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Protein

Acid shock protein

Gene

asr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0).1 Publication

GO - Biological processi

  • response to zinc ion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6855-MONOMER.
ECOL316407:JW5826-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid shock protein
Gene namesi
Name:asr
Ordered Locus Names:b1597, JW5826
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12149. asr.

Subcellular locationi

GO - Cellular componenti

  • periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Propeptidei22 – 58371 PublicationPRO_0000269503Add
BLAST
Chaini59 – 10244Acid shock proteinPRO_0000002402Add
BLAST

Post-translational modificationi

Proteolytic processing gives rise to the active protein.1 Publication

Proteomic databases

PaxDbiP36560.
PRIDEiP36560.

Expressioni

Inductioni

By high environmental acidity.

Interactioni

Protein-protein interaction databases

BioGridi4259122. 16 interactions.
DIPiDIP-9183N.
IntActiP36560. 5 interactions.
MINTiMINT-1320044.
STRINGi511145.b1597.

Structurei

3D structure databases

ProteinModelPortaliP36560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Asr family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OMAiTTHVKKH.
OrthoDBiEOG6S52GD.

Family and domain databases

HAMAPiMF_00546. Asr.
InterProiIPR023497. Acid_shock.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLALVVA AAMGLSSAAF AAETTTTPAP TATTTKAAPA KTTHHKKQHK
60 70 80 90 100
AAPAQKAQAA KKHHKNTKAE QKAPEQKAQA AKKHAKKHSH QQPAKPAAQP

AA
Length:102
Mass (Da):10,591
Last modified:April 27, 2001 - v3
Checksum:i3E92AAE86D3975AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF405541 Genomic DNA. Translation: AAA23500.2.
U00096 Genomic DNA. Translation: AAC74669.2.
AP009048 Genomic DNA. Translation: BAA15331.2.
PIRiG64915.
RefSeqiNP_416114.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74669; AAC74669; b1597.
BAA15331; BAA15331; BAA15331.
GeneIDi945103.
KEGGiecj:JW5826.
eco:b1597.
PATRICi32118496. VBIEscCol129921_1668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF405541 Genomic DNA. Translation: AAA23500.2.
U00096 Genomic DNA. Translation: AAC74669.2.
AP009048 Genomic DNA. Translation: BAA15331.2.
PIRiG64915.
RefSeqiNP_416114.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP36560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259122. 16 interactions.
DIPiDIP-9183N.
IntActiP36560. 5 interactions.
MINTiMINT-1320044.
STRINGi511145.b1597.

Proteomic databases

PaxDbiP36560.
PRIDEiP36560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74669; AAC74669; b1597.
BAA15331; BAA15331; BAA15331.
GeneIDi945103.
KEGGiecj:JW5826.
eco:b1597.
PATRICi32118496. VBIEscCol129921_1668.

Organism-specific databases

EchoBASEiEB2069.
EcoGeneiEG12149. asr.

Phylogenomic databases

OMAiTTHVKKH.
OrthoDBiEOG6S52GD.

Enzyme and pathway databases

BioCyciEcoCyc:G6855-MONOMER.
ECOL316407:JW5826-MONOMER.

Miscellaneous databases

PROiP36560.

Family and domain databases

HAMAPiMF_00546. Asr.
InterProiIPR023497. Acid_shock.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The acid-inducible asr gene in Escherichia coli: transcriptional control by the phoBR operon."
    Suziedeliene E., Suziedelis K., Garbenciute V., Normark S.
    J. Bacteriol. 181:2084-2093(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / N2212.
  2. Suziedeliene E.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Molecular characterization of the acid-inducible asr gene of Escherichia coli and its role in acid stress response."
    Seputiene V., Motiejunas D., Suziedelis K., Tomenius H., Normark S., Melefors O., Suziedeliene E.
    J. Bacteriol. 185:2475-2484(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-31 AND 59-68, PROTEOLYTIC PROCESSING, FUNCTION, IDENTIFICATION OF START CODON.

Entry informationi

Entry nameiASR_ECOLI
AccessioniPrimary (citable) accession number: P36560
Secondary accession number(s): P77267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.