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P36544

- ACHA7_HUMAN

UniProt

P36544 - ACHA7_HUMAN

Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

CHRNA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 5 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: UniProtKB
    2. acetylcholine binding Source: UniProtKB
    3. acetylcholine-gated cation channel activity Source: ParkinsonsUK-UCL
    4. acetylcholine receptor activity Source: UniProtKB
    5. beta-amyloid binding Source: UniProtKB
    6. chloride channel regulator activity Source: UniProtKB
    7. drug binding Source: Ensembl
    8. protein homodimerization activity Source: UniProtKB
    9. toxic substance binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. associative learning Source: Ensembl
    3. B cell activation Source: Ensembl
    4. behavioral response to ethanol Source: Ensembl
    5. behavioral response to nicotine Source: Ensembl
    6. calcium ion transport Source: UniProtKB
    7. cellular calcium ion homeostasis Source: UniProtKB
    8. cognition Source: UniProtKB
    9. dopamine biosynthetic process Source: Ensembl
    10. endocytosis Source: Ensembl
    11. generation of ovulation cycle rhythm Source: Ensembl
    12. ion transmembrane transport Source: ParkinsonsUK-UCL
    13. ion transport Source: UniProtKB
    14. memory Source: UniProtKB
    15. negative regulation of inflammatory response Source: Ensembl
    16. negative regulation of interleukin-1 beta production Source: Ensembl
    17. negative regulation of interleukin-6 production Source: Ensembl
    18. negative regulation of tumor necrosis factor production Source: UniProtKB
    19. neuronal action potential Source: Ensembl
    20. positive regulation of angiogenesis Source: UniProtKB
    21. positive regulation of cell proliferation Source: UniProtKB
    22. positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure Source: Ensembl
    23. regulation of norepinephrine secretion Source: Ensembl
    24. regulation of synaptic transmission, dopaminergic Source: Ensembl
    25. response to food Source: Ensembl
    26. response to hypoxia Source: UniProtKB
    27. response to nicotine Source: UniProtKB
    28. signal transduction Source: UniProtKB
    29. sperm motility Source: Ensembl
    30. synaptic transmission Source: Reactome
    31. synaptic transmission, cholinergic Source: Ensembl
    32. T cell activation Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    SignaLinkiP36544.

    Protein family/group databases

    TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-7
    Gene namesi
    Name:CHRNA7
    Synonyms:NACHRA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1960. CHRNA7.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: UniProtKB
    2. apical plasma membrane Source: Ensembl
    3. asymmetric synapse Source: Ensembl
    4. axon Source: Ensembl
    5. cell junction Source: UniProtKB-KW
    6. cytoplasm Source: Ensembl
    7. dendritic shaft Source: Ensembl
    8. dendritic spine Source: Ensembl
    9. external side of plasma membrane Source: Ensembl
    10. growth cone Source: Ensembl
    11. integral component of membrane Source: UniProtKB
    12. membrane raft Source: Ensembl
    13. neuronal cell body Source: Ensembl
    14. plasma membrane Source: UniProtKB
    15. postsynaptic density Source: Ensembl
    16. postsynaptic membrane Source: UniProtKB-SubCell
    17. presynaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti199318. 15q13.3 microdeletion syndrome.
    PharmGKBiPA114.
    PA26483.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 502480Neuronal acetylcholine receptor subunit alpha-7PRO_0000000366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 164By similarity
    Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP36544.
    PRIDEiP36544.

    PTM databases

    PhosphoSiteiP36544.

    Expressioni

    Gene expression databases

    ArrayExpressiP36544.
    BgeeiP36544.
    CleanExiHS_CHRNA7.
    GenevestigatoriP36544.

    Organism-specific databases

    HPAiCAB033624.
    HPA029422.

    Interactioni

    Subunit structurei

    Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

    Protein-protein interaction databases

    BioGridi107561. 3 interactions.
    IntActiP36544. 2 interactions.
    STRINGi9606.ENSP00000303727.

    Structurei

    Secondary structure

    1
    502
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi229 – 25325
    Helixi260 – 28223
    Beta strandi286 – 2883
    Helixi293 – 31725
    Beta strandi324 – 3263
    Helixi467 – 48923

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MAWNMR-A228-326[»]
    A467-495[»]
    ProteinModelPortaliP36544.
    SMRiP36544. Positions 24-323, 467-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 230208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 469152CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei231 – 25525HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235631.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiP36544.
    KOiK04809.
    OMAiESEAICS.
    OrthoDBiEOG72JWGV.
    PhylomeDBiP36544.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P36544-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP    50
    LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV 100
    RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC 150
    YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG 200
    IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL 250
    VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST 300
    MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE 350
    DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT 400
    PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ 450
    DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD 500
    FA 502
    Length:502
    Mass (Da):56,449
    Last modified:November 1, 1997 - v5
    Checksum:iD94B3A482EAA0E42
    GO
    Isoform 2 (identifier: P36544-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-18: H → HGKATASPPSTPPWDPGHIPGASVRPAPGP

    Note: No experimental confirmation available.

    Show »
    Length:531
    Mass (Da):59,235
    Checksum:i824BAFD78601D1FD
    GO
    Isoform 3 (identifier: P36544-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-181: Missing.

    Show »
    Length:321
    Mass (Da):35,482
    Checksum:i2998C11DD1F15A89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111A → G in CAA49778. (PubMed:8145738)Curated
    Sequence conflicti58 – 581S → N in AAA83561. 1 PublicationCurated
    Sequence conflicti58 – 581S → N in AAK68111. 1 PublicationCurated
    Sequence conflicti134 – 1341S → P in AAA83561. 1 PublicationCurated
    Sequence conflicti134 – 1341S → P in AAK68111. 1 PublicationCurated
    Sequence conflicti364 – 3641C → S in CAA80672. (PubMed:8188270)Curated
    Sequence conflicti375 – 3751A → G in CAA49778. (PubMed:8145738)Curated
    Sequence conflicti409 – 4135RMACS → AWPAP in CAA80672. (PubMed:8188270)Curated

    Mass spectrometryi

    Molecular mass is 54157.68 Da from positions 23 - 502. Determined by MALDI. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 181181Missing in isoform 3. 1 PublicationVSP_044268Add
    BLAST
    Alternative sequencei18 – 181H → HGKATASPPSTPPWDPGHIP GASVRPAPGP in isoform 2. 1 PublicationVSP_043019

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70297 mRNA. Translation: CAA49778.1.
    U40583 mRNA. Translation: AAA83561.1.
    U62436 mRNA. Translation: AAB40114.1.
    Y08420 mRNA. Translation: CAA69697.1.
    AF385585 mRNA. Translation: AAK68111.1.
    AK292069 mRNA. Translation: BAF84758.1.
    AK294229 mRNA. Translation: BAG57531.1.
    AC004460 Genomic DNA. No translation available.
    AC009562 Genomic DNA. No translation available.
    AC012236 Genomic DNA. No translation available.
    AC021316 Genomic DNA. No translation available.
    AC026150 Genomic DNA. No translation available.
    AC026951 Genomic DNA. No translation available.
    AC058803 Genomic DNA. No translation available.
    AC068448 Genomic DNA. No translation available.
    AC079969 Genomic DNA. No translation available.
    AC087481 Genomic DNA. No translation available.
    AC090829 Genomic DNA. No translation available.
    AC091057 Genomic DNA. No translation available.
    AC104266 Genomic DNA. No translation available.
    AC104759 Genomic DNA. No translation available.
    BC037571 mRNA. Translation: AAH37571.1.
    BC101345 mRNA. Translation: AAI01346.1.
    L25827 mRNA. No translation available.
    Z23141 mRNA. Translation: CAA80672.1.
    AF332758 Genomic DNA. Translation: AAK19515.1.
    CCDSiCCDS10027.1. [P36544-1]
    CCDS53924.1. [P36544-2]
    PIRiG02259.
    I37185. ACHUA7.
    RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
    NP_001177384.1. NM_001190455.2. [P36544-2]
    NP_683709.1. NM_148911.1. [P36544-3]
    XP_005254807.1. XM_005254750.1. [P36544-3]
    UniGeneiHs.510853.
    Hs.511772.
    Hs.713151.

    Genome annotation databases

    EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
    ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
    GeneIDi1139.
    89832.
    KEGGihsa:1139.
    hsa:89832.
    UCSCiuc001zft.4. human. [P36544-1]
    uc021sic.2. human. [P36544-2]

    Polymorphism databases

    DMDMi2506127.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70297 mRNA. Translation: CAA49778.1 .
    U40583 mRNA. Translation: AAA83561.1 .
    U62436 mRNA. Translation: AAB40114.1 .
    Y08420 mRNA. Translation: CAA69697.1 .
    AF385585 mRNA. Translation: AAK68111.1 .
    AK292069 mRNA. Translation: BAF84758.1 .
    AK294229 mRNA. Translation: BAG57531.1 .
    AC004460 Genomic DNA. No translation available.
    AC009562 Genomic DNA. No translation available.
    AC012236 Genomic DNA. No translation available.
    AC021316 Genomic DNA. No translation available.
    AC026150 Genomic DNA. No translation available.
    AC026951 Genomic DNA. No translation available.
    AC058803 Genomic DNA. No translation available.
    AC068448 Genomic DNA. No translation available.
    AC079969 Genomic DNA. No translation available.
    AC087481 Genomic DNA. No translation available.
    AC090829 Genomic DNA. No translation available.
    AC091057 Genomic DNA. No translation available.
    AC104266 Genomic DNA. No translation available.
    AC104759 Genomic DNA. No translation available.
    BC037571 mRNA. Translation: AAH37571.1 .
    BC101345 mRNA. Translation: AAI01346.1 .
    L25827 mRNA. No translation available.
    Z23141 mRNA. Translation: CAA80672.1 .
    AF332758 Genomic DNA. Translation: AAK19515.1 .
    CCDSi CCDS10027.1. [P36544-1 ]
    CCDS53924.1. [P36544-2 ]
    PIRi G02259.
    I37185. ACHUA7.
    RefSeqi NP_000737.1. NM_000746.5. [P36544-1 ]
    NP_001177384.1. NM_001190455.2. [P36544-2 ]
    NP_683709.1. NM_148911.1. [P36544-3 ]
    XP_005254807.1. XM_005254750.1. [P36544-3 ]
    UniGenei Hs.510853.
    Hs.511772.
    Hs.713151.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MAW NMR - A 228-326 [» ]
    A 467-495 [» ]
    ProteinModelPortali P36544.
    SMRi P36544. Positions 24-323, 467-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107561. 3 interactions.
    IntActi P36544. 2 interactions.
    STRINGi 9606.ENSP00000303727.

    Chemistry

    BindingDBi P36544.
    ChEMBLi CHEMBL2492.
    DrugBanki DB01351. Amobarbital.
    DB01352. Aprobarbital.
    DB00237. Butabarbital.
    DB00241. Butalbital.
    DB01353. Butethal.
    DB00514. Dextromethorphan.
    DB00674. Galantamine.
    DB01354. Heptabarbital.
    DB01355. Hexobarbital.
    DB00849. Methylphenobarbital.
    DB00184. Nicotine.
    DB00312. Pentobarbital.
    DB01174. Phenobarbital.
    DB00794. Primidone.
    DB00418. Secobarbital.
    DB00306. Talbutal.
    DB00599. Thiopental.
    DB01273. Varenicline.
    GuidetoPHARMACOLOGYi 468.

    Protein family/group databases

    TCDBi 1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    PTM databases

    PhosphoSitei P36544.

    Polymorphism databases

    DMDMi 2506127.

    Proteomic databases

    PaxDbi P36544.
    PRIDEi P36544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306901 ; ENSP00000303727 ; ENSG00000175344 . [P36544-1 ]
    ENST00000454250 ; ENSP00000407546 ; ENSG00000175344 . [P36544-2 ]
    GeneIDi 1139.
    89832.
    KEGGi hsa:1139.
    hsa:89832.
    UCSCi uc001zft.4. human. [P36544-1 ]
    uc021sic.2. human. [P36544-2 ]

    Organism-specific databases

    CTDi 1139.
    89832.
    GeneCardsi GC15P032322.
    HGNCi HGNC:1960. CHRNA7.
    HPAi CAB033624.
    HPA029422.
    MIMi 118511. gene.
    neXtProti NX_P36544.
    Orphaneti 199318. 15q13.3 microdeletion syndrome.
    PharmGKBi PA114.
    PA26483.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235631.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi P36544.
    KOi K04809.
    OMAi ESEAICS.
    OrthoDBi EOG72JWGV.
    PhylomeDBi P36544.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    SignaLinki P36544.

    Miscellaneous databases

    GeneWikii CHRFAM7A.
    CHRNA7.
    NextBioi 4738.
    PROi P36544.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P36544.
    Bgeei P36544.
    CleanExi HS_CHRNA7.
    Genevestigatori P36544.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."
      Peng X., Katz M., Gerzanich V., Anand R., Lindstrom J.
      Mol. Pharmacol. 45:546-554(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Nucleotide sequence and transcript size of the alpha-7 neuronal nicotinic acetylcholine receptor in human postmortem brain."
      Logel J., Drebing C., Barnhart M., Antle C., Leonard S.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    3. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
      Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
      J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
      Groot Kormelink P.J., Luyten W.H.M.L.
      FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Groot Kormelink P.J., Luyten W.H.M.L.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "Cloning cholinergic receptors in human keratinocytes."
      Arredondo J., Grando S.A.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Keratinocyte.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala and Stomach.
    8. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    10. "Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."
      Doucette-Stamm L., Monteggia L.M., Donnelly-Roberts D., Wang M.T., Lee J., Tian J., Giordano T.
      Drug Dev. Res. 30:252-256(1993)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-502 (ISOFORM 1).
      Tissue: Brain.
    11. "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."
      Chini B., Raimondi E., Elgoyhen A.B., Moralli D., Balzaretti M., Heinemann S.F.
      Genomics 19:379-381(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-502 (ISOFORM 1).
      Tissue: Retina.
    12. "A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."
      Riley B., Williamson M., Collier D., Wilkie H., Makoff A.
      Genomics 79:197-209(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-129.
    13. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
      Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J.
      Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
      Tissue: Mammary cancer.
    14. "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."
      Williams M.E., Burton B., Urrutia A., Shcherbatko A., Chavez-Noriega L.E., Cohen C.J., Aiyar J.
      J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIC3.
    15. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
      Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
      Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIC3.

    Entry informationi

    Entry nameiACHA7_HUMAN
    AccessioniPrimary (citable) accession number: P36544
    Secondary accession number(s): A8K7Q4
    , B4DFS0, Q15826, Q8IUZ4, Q96RH2, Q99555, Q9BXH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 154 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3