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P36557

- BASS_SALTY

UniProt

P36557 - BASS_SALTY

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Protein

Sensor protein BasS

Gene

basS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system, Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4322-MONOMER.
BRENDAi2.7.13.3. 5542.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein BasS (EC:2.7.13.3)
Gene namesi
Name:basS
Synonyms:parB, pmrB
Ordered Locus Names:STM4291
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Sensor protein BasSPRO_0000074702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP36557.
PRIDEiP36557.

Expressioni

Inductioni

The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4291.

Structurei

3D structure databases

ProteinModelPortaliP36557.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini35 – 6430PeriplasmicSequence AnalysisAdd
BLAST
Topological domaini89 – 356268CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8824HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 14153HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini149 – 356208Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000127051.
KOiK07643.
OMAiSINAMAP.
OrthoDBiEOG6G4VQG.
PhylomeDBiP36557.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36557 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFQRRAMTL RQRLMLTIGL ILLVFQLIST FWLWHESTEQ IQLFEQALRD
60 70 80 90 100
NRNNDRHIMH EIREAVASLI VPGVFMVSLT LLICYQAVRR ITRPLAELQK
110 120 130 140 150
ELEARTADNL APIAIHSSTL EIESVVSAIN QLVTRLTTTL DNERLFTADV
160 170 180 190 200
AHELRTPLSG VRLHLELLSK THNVDVAPLI ARLDQMMDSV SQLLQLARVG
210 220 230 240 250
QSFSSGNYQE VKLLEDVILP SYDELNTMLE TRQQTLLLPE SAADVVVRGD
260 270 280 290 300
ATLLRMLLRN LVENAHRYSP EGTHITIHIS ADPDAIMAVE DEGPGIDESK
310 320 330 340 350
CGKLSEAFVR MDSRYGGIGL GLSIVSRITQ LHQGQFFLQN RTERTGTRAW

VLLKKA
Length:356
Mass (Da):40,262
Last modified:June 1, 1994 - v1
Checksum:i953234B125727BBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72366.1.
AE006468 Genomic DNA. Translation: AAL23115.1.
PIRiC40656.
RefSeqiNP_463156.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23115; AAL23115; STM4291.
GeneIDi1255817.
KEGGistm:STM4291.
PATRICi32387491. VBISalEnt20916_4513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13395 Genomic DNA. Translation: AAA72366.1 .
AE006468 Genomic DNA. Translation: AAL23115.1 .
PIRi C40656.
RefSeqi NP_463156.1. NC_003197.1.

3D structure databases

ProteinModelPortali P36557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4291.

Proteomic databases

PaxDbi P36557.
PRIDEi P36557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23115 ; AAL23115 ; STM4291 .
GeneIDi 1255817.
KEGGi stm:STM4291.
PATRICi 32387491. VBISalEnt20916_4513.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000127051.
KOi K07643.
OMAi SINAMAP.
OrthoDBi EOG6G4VQG.
PhylomeDBi P36557.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-4322-MONOMER.
BRENDAi 2.7.13.3. 5542.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence."
    Roland K.L., Martin L.E., Esther C.R., Spitznagel J.K.
    J. Bacteriol. 175:4154-4164(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Molecular characterization of the PmrA regulon."
    Woesten M.M.S.M., Groisman E.A.
    J. Biol. Chem. 274:27185-27190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, AUTOPHOSPHORYLATION.
    Strain: ATCC 14028s / SGSG 2262.

Entry informationi

Entry nameiBASS_SALTY
AccessioniPrimary (citable) accession number: P36557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3