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Protein

Arrestin-C

Gene

ARR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

GO - Biological processi

  • endocytosis Source: Ensembl
  • regulation of protein phosphorylation Source: Ensembl
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120500-MONOMER.
SignaLinkiP36575.

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-C
Alternative name(s):
Cone arrestin
Short name:
C-arrestin
Short name:
cArr
Retinal cone arrestin-3
X-arrestin
Gene namesi
Name:ARR3
Synonyms:ARRX, CAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:710. ARR3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • photoreceptor inner segment Source: MGI
  • photoreceptor outer segment Source: Ensembl
  • synapse Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi407.
OpenTargetsiENSG00000120500.
PharmGKBiPA25004.

Polymorphism and mutation databases

BioMutaiARR3.
DMDMi93189450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002052031 – 388Arrestin-CAdd BLAST388

Proteomic databases

EPDiP36575.
MaxQBiP36575.
PaxDbiP36575.
PeptideAtlasiP36575.
PRIDEiP36575.

PTM databases

PhosphoSitePlusiP36575.

Expressioni

Tissue specificityi

Inner and outer segments, and the inner plexiform regions of the retina.

Gene expression databases

BgeeiENSG00000120500.
CleanExiHS_ARR3.
ExpressionAtlasiP36575. baseline and differential.
GenevisibleiP36575. HS.

Organism-specific databases

HPAiCAB017460.

Interactioni

Subunit structurei

Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PLK4O004443EBI-718116,EBI-746202
ZBTB43O432983EBI-718116,EBI-740718
ZNF496Q96IT15EBI-718116,EBI-743906

Protein-protein interaction databases

BioGridi106900. 10 interactors.
IntActiP36575. 11 interactors.
MINTiMINT-1378211.
STRINGi9606.ENSP00000311538.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEHmodel-A1-356[»]
2A34model-A1-388[»]
ProteinModelPortaliP36575.
SMRiP36575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP36575.
KOiK13801.
PhylomeDBiP36575.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR033042. ARR3.
IPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PTHR11792:SF19. PTHR11792:SF19. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36575-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF
60 70 80 90 100
VMLTCAFRYG RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER
110 120 130 140 150
LLHKLGDNAY PFTLQMVTNL PCSVTLQPGP EDAGKPCGID FEVKSFCAEN
160 170 180 190 200
PEETVSKRDY VRLVVRKVQF APPEAGPGPS AQTIRRFLLS AQPLQLQAWM
210 220 230 240 250
DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL YSLDKYTKTV
260 270 280 290 300
FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS
310 320 330 340 350
TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH
360 370 380
PKPSHEAASS EDIVIEEFTR KGEEESQKAV EAEGDEGS
Length:388
Mass (Da):42,778
Last modified:March 7, 2006 - v2
Checksum:i491F4EE4EE1ADA0D
GO
Isoform 2 (identifier: P36575-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-388: SSEDIVIEEFTRKGEEESQKAVEAEGDEGS → R

Show »
Length:359
Mass (Da):39,667
Checksum:i3210415593EA6B38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19G → V in CAG33130 (Ref. 7) Curated1
Sequence conflicti93P → A no nucleotide entry (PubMed:8224247).Curated1
Sequence conflicti93P → A in AAB84302 (PubMed:8612728).Curated1
Sequence conflicti93P → A in AAC27524 (PubMed:8612728).Curated1
Sequence conflicti217I → V in AAC78395 (PubMed:8308033).Curated1
Sequence conflicti356 – 357EA → AS in CAI41490 (PubMed:15772651).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02552044L → F.1 PublicationCorresponds to variant rs17855428dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017495359 – 388SSEDI…GDEGS → R in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03626 mRNA. Translation: AAC78395.1.
AF033105 mRNA. Translation: AAB84302.1.
AF076512
, AF076497, AF076498, AF076499, AF076500, AF076501, AF076502, AF076503, AF076504, AF076505, AF076506, AF076507, AF076508, AF076509, AF076510, AF076511 Genomic DNA. Translation: AAC27524.1.
EU883571 mRNA. Translation: ACG60645.1.
CR456849 mRNA. Translation: CAG33130.1.
AL357752 Genomic DNA. Translation: CAI41490.1.
AL357752 Genomic DNA. Translation: CAI41491.1.
BC012096 mRNA. Translation: AAH12096.1.
CCDSiCCDS14399.1. [P36575-1]
PIRiS38943.
RefSeqiNP_004303.2. NM_004312.2. [P36575-1]
UniGeneiHs.308.

Genome annotation databases

EnsembliENST00000307959; ENSP00000311538; ENSG00000120500. [P36575-1]
ENST00000374495; ENSP00000363619; ENSG00000120500. [P36575-2]
GeneIDi407.
KEGGihsa:407.
UCSCiuc004dya.4. human. [P36575-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03626 mRNA. Translation: AAC78395.1.
AF033105 mRNA. Translation: AAB84302.1.
AF076512
, AF076497, AF076498, AF076499, AF076500, AF076501, AF076502, AF076503, AF076504, AF076505, AF076506, AF076507, AF076508, AF076509, AF076510, AF076511 Genomic DNA. Translation: AAC27524.1.
EU883571 mRNA. Translation: ACG60645.1.
CR456849 mRNA. Translation: CAG33130.1.
AL357752 Genomic DNA. Translation: CAI41490.1.
AL357752 Genomic DNA. Translation: CAI41491.1.
BC012096 mRNA. Translation: AAH12096.1.
CCDSiCCDS14399.1. [P36575-1]
PIRiS38943.
RefSeqiNP_004303.2. NM_004312.2. [P36575-1]
UniGeneiHs.308.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEHmodel-A1-356[»]
2A34model-A1-388[»]
ProteinModelPortaliP36575.
SMRiP36575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106900. 10 interactors.
IntActiP36575. 11 interactors.
MINTiMINT-1378211.
STRINGi9606.ENSP00000311538.

PTM databases

PhosphoSitePlusiP36575.

Polymorphism and mutation databases

BioMutaiARR3.
DMDMi93189450.

Proteomic databases

EPDiP36575.
MaxQBiP36575.
PaxDbiP36575.
PeptideAtlasiP36575.
PRIDEiP36575.

Protocols and materials databases

DNASUi407.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307959; ENSP00000311538; ENSG00000120500. [P36575-1]
ENST00000374495; ENSP00000363619; ENSG00000120500. [P36575-2]
GeneIDi407.
KEGGihsa:407.
UCSCiuc004dya.4. human. [P36575-1]

Organism-specific databases

CTDi407.
DisGeNETi407.
GeneCardsiARR3.
H-InvDBHIX0016849.
HGNCiHGNC:710. ARR3.
HPAiCAB017460.
MIMi301770. gene.
neXtProtiNX_P36575.
OpenTargetsiENSG00000120500.
PharmGKBiPA25004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP36575.
KOiK13801.
PhylomeDBiP36575.
TreeFamiTF314260.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120500-MONOMER.
SignaLinkiP36575.

Miscellaneous databases

ChiTaRSiARR3. human.
GeneWikiiARR3.
GenomeRNAii407.
PROiP36575.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120500.
CleanExiHS_ARR3.
ExpressionAtlasiP36575. baseline and differential.
GenevisibleiP36575. HS.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR033042. ARR3.
IPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PTHR11792:SF19. PTHR11792:SF19. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARRC_HUMAN
AccessioniPrimary (citable) accession number: P36575
Secondary accession number(s): B5B0B9
, Q5JT23, Q5JT24, Q6IBF5, Q96EN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.