REM 2Add BLAST74
Domaini664 – 923Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini924 – 988AGC-kinase C-terminalAdd BLAST65

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri413 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri480 – 530Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000176156.
InParanoidiP36582.
KOiK02677.
OrthoDBiEOG092C0HH3.
PhylomeDBiP36582.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF02185. HR1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00742. Hr1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P36582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQLDDALQD AYKKVEREES LILGAKAMVA STKNPEVKRR LESNIAVSEN
60 70 80 90 100
NIKYLRERID ALKVESGSER ESQSDKDSSK KYSDSAKSTN SDDHLLSYNR
110 120 130 140 150
SAFDLFNSEK PLSPEKISTM LQHLQMRLSI EQQCVSGIEK IMSLYSKEQK
160 170 180 190 200
DKTDVIIKLK EGKQKVNLLK RSLKRYNELH IPFDISTPSS EEKQQASGLN
210 220 230 240 250
FRGLAKPISG TLKVTIHSLR NIEHTSFLQT HSFTMPSYAV LYVDDAQVAK
260 270 280 290 300
SRISQTDTWD ETFIFDVHRA KEFQIIIYEK KKDFDIPIAL ILIPTTIIAE
310 320 330 340 350
ELRRKRNIQE MSETSWKPSI AESASRSDEK GSKSDPINAP NSSSSISTNS
360 370 380 390 400
PLAPTAYYKL LSKSWLSLEP VGQICISLSF SKRTTKRQFP ETGLGRQGAI
410 420 430 440 450
RQKKEDVVAS QVGHQFVQRQ FYQIMRCAVC AELFSYSPGL QCENCSFVCH
460 470 480 490 500
KKCVTKVLAS CIAQSNSEKS DFGGLRYRIP HRFEPFNSLG AQWCAHCGFF
510 520 530 540 550
LPLRRKDCFK CVECGITCHG QCAHLIPDYC GMSNDLKHQL LTELEVSKRP
560 570 580 590 600
KKPELPNQEN KTTNEKVYRK PLSSQNTFDT LPTISQGLLA ATQPVTSVLN
610 620 630 640 650
TSPLPKTPEK DRSLNVTPSS STPTPASVLA PPSSASLSSS KDANRSVPES
660 670 680 690 700
PRREKKNRVT LDDFTFLAVL GKGNFGKVML AEYKVNKKFY AIKVLKKEAI
710 720 730 740 750
LKNEELESLK TEKHVFEVAN KEKHPFLLNL FASFQTSTRV YFVMEYILGG
760 770 780 790 800
DLMVHIQRQQ FSVKRARFYG AEVCLALKYF HENGIAYRDL KLDNILLCPD
810 820 830 840 850
GHIRIADYGL CKENMLLGNT TSTFCGTPEF MAPEILLEQQ YSKDVDWWAF
860 870 880 890 900
GVLMYQMLLG QSPFKGEDEE EIFDAILSDE PLFPINMPAD AVSLLRGLLT
910 920 930 940 950
RDPNQRLGSG PKDANEVMAH PFFASIVWDD LYNKLYEPSY KPLINDPRDL
960 970 980
NNFDEEFTSA CPTLTPVNTV LTRQQQECFR GFSSFATE
Length:988
Mass (Da):111,784
Last modified:October 1, 1996 - v2
Checksum:i0969BDEC1AB43C4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 35AMVASTKNP → SNGGFDGES (PubMed:8491190).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14337 Genomic DNA. Translation: BAA03267.1.
CU329670 Genomic DNA. Translation: CAA93697.1.
AB027982 Genomic DNA. Translation: BAA87286.1.
PIRiS35362.
RefSeqiNP_593737.2. NM_001019168.2.

Genome annotation databases

EnsemblFungiiSPAC17G8.14c.1; SPAC17G8.14c.1:pep; SPAC17G8.14c.
GeneIDi2542293.
KEGGispo:SPAC17G8.14c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPCK1_SCHPO
AccessioniPrimary (citable) accession number: P36582
Secondary accession number(s): Q9UTU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families