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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

CHRNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: UniProtKB
  • acetylcholine binding Source: UniProtKB
  • acetylcholine-gated cation channel activity Source: ParkinsonsUK-UCL
  • acetylcholine receptor activity Source: UniProtKB
  • beta-amyloid binding Source: UniProtKB
  • chloride channel regulator activity Source: UniProtKB
  • ligand-gated ion channel activity Source: Reactome
  • protein homodimerization activity Source: UniProtKB
  • toxic substance binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • cognition Source: UniProtKB
  • ion transmembrane transport Source: ParkinsonsUK-UCL
  • ion transport Source: UniProtKB
  • memory Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to nicotine Source: UniProtKB
  • signal transduction Source: UniProtKB
  • synaptic transmission, cholinergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175344-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinkiP36544.
SIGNORiP36544.

Protein family/group databases

TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:CHRNA7
Synonyms:NACHRA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1960. CHRNA7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 230ExtracellularSequence analysisAdd BLAST208
Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei296 – 317HelicalSequence analysisAdd BLAST22
Topological domaini318 – 469CytoplasmicSequence analysisAdd BLAST152
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi1139.
89832.
MalaCardsiCHRNA7.
OpenTargetsiENSG00000175344.
ENSG00000274542.
ENSG00000282088.
Orphaneti199318. 15q13.3 microdeletion syndrome.
PharmGKBiPA114.
PA26483.

Chemistry databases

ChEMBLiCHEMBL2492.
DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB09028. Cytisine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00674. Galantamine.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00184. Nicotine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi468.

Polymorphism and mutation databases

BioMutaiCHRNA7.
DMDMi2506127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000036623 – 502Neuronal acetylcholine receptor subunit alpha-7Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36544.
PRIDEiP36544.

PTM databases

iPTMnetiP36544.
PhosphoSitePlusiP36544.
SwissPalmiP36544.

Expressioni

Gene expression databases

BgeeiENSG00000175344.
CleanExiHS_CHRNA7.
ExpressionAtlasiP36544. baseline and differential.
GenevisibleiP36544. HS.

Organism-specific databases

HPAiCAB033624.
HPA029422.

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107561. 3 interactors.
IntActiP36544. 2 interactors.
STRINGi9606.ENSP00000299847.

Chemistry databases

BindingDBiP36544.

Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 34Combined sources11
Beta strandi51 – 66Combined sources16
Turni67 – 70Combined sources4
Beta strandi71 – 83Combined sources13
Helixi85 – 87Combined sources3
Turni91 – 93Combined sources3
Beta strandi94 – 96Combined sources3
Beta strandi99 – 103Combined sources5
Helixi104 – 106Combined sources3
Beta strandi112 – 114Combined sources3
Beta strandi118 – 120Combined sources3
Beta strandi129 – 133Combined sources5
Beta strandi137 – 140Combined sources4
Beta strandi143 – 149Combined sources7
Beta strandi158 – 160Combined sources3
Beta strandi162 – 172Combined sources11
Turni175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Beta strandi194 – 208Combined sources15
Beta strandi211 – 215Combined sources5
Beta strandi217 – 227Combined sources11
Helixi229 – 253Combined sources25
Helixi260 – 282Combined sources23
Beta strandi286 – 288Combined sources3
Helixi293 – 317Combined sources25
Beta strandi324 – 326Combined sources3
Helixi467 – 489Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
5AFHX-ray2.40A/B/C/D/E23-227[»]
5AFJX-ray2.20A/B/C/D/E23-227[»]
5AFKX-ray2.38A/B/C/D/E23-227[»]
5AFLX-ray2.38A/B/C/D/E23-227[»]
5AFMX-ray2.85A/B/C/D/E23-38[»]
A/B/C/D/E52-71[»]
A/B/C/D/E77-98[»]
A/C/D/E23-192[»]
A/C/D/E96-227[»]
B131-141[»]
B164-168[»]
B178-192[»]
5AFNX-ray2.15A/B/C/D/E23-227[»]
ProteinModelPortaliP36544.
SMRiP36544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP36544.
KOiK04809.
OMAiFPQPHSL.
OrthoDBiEOG091G0R20.
PhylomeDBiP36544.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36544-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG
210 220 230 240 250
IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT
410 420 430 440 450
PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,449
Last modified:November 1, 1997 - v5
Checksum:iD94B3A482EAA0E42
GO
Isoform 2 (identifier: P36544-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: H → HGKATASPPSTPPWDPGHIPGASVRPAPGP

Note: No experimental confirmation available.
Show »
Length:531
Mass (Da):59,235
Checksum:i824BAFD78601D1FD
GO
Isoform 3 (identifier: P36544-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-102: SWTDHYLQWNVSEYPGVKTVRF → AYSRVPATSMYAGFPLMCSTAN
     103-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:102
Mass (Da):11,485
Checksum:i7A5F2F181F009A9E
GO

Sequence cautioni

The sequence AAH37571 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → G in CAA49778 (PubMed:8145738).Curated1
Sequence conflicti58S → N in AAA83561 (Ref. 2) Curated1
Sequence conflicti58S → N in AAK68111 (Ref. 6) Curated1
Sequence conflicti134S → P in AAA83561 (Ref. 2) Curated1
Sequence conflicti134S → P in AAK68111 (Ref. 6) Curated1
Sequence conflicti364C → S in CAA80672 (PubMed:8188270).Curated1
Sequence conflicti375A → G in CAA49778 (PubMed:8145738).Curated1
Sequence conflicti409 – 413RMACS → AWPAP in CAA80672 (PubMed:8188270).Curated5

Mass spectrometryi

Molecular mass is 54157.68 Da from positions 23 - 502. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04301918H → HGKATASPPSTPPWDPGHIP GASVRPAPGP in isoform 2. 1 Publication1
Alternative sequenceiVSP_05810781 – 102SWTDH…KTVRF → AYSRVPATSMYAGFPLMCST AN in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_058108103 – 502Missing in isoform 3. 1 PublicationAdd BLAST400

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1.
U40583 mRNA. Translation: AAA83561.1.
U62436 mRNA. Translation: AAB40114.1.
Y08420 mRNA. Translation: CAA69697.1.
AF385585 mRNA. Translation: AAK68111.1.
AK292069 mRNA. Translation: BAF84758.1.
AK294229 mRNA. Translation: BAG57531.1.
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1. Sequence problems.
BC101345 mRNA. Translation: AAI01346.1.
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1.
AF332758 Genomic DNA. Translation: AAK19515.1.
CCDSiCCDS10027.1. [P36544-1]
CCDS53924.1. [P36544-2]
PIRiG02259.
I37185. ACHUA7.
RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
NP_001177384.1. NM_001190455.2. [P36544-2]
NP_683709.1. NM_148911.1.
XP_005254807.1. XM_005254750.2.
XP_016877373.1. XM_017021884.1.
UniGeneiHs.510853.
Hs.511772.
Hs.713151.

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
ENST00000437966; ENSP00000399087; ENSG00000175344. [P36544-3]
ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
GeneIDi1139.
89832.
KEGGihsa:1139.
UCSCiuc001zft.5. human. [P36544-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1.
U40583 mRNA. Translation: AAA83561.1.
U62436 mRNA. Translation: AAB40114.1.
Y08420 mRNA. Translation: CAA69697.1.
AF385585 mRNA. Translation: AAK68111.1.
AK292069 mRNA. Translation: BAF84758.1.
AK294229 mRNA. Translation: BAG57531.1.
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1. Sequence problems.
BC101345 mRNA. Translation: AAI01346.1.
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1.
AF332758 Genomic DNA. Translation: AAK19515.1.
CCDSiCCDS10027.1. [P36544-1]
CCDS53924.1. [P36544-2]
PIRiG02259.
I37185. ACHUA7.
RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
NP_001177384.1. NM_001190455.2. [P36544-2]
NP_683709.1. NM_148911.1.
XP_005254807.1. XM_005254750.2.
XP_016877373.1. XM_017021884.1.
UniGeneiHs.510853.
Hs.511772.
Hs.713151.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
5AFHX-ray2.40A/B/C/D/E23-227[»]
5AFJX-ray2.20A/B/C/D/E23-227[»]
5AFKX-ray2.38A/B/C/D/E23-227[»]
5AFLX-ray2.38A/B/C/D/E23-227[»]
5AFMX-ray2.85A/B/C/D/E23-38[»]
A/B/C/D/E52-71[»]
A/B/C/D/E77-98[»]
A/C/D/E23-192[»]
A/C/D/E96-227[»]
B131-141[»]
B164-168[»]
B178-192[»]
5AFNX-ray2.15A/B/C/D/E23-227[»]
ProteinModelPortaliP36544.
SMRiP36544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107561. 3 interactors.
IntActiP36544. 2 interactors.
STRINGi9606.ENSP00000299847.

Chemistry databases

BindingDBiP36544.
ChEMBLiCHEMBL2492.
DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB09028. Cytisine.
DB00514. Dextromethorphan.
DB00898. Ethanol.
DB00674. Galantamine.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00184. Nicotine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi468.

Protein family/group databases

TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

iPTMnetiP36544.
PhosphoSitePlusiP36544.
SwissPalmiP36544.

Polymorphism and mutation databases

BioMutaiCHRNA7.
DMDMi2506127.

Proteomic databases

PaxDbiP36544.
PRIDEiP36544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
ENST00000437966; ENSP00000399087; ENSG00000175344. [P36544-3]
ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
GeneIDi1139.
89832.
KEGGihsa:1139.
UCSCiuc001zft.5. human. [P36544-1]

Organism-specific databases

CTDi1139.
89832.
DisGeNETi1139.
89832.
GeneCardsiCHRNA7.
HGNCiHGNC:1960. CHRNA7.
HPAiCAB033624.
HPA029422.
MalaCardsiCHRNA7.
MIMi118511. gene.
neXtProtiNX_P36544.
OpenTargetsiENSG00000175344.
ENSG00000274542.
ENSG00000282088.
Orphaneti199318. 15q13.3 microdeletion syndrome.
PharmGKBiPA114.
PA26483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP36544.
KOiK04809.
OMAiFPQPHSL.
OrthoDBiEOG091G0R20.
PhylomeDBiP36544.
TreeFamiTF315605.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175344-MONOMER.
ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinkiP36544.
SIGNORiP36544.

Miscellaneous databases

ChiTaRSiCHRNA7. human.
GeneWikiiCHRFAM7A.
CHRNA7.
PROiP36544.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175344.
CleanExiHS_CHRNA7.
ExpressionAtlasiP36544. baseline and differential.
GenevisibleiP36544. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA7_HUMAN
AccessioniPrimary (citable) accession number: P36544
Secondary accession number(s): A8K7Q4
, B4DFS0, Q15826, Q8IUZ4, Q96RH2, Q99555, Q9BXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 177 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.