Sensor protein BasS - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

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P36557 (BASS_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sensor protein BasS
EC=2.7.13.3

Gene names

Name:	basS
Synonyms:	parB, pmrB
Ordered Locus Names:	STM4291

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. Ref.3
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Induction	The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions. Ref.3
Post-translational modification	Autophosphorylated. Ref.3
Sequence similarities	Contains 1 HAMP domain. Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system Virulence
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 356

356

Sensor protein BasS

PRO_0000074702

Regions

Topological domain

1 – 13

Cytoplasmic Potential

Transmembrane

14 – 34

Helical; Potential

Topological domain

35 – 64

Periplasmic Potential

Transmembrane

65 – 88

Helical; Potential

Topological domain

89 – 356

268

Cytoplasmic Potential

Domain

89 – 141

HAMP

Domain

149 – 356

208

Histidine kinase

Amino acid modifications

Modified residue

152

Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P36557 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 953234B125727BBD
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FASTA

356

40,262

        10         20         30         40         50         60 
MRFQRRAMTL RQRLMLTIGL ILLVFQLIST FWLWHESTEQ IQLFEQALRD NRNNDRHIMH 

        70         80         90        100        110        120 
EIREAVASLI VPGVFMVSLT LLICYQAVRR ITRPLAELQK ELEARTADNL APIAIHSSTL 

       130        140        150        160        170        180 
EIESVVSAIN QLVTRLTTTL DNERLFTADV AHELRTPLSG VRLHLELLSK THNVDVAPLI 

       190        200        210        220        230        240 
ARLDQMMDSV SQLLQLARVG QSFSSGNYQE VKLLEDVILP SYDELNTMLE TRQQTLLLPE 

       250        260        270        280        290        300 
SAADVVVRGD ATLLRMLLRN LVENAHRYSP EGTHITIHIS ADPDAIMAVE DEGPGIDESK 

       310        320        330        340        350 
CGKLSEAFVR MDSRYGGIGL GLSIVSRITQ LHQGQFFLQN RTERTGTRAW VLLKKA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence." Roland K.L., Martin L.E., Esther C.R., Spitznagel J.K. J. Bacteriol. 175:4154-4164(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[3]	"Molecular characterization of the PmrA regulon." Woesten M.M.S.M., Groisman E.A. J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION, AUTOPHOSPHORYLATION. Strain: ATCC 14028s / SGSG 2262.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13395 Genomic DNA. Translation: AAA72366.1. AE006468 Genomic DNA. Translation: AAL23115.1.
PIR	C40656.
RefSeq	NP_463156.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P36557.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM4291.
Proteomic databases
PaxDb	P36557.
PRIDE	P36557.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL23115; AAL23115; STM4291.
GeneID	1255817.
KEGG	stm:STM4291.
PATRIC	32387491. VBISalEnt20916_4513.
Phylogenomic databases
eggNOG	COG0642.
HOGENOM	HOG000127051.
KO	K07643.
OMA	WIADPHY.
ProtClustDB	PRK10755.
Enzyme and pathway databases
BRENDA	2.7.13.3. 5542.
Family and domain databases
Gene3D	1.10.287.130. 1 hit. 3.30.565.10. 1 hit.
InterPro	IPR003660. HAMP_linker_domain. IPR003594. HATPase_ATP-bd. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. [Graphical view]
Pfam	PF00672. HAMP. 1 hit. PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00304. HAMP. 1 hit. SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF47384. His_kin_homodim. 1 hit.
PROSITE	PS50885. HAMP. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BASS_SALTY

Accession

Primary (citable) accession number: P36557

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents