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Protein

Putative multidrug resistance protein MdtD

Gene

mdtD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2077-MONOMER.
ECOL316407:JW2062-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.26. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug resistance protein MdtD
Gene namesi
Name:mdtD
Synonyms:yegB
Ordered Locus Names:b2077, JW2062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12136. mdtD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11PeriplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 48CytoplasmicSequence analysisAdd BLAST16
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 76PeriplasmicSequence analysis7
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 101CytoplasmicSequence analysis4
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Topological domaini125 – 137PeriplasmicSequence analysisAdd BLAST13
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 164CytoplasmicSequence analysis6
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 196PeriplasmicSequence analysisAdd BLAST11
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 224CytoplasmicSequence analysis7
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 262PeriplasmicSequence analysisAdd BLAST17
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 285CytoplasmicSequence analysis2
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 341PeriplasmicSequence analysisAdd BLAST35
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 395CytoplasmicSequence analysisAdd BLAST33
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 430PeriplasmicSequence analysisAdd BLAST14
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 471CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734061 – 471Putative multidrug resistance protein MdtDAdd BLAST471

Proteomic databases

PaxDbiP36554.
PRIDEiP36554.

Expressioni

Inductioni

Transcriptionally regulated by BaeR.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4260425. 166 interactors.
DIPiDIP-11876N.
IntActiP36554. 1 interactor.
MINTiMINT-1320504.
STRINGi511145.b2077.

Structurei

3D structure databases

ProteinModelPortaliP36554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0R. Bacteria.
ENOG410XNN3. LUCA.
HOGENOMiHOG000193484.
InParanoidiP36554.
KOiK18326.
OMAiALGFFMQ.
PhylomeDBiP36554.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01577. MFS_MdtD. 1 hit.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR023721. Multi-R_MdtD_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMAQSL GESPLHMHMV
60 70 80 90 100
IVSYVLTVAV MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE
110 120 130 140 150
LLLARALQGV GGAMMVPVGR LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG
160 170 180 190 200
PALGGLLVEY ASWHWIFLIN IPVGIIGAIA TLLLMPNYTM QTRRFDLSGF
210 220 230 240 250
LLLAVGMAVL TLALDGSKGT GLSPLTIAGL VAVGVVALVL YLLHARNNNR
260 270 280 290 300
ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
310 320 330 340 350
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL
360 370 380 390 400
GWYYVLPFVL FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL
410 420 430 440 450
SMSIGVTIAG LLLGLFGSQH VSVDSGTTQT VFMYTWLSMA LIIALPAFIF
460 470
ARVPNDTHQN VAISRRKRSA Q
Length:471
Mass (Da):50,901
Last modified:November 1, 1997 - v2
Checksum:iFCAF02AD330B5F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089190 Genomic DNA. Translation: BAC06610.1.
U00096 Genomic DNA. Translation: AAC75138.1.
AP009048 Genomic DNA. Translation: BAA15933.1.
D14054 Genomic DNA. Translation: BAA03139.1.
PIRiD64974.
RefSeqiNP_416581.1. NC_000913.3.
WP_000130850.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75138; AAC75138; b2077.
BAA15933; BAA15933; BAA15933.
GeneIDi946601.
KEGGiecj:JW2062.
eco:b2077.
PATRICi32119487. VBIEscCol129921_2154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089190 Genomic DNA. Translation: BAC06610.1.
U00096 Genomic DNA. Translation: AAC75138.1.
AP009048 Genomic DNA. Translation: BAA15933.1.
D14054 Genomic DNA. Translation: BAA03139.1.
PIRiD64974.
RefSeqiNP_416581.1. NC_000913.3.
WP_000130850.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260425. 166 interactors.
DIPiDIP-11876N.
IntActiP36554. 1 interactor.
MINTiMINT-1320504.
STRINGi511145.b2077.

Protein family/group databases

TCDBi2.A.1.3.26. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP36554.
PRIDEiP36554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75138; AAC75138; b2077.
BAA15933; BAA15933; BAA15933.
GeneIDi946601.
KEGGiecj:JW2062.
eco:b2077.
PATRICi32119487. VBIEscCol129921_2154.

Organism-specific databases

EchoBASEiEB2057.
EcoGeneiEG12136. mdtD.

Phylogenomic databases

eggNOGiENOG4105C0R. Bacteria.
ENOG410XNN3. LUCA.
HOGENOMiHOG000193484.
InParanoidiP36554.
KOiK18326.
OMAiALGFFMQ.
PhylomeDBiP36554.

Enzyme and pathway databases

BioCyciEcoCyc:B2077-MONOMER.
ECOL316407:JW2062-MONOMER.

Miscellaneous databases

PROiP36554.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01577. MFS_MdtD. 1 hit.
InterProiIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR023721. Multi-R_MdtD_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00711. efflux_EmrB. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTD_ECOLI
AccessioniPrimary (citable) accession number: P36554
Secondary accession number(s): P76400, Q54A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.