P36575 (ARRC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin-C

Alternative name(s):
Cone arrestin
Short name=C-arrestin
Short name=cArr
Retinal cone arrestin-3
X-arrestin

Gene names

Name:	ARR3
Synonyms:	ARRX, CAR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
Subunit structure	Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4. Ref.10
Tissue specificity	Inner and outer segments, and the inner plexiform regions of the retina.
Sequence similarities	Belongs to the arrestin family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: Compara regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara signal transduction Traceable author statement Ref.1. Source: ProtInc visual perception Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Traceable author statement Ref.1. Source: ProtInc photoreceptor outer segment Inferred from electronic annotation. Source: Compara synapse Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ZNF496	Q96IT1	2	EBI-718116,EBI-743906

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P36575-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P36575-2)

The sequence of this isoform differs from the canonical sequence as follows:
     359-388: SSEDIVIEEFTRKGEEESQKAVEAEGDEGS → R

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Arrestin-C		PRO_0000205203
Natural variations
	Alternative sequence	359 – 388	30	SSEDI…GDEGS → R in isoform 2.		VSP_017495
	Natural variant	44	1	L → F. Ref.9 Corresponds to variant rs17855428 [ dbSNP | Ensembl ].		VAR_025520
Experimental info
	Sequence conflict	19	1	G → V in CAG33130. Ref.7
	Sequence conflict	93	1	P → A no nucleotide entry Ref.1
	Sequence conflict	93	1	P → A in AAB84302. Ref.4
	Sequence conflict	93	1	P → A in AAC27524. Ref.4
	Sequence conflict	217	1	I → V in AAC78395. Ref.2
	Sequence conflict	356 – 357	2	EA → AS in CAI41490. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: 491F4EE4EE1ADA0D	FASTA	388	42,778
	10 20 30 40 50 60 MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF VMLTCAFRYG 70 80 90 100 110 120 RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL 130 140 150 160 170 180 PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS 190 200 210 220 230 240 AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL 250 260 270 280 290 300 YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS 310 320 330 340 350 360 TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSHEAASS 370 380 EDIVIEEFTR KGEEESQKAV EAEGDEGS
	Isoform 2 [UniParc]. Checksum: 3210415593EA6B38	FASTA	359	39,667
	10 20 30 40 50 60 MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF VMLTCAFRYG 70 80 90 100 110 120 RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL 130 140 150 160 170 180 PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS 190 200 210 220 230 240 AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL 250 260 270 280 290 300 YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS 310 320 330 340 350 TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSHEAAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"X-arrestin: a new retinal arrestin mapping to the X chromosome." Murakami A., Yajima T., Sakuma H., McLaren M.J., Inana G. FEBS Lett. 334:203-209(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[2]	"Cone arrestin identified by targeting expression of a functional family." Craft C.M., Whitmore D.H., Wiechmann A.F. J. Biol. Chem. 269:4613-4619(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[3]	Craft C.M. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"Immunolocalization of X-arrestin in human cone photoreceptors." Sakuma H., Inana G., Murakami A., Higashide T., McLaren M.J. FEBS Lett. 382:105-110(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[5]	"Isolation and characterization of the human X-arrestin gene." Sakuma H., Murakami A., Fujimaki T., Inana G. Gene 224:87-95(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Isolation of cDNA coding for human arrestin 3, retinal (X-arrestin) ARR3." Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Eye.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-44. Tissue: Eye.
[10]	"Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling." Busillo J.M., Armando S., Sengupta R., Meucci O., Bouvier M., Benovic J.L. J. Biol. Chem. 285:7805-7817(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CXCR4.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U03626 mRNA. Translation: AAC78395.1.
AF033105 mRNA. Translation: AAB84302.1.
AF076512 , AF076497, AF076498, AF076499, AF076500, AF076501, AF076502, AF076503, AF076504, AF076505, AF076506, AF076507, AF076508, AF076509, AF076510, AF076511 Genomic DNA. Translation: AAC27524.1.
EU883571 mRNA. Translation: ACG60645.1.
CR456849 mRNA. Translation: CAG33130.1.
AL357752 Genomic DNA. Translation: CAI41490.1.
AL357752 Genomic DNA. Translation: CAI41491.1.
BC012096 mRNA. Translation: AAH12096.1.

IPI

IPI00003917.
IPI00644870.

PIR

S38943.

RefSeq

NP_004303.2. NM_004312.2.

UniGene

Hs.308.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XEH	model	-	A	1-356	[»]
2A34	model	-	A	1-388	[»]

ProteinModelPortal

P36575.

ModBase

Search...

Protein-protein interaction databases

IntAct

P36575. 9 interactions.

MINT

MINT-1378211.

STRING

9606.ENSP00000311538.

Polymorphism databases

DMDM

93189450.

Proteomic databases

PaxDb

P36575.

PRIDE

P36575.

Protocols and materials databases

DNASU

407.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000307959; ENSP00000311538; ENSG00000120500.
ENST00000374495; ENSP00000363619; ENSG00000120500.

GeneID

407.

KEGG

hsa:407.

UCSC

uc004dya.3. human.
uc004dyb.2. human.

Organism-specific databases

CTD

407.

GeneCards

GC0XP069488.

H-InvDB

HIX0016849.

HGNC

HGNC:710. ARR3.

MIM

301770. gene.

neXtProt

NX_P36575.

PharmGKB

PA25004.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG302111.

HOGENOM

HOG000231319.

HOVERGEN

HBG002399.

InParanoid

P36575.

KO

K13801.

OMA

KYTKTVF.

PhylomeDB

P36575.

Enzyme and pathway databases

Pathway_Interaction_DB

txa2pathway. Thromboxane A2 receptor signaling.
cone_pathway. Visual signal transduction: Cones.

Gene expression databases

ArrayExpress

P36575.

Bgee

P36575.

CleanEx

HS_ARR3.

Genevestigator

P36575.

GermOnline

ENSG00000120500. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.640. 1 hit.
2.60.40.840. 1 hit.

InterPro

IPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]

PANTHER

PTHR11792. PTHR11792. 1 hit.

Pfam

PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]

PRINTS

PR00309. ARRESTIN.

SMART

SM01017. Arrestin_C. 1 hit.
[Graphical view]

SUPFAM

SSF81296. Ig_E-set. 2 hits.

PROSITE

PS00295. ARRESTINS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

407.

NextBio

1709.

SOURCE

Search...

Entry information

Entry name

ARRC_HUMAN

Accession

Primary (citable) accession number: P36575
Secondary accession number(s): B5B0B9 , Q5JT23, Q5JT24, Q6IBF5, Q96EN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.