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Protein

60S ribosomal protein L4

Gene

RPL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174444-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Alternative name(s):
60S ribosomal protein L1
Gene namesi
Name:RPL4
Synonyms:RPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:10353. RPL4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6124.
OpenTargetsiENSG00000174444.
PharmGKBiPA34749.

Polymorphism and mutation databases

BioMutaiRPL4.
DMDMi22002063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001293502 – 42760S ribosomal protein L4Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei14N6-acetyllysineCombined sources1
Modified residuei97Omega-N-methylarginineBy similarity1
Modified residuei106N6-acetyllysineCombined sources1
Modified residuei259N6-acetyllysineBy similarity1
Modified residuei266PhosphothreonineCombined sources1
Modified residuei290PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei300CitrullineBy similarity1
Modified residuei333N6-acetyllysineCombined sources1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei364N6-acetyllysine; alternateBy similarity1
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei365PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP36578.
MaxQBiP36578.
PaxDbiP36578.
PeptideAtlasiP36578.
PRIDEiP36578.
TopDownProteomicsiP36578.

2D gel databases

SWISS-2DPAGEP36578.

PTM databases

iPTMnetiP36578.
PhosphoSitePlusiP36578.
SwissPalmiP36578.

Miscellaneous databases

PMAP-CutDBP36578.

Expressioni

Gene expression databases

BgeeiENSG00000174444.
CleanExiHS_RPL4.
ExpressionAtlasiP36578. baseline and differential.
GenevisibleiP36578. HS.

Organism-specific databases

HPAiHPA034600.

Interactioni

Subunit structurei

May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428582EBI-348313,EBI-466029

Protein-protein interaction databases

BioGridi112044. 203 interactors.
DIPiDIP-27559N.
IntActiP36578. 53 interactors.
MINTiMINT-1034893.
STRINGi9606.ENSP00000311430.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LC1-427[»]
4V6Xelectron microscopy5.00CC1-427[»]
5A8Lelectron microscopy3.80H1-427[»]
5AJ0electron microscopy3.50AC1-427[»]
ProteinModelPortaliP36578.
SMRiP36578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 427Lys-richAdd BLAST64

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
HOVERGENiHBG001453.
InParanoidiP36578.
KOiK02930.
OMAiHAVNTKA.
OrthoDBiEOG091G0A2I.
PhylomeDBiP36578.
TreeFamiTF300593.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL
160 170 180 190 200
PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR
360 370 380 390 400
VDKAAAAAAA LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK
410 420
AAATKKPAPE KKPAEKKPTT EEKKPAA
Length:427
Mass (Da):47,697
Last modified:January 23, 2007 - v5
Checksum:i4785ED31699CD792
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3C → V in AAA60281 (PubMed:8268230).Curated1
Sequence conflicti36I → M in AAA60281 (PubMed:8268230).Curated1
Sequence conflicti63S → R in AAA60281 (PubMed:8268230).Curated1
Sequence conflicti147V → F in AAA60281 (PubMed:8268230).Curated1
Sequence conflicti201Missing in AAA60281 (PubMed:8268230).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20868 mRNA. Translation: AAA60281.2.
D23660 mRNA. Translation: BAA04887.1.
AB061820 Genomic DNA. Translation: BAB79458.1.
AK291117 mRNA. Translation: BAF83806.1.
AK291859 mRNA. Translation: BAF84548.1.
CH471082 Genomic DNA. Translation: EAW77776.1.
BC001365 mRNA. Translation: AAH01365.1.
BC005817 mRNA. Translation: AAH05817.1.
BC007748 mRNA. Translation: AAH07748.1.
BC007996 mRNA. Translation: AAH07996.1.
BC009888 mRNA. Translation: AAH09888.1.
BC010151 mRNA. Translation: AAH10151.1.
BC014653 mRNA. Translation: AAH14653.1.
BC066925 mRNA. Translation: AAH66925.1.
BC095427 mRNA. Translation: AAH95427.1.
CCDSiCCDS10218.1.
PIRiT09551.
RefSeqiNP_000959.2. NM_000968.3.
UniGeneiHs.186350.
Hs.644628.

Genome annotation databases

EnsembliENST00000307961; ENSP00000311430; ENSG00000174444.
GeneIDi6124.
KEGGihsa:6124.
UCSCiuc002apv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20868 mRNA. Translation: AAA60281.2.
D23660 mRNA. Translation: BAA04887.1.
AB061820 Genomic DNA. Translation: BAB79458.1.
AK291117 mRNA. Translation: BAF83806.1.
AK291859 mRNA. Translation: BAF84548.1.
CH471082 Genomic DNA. Translation: EAW77776.1.
BC001365 mRNA. Translation: AAH01365.1.
BC005817 mRNA. Translation: AAH05817.1.
BC007748 mRNA. Translation: AAH07748.1.
BC007996 mRNA. Translation: AAH07996.1.
BC009888 mRNA. Translation: AAH09888.1.
BC010151 mRNA. Translation: AAH10151.1.
BC014653 mRNA. Translation: AAH14653.1.
BC066925 mRNA. Translation: AAH66925.1.
BC095427 mRNA. Translation: AAH95427.1.
CCDSiCCDS10218.1.
PIRiT09551.
RefSeqiNP_000959.2. NM_000968.3.
UniGeneiHs.186350.
Hs.644628.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LC1-427[»]
4V6Xelectron microscopy5.00CC1-427[»]
5A8Lelectron microscopy3.80H1-427[»]
5AJ0electron microscopy3.50AC1-427[»]
ProteinModelPortaliP36578.
SMRiP36578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112044. 203 interactors.
DIPiDIP-27559N.
IntActiP36578. 53 interactors.
MINTiMINT-1034893.
STRINGi9606.ENSP00000311430.

PTM databases

iPTMnetiP36578.
PhosphoSitePlusiP36578.
SwissPalmiP36578.

Polymorphism and mutation databases

BioMutaiRPL4.
DMDMi22002063.

2D gel databases

SWISS-2DPAGEP36578.

Proteomic databases

EPDiP36578.
MaxQBiP36578.
PaxDbiP36578.
PeptideAtlasiP36578.
PRIDEiP36578.
TopDownProteomicsiP36578.

Protocols and materials databases

DNASUi6124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307961; ENSP00000311430; ENSG00000174444.
GeneIDi6124.
KEGGihsa:6124.
UCSCiuc002apv.4. human.

Organism-specific databases

CTDi6124.
DisGeNETi6124.
GeneCardsiRPL4.
HGNCiHGNC:10353. RPL4.
HPAiHPA034600.
MIMi180479. gene.
neXtProtiNX_P36578.
OpenTargetsiENSG00000174444.
PharmGKBiPA34749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
HOVERGENiHBG001453.
InParanoidiP36578.
KOiK02930.
OMAiHAVNTKA.
OrthoDBiEOG091G0A2I.
PhylomeDBiP36578.
TreeFamiTF300593.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174444-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL4. human.
GeneWikiiRibosomal_protein_L4.
GenomeRNAii6124.
PMAP-CutDBP36578.
PROiP36578.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174444.
CleanExiHS_RPL4.
ExpressionAtlasiP36578. baseline and differential.
GenevisibleiP36578. HS.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL4_HUMAN
AccessioniPrimary (citable) accession number: P36578
Secondary accession number(s): A8K502
, P39029, Q4VBR0, Q969Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 171 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.