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Protein

Putative multidrug resistance protein MdtD

Gene

mdtD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2077-MONOMER.
ECOL316407:JW2062-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.26. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance protein MdtD
Gene namesi
Name:mdtD
Synonyms:yegB
Ordered Locus Names:b2077, JW2062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12136. mdtD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111PeriplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 4816CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 767PeriplasmicSequence analysis
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 1014CytoplasmicSequence analysis
Transmembranei102 – 12423HelicalSequence analysisAdd
BLAST
Topological domaini125 – 13713PeriplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 1646CytoplasmicSequence analysis
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 19611PeriplasmicSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 2247CytoplasmicSequence analysis
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 26217PeriplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 2852CytoplasmicSequence analysis
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Topological domaini307 – 34135PeriplasmicSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Topological domaini363 – 39533CytoplasmicSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Topological domaini417 – 43014PeriplasmicSequence analysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST
Topological domaini452 – 47120CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Putative multidrug resistance protein MdtDPRO_0000173406Add
BLAST

Proteomic databases

PaxDbiP36554.

Expressioni

Inductioni

Transcriptionally regulated by BaeR.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4260425. 166 interactions.
DIPiDIP-11876N.
IntActiP36554. 1 interaction.
MINTiMINT-1320504.
STRINGi511145.b2077.

Structurei

3D structure databases

ProteinModelPortaliP36554.
SMRiP36554. Positions 27-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0R. Bacteria.
ENOG410XNN3. LUCA.
HOGENOMiHOG000193484.
InParanoidiP36554.
KOiK18326.
OMAiLYLLHAK.
OrthoDBiEOG651SWK.
PhylomeDBiP36554.

Family and domain databases

HAMAPiMF_01577. MFS_MdtD.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR023721. Multi-R_MdtD_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMAQSL GESPLHMHMV
60 70 80 90 100
IVSYVLTVAV MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE
110 120 130 140 150
LLLARALQGV GGAMMVPVGR LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG
160 170 180 190 200
PALGGLLVEY ASWHWIFLIN IPVGIIGAIA TLLLMPNYTM QTRRFDLSGF
210 220 230 240 250
LLLAVGMAVL TLALDGSKGT GLSPLTIAGL VAVGVVALVL YLLHARNNNR
260 270 280 290 300
ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
310 320 330 340 350
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL
360 370 380 390 400
GWYYVLPFVL FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL
410 420 430 440 450
SMSIGVTIAG LLLGLFGSQH VSVDSGTTQT VFMYTWLSMA LIIALPAFIF
460 470
ARVPNDTHQN VAISRRKRSA Q
Length:471
Mass (Da):50,901
Last modified:November 1, 1997 - v2
Checksum:iFCAF02AD330B5F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089190 Genomic DNA. Translation: BAC06610.1.
U00096 Genomic DNA. Translation: AAC75138.1.
AP009048 Genomic DNA. Translation: BAA15933.1.
D14054 Genomic DNA. Translation: BAA03139.1.
PIRiD64974.
RefSeqiNP_416581.1. NC_000913.3.
WP_000130850.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75138; AAC75138; b2077.
BAA15933; BAA15933; BAA15933.
GeneIDi946601.
KEGGiecj:JW2062.
eco:b2077.
PATRICi32119487. VBIEscCol129921_2154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089190 Genomic DNA. Translation: BAC06610.1.
U00096 Genomic DNA. Translation: AAC75138.1.
AP009048 Genomic DNA. Translation: BAA15933.1.
D14054 Genomic DNA. Translation: BAA03139.1.
PIRiD64974.
RefSeqiNP_416581.1. NC_000913.3.
WP_000130850.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36554.
SMRiP36554. Positions 27-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260425. 166 interactions.
DIPiDIP-11876N.
IntActiP36554. 1 interaction.
MINTiMINT-1320504.
STRINGi511145.b2077.

Protein family/group databases

TCDBi2.A.1.3.26. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP36554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75138; AAC75138; b2077.
BAA15933; BAA15933; BAA15933.
GeneIDi946601.
KEGGiecj:JW2062.
eco:b2077.
PATRICi32119487. VBIEscCol129921_2154.

Organism-specific databases

EchoBASEiEB2057.
EcoGeneiEG12136. mdtD.

Phylogenomic databases

eggNOGiENOG4105C0R. Bacteria.
ENOG410XNN3. LUCA.
HOGENOMiHOG000193484.
InParanoidiP36554.
KOiK18326.
OMAiLYLLHAK.
OrthoDBiEOG651SWK.
PhylomeDBiP36554.

Enzyme and pathway databases

BioCyciEcoCyc:B2077-MONOMER.
ECOL316407:JW2062-MONOMER.

Miscellaneous databases

PROiP36554.

Family and domain databases

HAMAPiMF_01577. MFS_MdtD.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR023721. Multi-R_MdtD_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC."
    Nagakubo S., Nishino K., Hirata T., Yamaguchi A.
    J. Bacteriol. 184:4161-4167(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Novel members of the two-component signal transduction genes in Escherichia coli."
    Nagasawa S., Ishige K., Mizuno T.
    J. Biochem. 114:350-357(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-471.
    Strain: K12.
  6. "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate."
    Baranova N., Nikaido H.
    J. Bacteriol. 184:4168-4176(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiMDTD_ECOLI
AccessioniPrimary (citable) accession number: P36554
Secondary accession number(s): P76400, Q54A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: February 17, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.