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Protein

HTH-type transcriptional regulator eutR

Gene

eutR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 278H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12190-MONOMER.
ECOL316407:JW2430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator eutR
Alternative name(s):
Ethanolamine operon regulatory protein
Gene namesi
Name:eutR
Synonyms:yfeG
Ordered Locus Names:b2437, JW2430
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12190. eutR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945091 – 350HTH-type transcriptional regulator eutRAdd BLAST350

Proteomic databases

PaxDbiP36547.
PRIDEiP36547.

Interactioni

Protein-protein interaction databases

IntActiP36547. 3 interactors.
STRINGi511145.b2437.

Structurei

3D structure databases

ProteinModelPortaliP36547.
SMRiP36547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108K3Z. Bacteria.
ENOG410ZX7Q. LUCA.
HOGENOMiHOG000117033.
KOiK04033.
OMAiFLHHPER.
PhylomeDBiP36547.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTRTANLH HLYHEPLPEN LKLTPKVEVD NVHQRQTTDV YEHALTITAW
60 70 80 90 100
QQIYDQLHPG KFHGEFTEIL LDDIQVFREY TGLALRQSCL VWPNSFWFGI
110 120 130 140 150
PATRGEQGFI GSQCLGSAEI ATRPGGTEFE LSTPDDYTIL GVVLSEDVIT
160 170 180 190 200
RQANFLHNPD RVLHMLRNQS ALEVKEQHKA ALWGFVQQAL ATFCENPENL
210 220 230 240 250
HQPAVRKVLG DNLLMAMGAM LEEAQPMVTA ESISHQSYRR LLSRAREYVL
260 270 280 290 300
ENMSEPVTVL DLCNQLHVSR RTLQNAFHAI LGIGPNAWLK RIRLNAVRRE
310 320 330 340 350
LISPWSQSMT VKDAAMQWGF WHLGQFATDY QQLFSEKPSL TLHQRMREWG
Length:350
Mass (Da):40,160
Last modified:November 1, 1997 - v2
Checksum:i1281A43DC31DE845
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276A → R in CAA53168 (PubMed:8300522).Curated1
Sequence conflicti285P → R in CAA53168 (PubMed:8300522).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75413 Genomic DNA. Translation: CAA53168.1.
U00096 Genomic DNA. Translation: AAC75490.1.
AP009048 Genomic DNA. Translation: BAA16320.1.
PIRiD65018.
RefSeqiNP_416932.1. NC_000913.3.
WP_000753690.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75490; AAC75490; b2437.
BAA16320; BAA16320; BAA16320.
GeneIDi946911.
KEGGiecj:JW2430.
eco:b2437.
PATRICi32120259. VBIEscCol129921_2532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75413 Genomic DNA. Translation: CAA53168.1.
U00096 Genomic DNA. Translation: AAC75490.1.
AP009048 Genomic DNA. Translation: BAA16320.1.
PIRiD65018.
RefSeqiNP_416932.1. NC_000913.3.
WP_000753690.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP36547.
SMRiP36547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP36547. 3 interactors.
STRINGi511145.b2437.

Proteomic databases

PaxDbiP36547.
PRIDEiP36547.

Protocols and materials databases

DNASUi946911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75490; AAC75490; b2437.
BAA16320; BAA16320; BAA16320.
GeneIDi946911.
KEGGiecj:JW2430.
eco:b2437.
PATRICi32120259. VBIEscCol129921_2532.

Organism-specific databases

EchoBASEiEB2107.
EcoGeneiEG12190. eutR.

Phylogenomic databases

eggNOGiENOG4108K3Z. Bacteria.
ENOG410ZX7Q. LUCA.
HOGENOMiHOG000117033.
KOiK04033.
OMAiFLHHPER.
PhylomeDBiP36547.

Enzyme and pathway databases

BioCyciEcoCyc:EG12190-MONOMER.
ECOL316407:JW2430-MONOMER.

Miscellaneous databases

PROiP36547.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEUTR_ECOLI
AccessioniPrimary (citable) accession number: P36547
Secondary accession number(s): P77451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.