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Protein

Transcriptional regulatory protein BasR

Gene

basR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.2 Publications

Miscellaneous

The activity of the BasR protein is controlled at a post-transcriptional level by the PmrD protein, under low Mg2+ concentration conditions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi124 – 218OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAntibiotic resistance, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BasR
Gene namesi
Name:basR
Synonyms:parA, pmrA
Ordered Locus Names:STM4292
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51D → A: No activation of BasR regulated genes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810241 – 222Transcriptional regulatory protein BasRAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

Phosphorylated by BasS.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP36556.
PRIDEiP36556.

Expressioni

Inductioni

The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi99287.STM4292.

Structurei

3D structure databases

ProteinModelPortaliP36556.
SMRiP36556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

eggNOGiENOG4105XJC. Bacteria.
ENOG4111FPD. LUCA.
HOGENOMiHOG000034815.
KOiK07771.
OMAiMEHPREV.

Family and domain databases

CDDicd00156. REC. 1 hit.
cd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P36556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILIVEDDT LLLQGLILAA QTEGYACDGV STARAAEHSL ESGHYSLMVL
60 70 80 90 100
DLGLPDEDGL HFLTRIRQKK YTLPVLILTA HDTLNDRITG LDVGADDYLV
110 120 130 140 150
KPFALEELHA RIRALLRRHN NQGESELTVG NLTLNIGRHQ AWRDGQELTL
160 170 180 190 200
TPKEYALLSR LMLKAGSPVH REILYNDIYN WDNEPSTNTL EVHIHNLRDK
210 220
VGKSRIRTVR GFGYMLVATE ES
Length:222
Mass (Da):25,035
Last modified:June 1, 1994 - v1
Checksum:i3734CC2034070533
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti81H → R in strain: LT2 / SGSC1412 and S4194; resistance to polymyxin B and neutrophil proteins. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13395 Genomic DNA. Translation: AAA72365.1.
AY725348 Genomic DNA. Translation: AAV92795.1.
AE006468 Genomic DNA. Translation: AAL23116.1.
PIRiB40656.
RefSeqiNP_463157.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL23116; AAL23116; STM4292.
GeneIDi1255818.
KEGGistm:STM4292.
PATRICifig|99287.12.peg.4514.

Similar proteinsi

Entry informationi

Entry nameiBASR_SALTY
AccessioniPrimary (citable) accession number: P36556
Secondary accession number(s): Q5MN92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome