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P36575

- ARRC_HUMAN

UniProt

P36575 - ARRC_HUMAN

Protein

Arrestin-C

Gene

ARR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. endocytosis Source: Ensembl
    2. regulation of protein phosphorylation Source: Ensembl
    3. signal transduction Source: ProtInc
    4. visual perception Source: ProtInc

    Keywords - Biological processi

    Sensory transduction, Vision

    Enzyme and pathway databases

    SignaLinkiP36575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arrestin-C
    Alternative name(s):
    Cone arrestin
    Short name:
    C-arrestin
    Short name:
    cArr
    Retinal cone arrestin-3
    X-arrestin
    Gene namesi
    Name:ARR3
    Synonyms:ARRX, CAR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:710. ARR3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. photoreceptor inner segment Source: MGI
    3. photoreceptor outer segment Source: Ensembl
    4. synapse Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25004.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Arrestin-CPRO_0000205203Add
    BLAST

    Proteomic databases

    MaxQBiP36575.
    PaxDbiP36575.
    PRIDEiP36575.

    Expressioni

    Tissue specificityi

    Inner and outer segments, and the inner plexiform regions of the retina.

    Gene expression databases

    ArrayExpressiP36575.
    BgeeiP36575.
    CleanExiHS_ARR3.
    GenevestigatoriP36575.

    Interactioni

    Subunit structurei

    Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZNF496Q96IT12EBI-718116,EBI-743906

    Protein-protein interaction databases

    BioGridi106900. 24 interactions.
    IntActiP36575. 9 interactions.
    MINTiMINT-1378211.
    STRINGi9606.ENSP00000311538.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XEHmodel-A1-356[»]
    2A34model-A1-388[»]
    ProteinModelPortaliP36575.
    SMRiP36575. Positions 2-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arrestin family.Curated

    Phylogenomic databases

    eggNOGiNOG302111.
    HOGENOMiHOG000231319.
    HOVERGENiHBG002399.
    InParanoidiP36575.
    KOiK13801.
    OMAiEIFWAGV.
    OrthoDBiEOG79W954.
    PhylomeDBiP36575.
    TreeFamiTF314260.

    Family and domain databases

    Gene3Di2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProiIPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR11792. PTHR11792. 1 hit.
    PfamiPF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view]
    PRINTSiPR00309. ARRESTIN.
    SMARTiSM01017. Arrestin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 2 hits.
    PROSITEiPS00295. ARRESTINS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P36575-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF    50
    VMLTCAFRYG RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER 100
    LLHKLGDNAY PFTLQMVTNL PCSVTLQPGP EDAGKPCGID FEVKSFCAEN 150
    PEETVSKRDY VRLVVRKVQF APPEAGPGPS AQTIRRFLLS AQPLQLQAWM 200
    DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL YSLDKYTKTV 250
    FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS 300
    TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH 350
    PKPSHEAASS EDIVIEEFTR KGEEESQKAV EAEGDEGS 388
    Length:388
    Mass (Da):42,778
    Last modified:March 7, 2006 - v2
    Checksum:i491F4EE4EE1ADA0D
    GO
    Isoform 2 (identifier: P36575-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-388: SSEDIVIEEFTRKGEEESQKAVEAEGDEGS → R

    Show »
    Length:359
    Mass (Da):39,667
    Checksum:i3210415593EA6B38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191G → V in CAG33130. 1 PublicationCurated
    Sequence conflicti93 – 931P → A no nucleotide entry (PubMed:8224247)Curated
    Sequence conflicti93 – 931P → A in AAB84302. (PubMed:8612728)Curated
    Sequence conflicti93 – 931P → A in AAC27524. (PubMed:8612728)Curated
    Sequence conflicti217 – 2171I → V in AAC78395. (PubMed:8308033)Curated
    Sequence conflicti356 – 3572EA → AS in CAI41490. (PubMed:15772651)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441L → F.1 Publication
    Corresponds to variant rs17855428 [ dbSNP | Ensembl ].
    VAR_025520

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei359 – 38830SSEDI…GDEGS → R in isoform 2. 1 PublicationVSP_017495Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03626 mRNA. Translation: AAC78395.1.
    AF033105 mRNA. Translation: AAB84302.1.
    AF076512
    , AF076497, AF076498, AF076499, AF076500, AF076501, AF076502, AF076503, AF076504, AF076505, AF076506, AF076507, AF076508, AF076509, AF076510, AF076511 Genomic DNA. Translation: AAC27524.1.
    EU883571 mRNA. Translation: ACG60645.1.
    CR456849 mRNA. Translation: CAG33130.1.
    AL357752 Genomic DNA. Translation: CAI41490.1.
    AL357752 Genomic DNA. Translation: CAI41491.1.
    BC012096 mRNA. Translation: AAH12096.1.
    CCDSiCCDS14399.1. [P36575-1]
    PIRiS38943.
    RefSeqiNP_004303.2. NM_004312.2. [P36575-1]
    UniGeneiHs.308.

    Genome annotation databases

    EnsembliENST00000307959; ENSP00000311538; ENSG00000120500. [P36575-1]
    ENST00000374495; ENSP00000363619; ENSG00000120500. [P36575-2]
    GeneIDi407.
    KEGGihsa:407.
    UCSCiuc004dya.3. human. [P36575-2]
    uc004dyb.2. human. [P36575-1]

    Polymorphism databases

    DMDMi93189450.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03626 mRNA. Translation: AAC78395.1 .
    AF033105 mRNA. Translation: AAB84302.1 .
    AF076512
    , AF076497 , AF076498 , AF076499 , AF076500 , AF076501 , AF076502 , AF076503 , AF076504 , AF076505 , AF076506 , AF076507 , AF076508 , AF076509 , AF076510 , AF076511 Genomic DNA. Translation: AAC27524.1 .
    EU883571 mRNA. Translation: ACG60645.1 .
    CR456849 mRNA. Translation: CAG33130.1 .
    AL357752 Genomic DNA. Translation: CAI41490.1 .
    AL357752 Genomic DNA. Translation: CAI41491.1 .
    BC012096 mRNA. Translation: AAH12096.1 .
    CCDSi CCDS14399.1. [P36575-1 ]
    PIRi S38943.
    RefSeqi NP_004303.2. NM_004312.2. [P36575-1 ]
    UniGenei Hs.308.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XEH model - A 1-356 [» ]
    2A34 model - A 1-388 [» ]
    ProteinModelPortali P36575.
    SMRi P36575. Positions 2-371.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106900. 24 interactions.
    IntActi P36575. 9 interactions.
    MINTi MINT-1378211.
    STRINGi 9606.ENSP00000311538.

    Polymorphism databases

    DMDMi 93189450.

    Proteomic databases

    MaxQBi P36575.
    PaxDbi P36575.
    PRIDEi P36575.

    Protocols and materials databases

    DNASUi 407.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307959 ; ENSP00000311538 ; ENSG00000120500 . [P36575-1 ]
    ENST00000374495 ; ENSP00000363619 ; ENSG00000120500 . [P36575-2 ]
    GeneIDi 407.
    KEGGi hsa:407.
    UCSCi uc004dya.3. human. [P36575-2 ]
    uc004dyb.2. human. [P36575-1 ]

    Organism-specific databases

    CTDi 407.
    GeneCardsi GC0XP069488.
    H-InvDB HIX0016849.
    HGNCi HGNC:710. ARR3.
    MIMi 301770. gene.
    neXtProti NX_P36575.
    PharmGKBi PA25004.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302111.
    HOGENOMi HOG000231319.
    HOVERGENi HBG002399.
    InParanoidi P36575.
    KOi K13801.
    OMAi EIFWAGV.
    OrthoDBi EOG79W954.
    PhylomeDBi P36575.
    TreeFami TF314260.

    Enzyme and pathway databases

    SignaLinki P36575.

    Miscellaneous databases

    GeneWikii ARR3.
    GenomeRNAii 407.
    NextBioi 1709.
    PROi P36575.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36575.
    Bgeei P36575.
    CleanExi HS_ARR3.
    Genevestigatori P36575.

    Family and domain databases

    Gene3Di 2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProi IPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR11792. PTHR11792. 1 hit.
    Pfami PF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00309. ARRESTIN.
    SMARTi SM01017. Arrestin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 2 hits.
    PROSITEi PS00295. ARRESTINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "X-arrestin: a new retinal arrestin mapping to the X chromosome."
      Murakami A., Yajima T., Sakuma H., McLaren M.J., Inana G.
      FEBS Lett. 334:203-209(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "Cone arrestin identified by targeting expression of a functional family."
      Craft C.M., Whitmore D.H., Wiechmann A.F.
      J. Biol. Chem. 269:4613-4619(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    3. Craft C.M.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Immunolocalization of X-arrestin in human cone photoreceptors."
      Sakuma H., Inana G., Murakami A., Higashide T., McLaren M.J.
      FEBS Lett. 382:105-110(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    5. "Isolation and characterization of the human X-arrestin gene."
      Sakuma H., Murakami A., Fujimaki T., Inana G.
      Gene 224:87-95(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Isolation of cDNA coding for human arrestin 3, retinal (X-arrestin) ARR3."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Eye.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-44.
      Tissue: Eye.
    10. "Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."
      Busillo J.M., Armando S., Sengupta R., Meucci O., Bouvier M., Benovic J.L.
      J. Biol. Chem. 285:7805-7817(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CXCR4.

    Entry informationi

    Entry nameiARRC_HUMAN
    AccessioniPrimary (citable) accession number: P36575
    Secondary accession number(s): B5B0B9
    , Q5JT23, Q5JT24, Q6IBF5, Q96EN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3