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P36557

- BASS_SALTY

UniProt

P36557 - BASS_SALTY

Protein

Sensor protein BasS

Gene

basS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.1 Publication

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Two-component regulatory system, Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-4322-MONOMER.
    BRENDAi2.7.13.3. 5542.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sensor protein BasS (EC:2.7.13.3)
    Gene namesi
    Name:basS
    Synonyms:parB, pmrB
    Ordered Locus Names:STM4291
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Sensor protein BasSPRO_0000074702Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei152 – 1521Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP36557.
    PRIDEiP36557.

    Expressioni

    Inductioni

    The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM4291.

    Structurei

    3D structure databases

    ProteinModelPortaliP36557.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 6430PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 356268CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8824HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 14153HAMPPROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 356208Histidine kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HAMP domain.PROSITE-ProRule annotation
    Contains 1 histidine kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000127051.
    KOiK07643.
    OMAiSINAMAP.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP36557.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR003661. EnvZ-like_dim/P.
    IPR003660. HAMP_linker_domain.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view]
    PfamiPF00672. HAMP. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00304. HAMP. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50885. HAMP. 1 hit.
    PS50109. HIS_KIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36557-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFQRRAMTL RQRLMLTIGL ILLVFQLIST FWLWHESTEQ IQLFEQALRD    50
    NRNNDRHIMH EIREAVASLI VPGVFMVSLT LLICYQAVRR ITRPLAELQK 100
    ELEARTADNL APIAIHSSTL EIESVVSAIN QLVTRLTTTL DNERLFTADV 150
    AHELRTPLSG VRLHLELLSK THNVDVAPLI ARLDQMMDSV SQLLQLARVG 200
    QSFSSGNYQE VKLLEDVILP SYDELNTMLE TRQQTLLLPE SAADVVVRGD 250
    ATLLRMLLRN LVENAHRYSP EGTHITIHIS ADPDAIMAVE DEGPGIDESK 300
    CGKLSEAFVR MDSRYGGIGL GLSIVSRITQ LHQGQFFLQN RTERTGTRAW 350
    VLLKKA 356
    Length:356
    Mass (Da):40,262
    Last modified:June 1, 1994 - v1
    Checksum:i953234B125727BBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13395 Genomic DNA. Translation: AAA72366.1.
    AE006468 Genomic DNA. Translation: AAL23115.1.
    PIRiC40656.
    RefSeqiNP_463156.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL23115; AAL23115; STM4291.
    GeneIDi1255817.
    KEGGistm:STM4291.
    PATRICi32387491. VBISalEnt20916_4513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13395 Genomic DNA. Translation: AAA72366.1 .
    AE006468 Genomic DNA. Translation: AAL23115.1 .
    PIRi C40656.
    RefSeqi NP_463156.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P36557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM4291.

    Proteomic databases

    PaxDbi P36557.
    PRIDEi P36557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL23115 ; AAL23115 ; STM4291 .
    GeneIDi 1255817.
    KEGGi stm:STM4291.
    PATRICi 32387491. VBISalEnt20916_4513.

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000127051.
    KOi K07643.
    OMAi SINAMAP.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P36557.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-4322-MONOMER.
    BRENDAi 2.7.13.3. 5542.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR003661. EnvZ-like_dim/P.
    IPR003660. HAMP_linker_domain.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view ]
    Pfami PF00672. HAMP. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00304. HAMP. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50885. HAMP. 1 hit.
    PS50109. HIS_KIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence."
      Roland K.L., Martin L.E., Esther C.R., Spitznagel J.K.
      J. Bacteriol. 175:4154-4164(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    3. "Molecular characterization of the PmrA regulon."
      Woesten M.M.S.M., Groisman E.A.
      J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, AUTOPHOSPHORYLATION.
      Strain: ATCC 14028s / SGSG 2262.

    Entry informationi

    Entry nameiBASS_SALTY
    AccessioniPrimary (citable) accession number: P36557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3