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Protein

N-acetylmuramoyl-L-alanine amidase CwlL

Gene

cwlL

Organism
Bacillus licheniformis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase CwlL (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:cwlL
OrganismiBacillus licheniformis
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939By similarityAdd
BLAST
Chaini40 – 360321N-acetylmuramoyl-L-alanine amidase CwlLPRO_0000006455Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP36550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati166 – 191261-1Add
BLAST
Repeati196 – 259642-1Add
BLAST
Repeati265 – 289251-2Add
BLAST
Repeati291 – 355652-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 2891242 X approximate repeatsAdd
BLAST
Regioni196 – 3551602 X approximate repeatsAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di1.10.101.10. 2 hits.
3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 2 hits.
SSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36550-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKVVKNFVK VNQYTRPGLK LAGVKGIVMH YTATPGASAL NERDYFNGTC
60 70 80 90 100
IAIKRKASSA HYFVDRKEAQ HIIPENEVAY HAHDKNRCYV SFLKPNANTK
110 120 130 140 150
SISVEMCVEK DGMIHSETVQ NAAELVADLC KRYGLSTNKI VRHYDVTNKI
160 170 180 190 200
CPAPWVSDSS QLTTFRKKVD SLLGNKTVSK TTSSTSQSSK STGTILKKGA
210 220 230 240 250
SGSQVKALQK RLIAAGFSLP KYGADGSYEN ETVQAVKALQ KKAGIAVDGI
260 270 280 290 300
YGPATEKALA AIGAKKKKPS SNGKKTSYPL PSGIYKVKSP LMKGTGVRQI
310 320 330 340 350
QEALAALYFY PDKGAKNNGI DGYYGPKTAN AVKRFQLMHG LSADGIYGSD
360
TKAKLKTLLK
Length:360
Mass (Da):38,996
Last modified:June 1, 1994 - v1
Checksum:i37C07B4A084364DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13377 Genomic DNA. Translation: BAA02647.1.
PIRiS39916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13377 Genomic DNA. Translation: BAA02647.1.
PIRiS39916.

3D structure databases

ProteinModelPortaliP36550.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.101.10. 2 hits.
3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 2 hits.
SSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, sequence analysis, and characterization of a new cell wall hydrolase, CwlL, of Bacillus licheniformis."
    Oda Y., Nakayama R., Kuroda A., Sekiguchi J.
    Mol. Gen. Genet. 241:380-388(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FD0120.

Entry informationi

Entry nameiCWLL_BACLI
AccessioniPrimary (citable) accession number: P36550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.