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Protein

Putative multidrug resistance protein MdtD

Gene

mdtD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:B2077-MONOMER

Protein family/group databases

TCDBi2.A.1.3.26 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance protein MdtD
Gene namesi
Name:mdtD
Synonyms:yegB
Ordered Locus Names:b2077, JW2062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12136 mdtD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11PeriplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 48CytoplasmicSequence analysisAdd BLAST16
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 76PeriplasmicSequence analysis7
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 101CytoplasmicSequence analysis4
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Topological domaini125 – 137PeriplasmicSequence analysisAdd BLAST13
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 164CytoplasmicSequence analysis6
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 196PeriplasmicSequence analysisAdd BLAST11
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 224CytoplasmicSequence analysis7
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 262PeriplasmicSequence analysisAdd BLAST17
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 285CytoplasmicSequence analysis2
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 341PeriplasmicSequence analysisAdd BLAST35
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 395CytoplasmicSequence analysisAdd BLAST33
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 430PeriplasmicSequence analysisAdd BLAST14
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 471CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734061 – 471Putative multidrug resistance protein MdtDAdd BLAST471

Proteomic databases

PaxDbiP36554
PRIDEiP36554

Expressioni

Inductioni

Transcriptionally regulated by BaeR.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4260425, 175 interactors
DIPiDIP-11876N
IntActiP36554, 1 interactor
STRINGi316385.ECDH10B_2229

Structurei

3D structure databases

ProteinModelPortaliP36554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0R Bacteria
ENOG410XNN3 LUCA
HOGENOMiHOG000193484
InParanoidiP36554
KOiK18326
OMAiFKIHTFS
PhylomeDBiP36554

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01577 MFS_MdtD, 1 hit
InterProiView protein in InterPro
IPR004638 Drug-R_transpt_efflux_EmrB
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR023721 Multi-R_MdtD_put
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00711 efflux_EmrB, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P36554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMAQSL GESPLHMHMV
60 70 80 90 100
IVSYVLTVAV MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE
110 120 130 140 150
LLLARALQGV GGAMMVPVGR LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG
160 170 180 190 200
PALGGLLVEY ASWHWIFLIN IPVGIIGAIA TLLLMPNYTM QTRRFDLSGF
210 220 230 240 250
LLLAVGMAVL TLALDGSKGT GLSPLTIAGL VAVGVVALVL YLLHARNNNR
260 270 280 290 300
ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
310 320 330 340 350
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL
360 370 380 390 400
GWYYVLPFVL FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL
410 420 430 440 450
SMSIGVTIAG LLLGLFGSQH VSVDSGTTQT VFMYTWLSMA LIIALPAFIF
460 470
ARVPNDTHQN VAISRRKRSA Q
Length:471
Mass (Da):50,901
Last modified:November 1, 1997 - v2
Checksum:iFCAF02AD330B5F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089190 Genomic DNA Translation: BAC06610.1
U00096 Genomic DNA Translation: AAC75138.1
AP009048 Genomic DNA Translation: BAA15933.1
D14054 Genomic DNA Translation: BAA03139.1
PIRiD64974
RefSeqiNP_416581.1, NC_000913.3
WP_000130850.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75138; AAC75138; b2077
BAA15933; BAA15933; BAA15933
GeneIDi946601
KEGGiecj:JW2062
eco:b2077
PATRICifig|1411691.4.peg.173

Similar proteinsi

Entry informationi

Entry nameiMDTD_ECOLI
AccessioniPrimary (citable) accession number: P36554
Secondary accession number(s): P76400, Q54A55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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