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P36544

- ACHA7_HUMAN

UniProt

P36544 - ACHA7_HUMAN

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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

CHRNA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: UniProtKB
  2. acetylcholine binding Source: UniProtKB
  3. acetylcholine-gated cation channel activity Source: ParkinsonsUK-UCL
  4. acetylcholine receptor activity Source: UniProtKB
  5. beta-amyloid binding Source: UniProtKB
  6. chloride channel regulator activity Source: UniProtKB
  7. drug binding Source: Ensembl
  8. protein homodimerization activity Source: UniProtKB
  9. toxic substance binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. associative learning Source: Ensembl
  3. B cell activation Source: Ensembl
  4. behavioral response to ethanol Source: Ensembl
  5. behavioral response to nicotine Source: Ensembl
  6. calcium ion transport Source: UniProtKB
  7. cation transmembrane transport Source: GOC
  8. cellular calcium ion homeostasis Source: UniProtKB
  9. cognition Source: UniProtKB
  10. dopamine biosynthetic process Source: Ensembl
  11. endocytosis Source: Ensembl
  12. generation of ovulation cycle rhythm Source: Ensembl
  13. ion transmembrane transport Source: ParkinsonsUK-UCL
  14. ion transport Source: UniProtKB
  15. memory Source: UniProtKB
  16. negative regulation of inflammatory response Source: Ensembl
  17. negative regulation of interleukin-1 beta production Source: Ensembl
  18. negative regulation of interleukin-6 production Source: Ensembl
  19. negative regulation of tumor necrosis factor production Source: UniProtKB
  20. neuronal action potential Source: Ensembl
  21. positive regulation of angiogenesis Source: UniProtKB
  22. positive regulation of cell proliferation Source: UniProtKB
  23. positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure Source: Ensembl
  24. regulation of norepinephrine secretion Source: Ensembl
  25. regulation of synaptic transmission, dopaminergic Source: Ensembl
  26. response to food Source: Ensembl
  27. response to hypoxia Source: UniProtKB
  28. response to nicotine Source: UniProtKB
  29. signal transduction Source: UniProtKB
  30. sperm motility Source: Ensembl
  31. synaptic transmission Source: Reactome
  32. synaptic transmission, cholinergic Source: Ensembl
  33. T cell activation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinkiP36544.

Protein family/group databases

TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:CHRNA7
Synonyms:NACHRA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:1960. CHRNA7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 230208ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25525HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28019HelicalSequence AnalysisAdd
BLAST
Transmembranei296 – 31722HelicalSequence AnalysisAdd
BLAST
Topological domaini318 – 469152CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: UniProtKB
  2. apical plasma membrane Source: Ensembl
  3. asymmetric synapse Source: Ensembl
  4. axon Source: Ensembl
  5. cell junction Source: UniProtKB-KW
  6. cytoplasm Source: Ensembl
  7. dendritic shaft Source: Ensembl
  8. dendritic spine Source: Ensembl
  9. external side of plasma membrane Source: Ensembl
  10. growth cone Source: Ensembl
  11. integral component of membrane Source: UniProtKB
  12. membrane raft Source: Ensembl
  13. neuronal cell body Source: Ensembl
  14. plasma membrane Source: UniProtKB
  15. postsynaptic density Source: Ensembl
  16. postsynaptic membrane Source: UniProtKB-KW
  17. presynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

Orphaneti199318. 15q13.3 microdeletion syndrome.
PharmGKBiPA114.
PA26483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 502480Neuronal acetylcholine receptor subunit alpha-7PRO_0000000366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36544.
PRIDEiP36544.

PTM databases

PhosphoSiteiP36544.

Expressioni

Gene expression databases

BgeeiP36544.
CleanExiHS_CHRNA7.
ExpressionAtlasiP36544. baseline.
GenevestigatoriP36544.

Organism-specific databases

HPAiCAB033624.
HPA029422.

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

Protein-protein interaction databases

BioGridi107561. 3 interactions.
IntActiP36544. 2 interactions.
STRINGi9606.ENSP00000303727.

Structurei

Secondary structure

1
502
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi229 – 25325Combined sources
Helixi260 – 28223Combined sources
Beta strandi286 – 2883Combined sources
Helixi293 – 31725Combined sources
Beta strandi324 – 3263Combined sources
Helixi467 – 48923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
ProteinModelPortaliP36544.
SMRiP36544. Positions 23-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235631.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP36544.
KOiK04809.
OMAiESEAICS.
OrthoDBiEOG72JWGV.
PhylomeDBiP36544.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P36544-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG
210 220 230 240 250
IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT
410 420 430 440 450
PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,449
Last modified:November 1, 1997 - v5
Checksum:iD94B3A482EAA0E42
GO
Isoform 2 (identifier: P36544-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: H → HGKATASPPSTPPWDPGHIPGASVRPAPGP

Note: No experimental confirmation available.

Show »
Length:531
Mass (Da):59,235
Checksum:i824BAFD78601D1FD
GO
Isoform 3 (identifier: P36544-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Show »
Length:321
Mass (Da):35,482
Checksum:i2998C11DD1F15A89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111A → G in CAA49778. (PubMed:8145738)Curated
Sequence conflicti58 – 581S → N in AAA83561. 1 PublicationCurated
Sequence conflicti58 – 581S → N in AAK68111. 1 PublicationCurated
Sequence conflicti134 – 1341S → P in AAA83561. 1 PublicationCurated
Sequence conflicti134 – 1341S → P in AAK68111. 1 PublicationCurated
Sequence conflicti364 – 3641C → S in CAA80672. (PubMed:8188270)Curated
Sequence conflicti375 – 3751A → G in CAA49778. (PubMed:8145738)Curated
Sequence conflicti409 – 4135RMACS → AWPAP in CAA80672. (PubMed:8188270)Curated

Mass spectrometryi

Molecular mass is 54157.68 Da from positions 23 - 502. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform 3. 1 PublicationVSP_044268Add
BLAST
Alternative sequencei18 – 181H → HGKATASPPSTPPWDPGHIP GASVRPAPGP in isoform 2. 1 PublicationVSP_043019

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1.
U40583 mRNA. Translation: AAA83561.1.
U62436 mRNA. Translation: AAB40114.1.
Y08420 mRNA. Translation: CAA69697.1.
AF385585 mRNA. Translation: AAK68111.1.
AK292069 mRNA. Translation: BAF84758.1.
AK294229 mRNA. Translation: BAG57531.1.
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1.
BC101345 mRNA. Translation: AAI01346.1.
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1.
AF332758 Genomic DNA. Translation: AAK19515.1.
CCDSiCCDS10027.1. [P36544-1]
CCDS53924.1. [P36544-2]
PIRiG02259.
I37185. ACHUA7.
RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
NP_001177384.1. NM_001190455.2. [P36544-2]
NP_683709.1. NM_148911.1. [P36544-3]
XP_005254807.1. XM_005254750.1. [P36544-3]
UniGeneiHs.510853.
Hs.511772.
Hs.713151.

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
ENST00000455693; ENSP00000405989; ENSG00000274542. [P36544-1]
GeneIDi1139.
89832.
KEGGihsa:1139.
hsa:89832.
UCSCiuc001zft.4. human. [P36544-1]
uc021sic.2. human. [P36544-2]

Polymorphism databases

DMDMi2506127.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1 .
U40583 mRNA. Translation: AAA83561.1 .
U62436 mRNA. Translation: AAB40114.1 .
Y08420 mRNA. Translation: CAA69697.1 .
AF385585 mRNA. Translation: AAK68111.1 .
AK292069 mRNA. Translation: BAF84758.1 .
AK294229 mRNA. Translation: BAG57531.1 .
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1 .
BC101345 mRNA. Translation: AAI01346.1 .
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1 .
AF332758 Genomic DNA. Translation: AAK19515.1 .
CCDSi CCDS10027.1. [P36544-1 ]
CCDS53924.1. [P36544-2 ]
PIRi G02259.
I37185. ACHUA7.
RefSeqi NP_000737.1. NM_000746.5. [P36544-1 ]
NP_001177384.1. NM_001190455.2. [P36544-2 ]
NP_683709.1. NM_148911.1. [P36544-3 ]
XP_005254807.1. XM_005254750.1. [P36544-3 ]
UniGenei Hs.510853.
Hs.511772.
Hs.713151.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MAW NMR - A 228-326 [» ]
A 467-495 [» ]
ProteinModelPortali P36544.
SMRi P36544. Positions 23-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107561. 3 interactions.
IntActi P36544. 2 interactions.
STRINGi 9606.ENSP00000303727.

Chemistry

BindingDBi P36544.
ChEMBLi CHEMBL2492.
DrugBanki DB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00514. Dextromethorphan.
DB00674. Galantamine.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00184. Nicotine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi 468.

Protein family/group databases

TCDBi 1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSitei P36544.

Polymorphism databases

DMDMi 2506127.

Proteomic databases

PaxDbi P36544.
PRIDEi P36544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306901 ; ENSP00000303727 ; ENSG00000175344 . [P36544-1 ]
ENST00000454250 ; ENSP00000407546 ; ENSG00000175344 . [P36544-2 ]
ENST00000455693 ; ENSP00000405989 ; ENSG00000274542 . [P36544-1 ]
GeneIDi 1139.
89832.
KEGGi hsa:1139.
hsa:89832.
UCSCi uc001zft.4. human. [P36544-1 ]
uc021sic.2. human. [P36544-2 ]

Organism-specific databases

CTDi 1139.
89832.
GeneCardsi GC15P032322.
HGNCi HGNC:1960. CHRNA7.
HPAi CAB033624.
HPA029422.
MIMi 118511. gene.
neXtProti NX_P36544.
Orphaneti 199318. 15q13.3 microdeletion syndrome.
PharmGKBi PA114.
PA26483.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235631.
GeneTreei ENSGT00760000118930.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi P36544.
KOi K04809.
OMAi ESEAICS.
OrthoDBi EOG72JWGV.
PhylomeDBi P36544.
TreeFami TF315605.

Enzyme and pathway databases

Reactomei REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinki P36544.

Miscellaneous databases

ChiTaRSi CHRNA7. human.
GeneWikii CHRFAM7A.
CHRNA7.
NextBioi 4738.
PROi P36544.
SOURCEi Search...

Gene expression databases

Bgeei P36544.
CleanExi HS_CHRNA7.
ExpressionAtlasi P36544. baseline.
Genevestigatori P36544.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."
    Peng X., Katz M., Gerzanich V., Anand R., Lindstrom J.
    Mol. Pharmacol. 45:546-554(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Nucleotide sequence and transcript size of the alpha-7 neuronal nicotinic acetylcholine receptor in human postmortem brain."
    Logel J., Drebing C., Barnhart M., Antle C., Leonard S.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
    Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
    J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
    Groot Kormelink P.J., Luyten W.H.M.L.
    FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Groot Kormelink P.J., Luyten W.H.M.L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Cloning cholinergic receptors in human keratinocytes."
    Arredondo J., Grando S.A.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Keratinocyte.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Stomach.
  8. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  10. "Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."
    Doucette-Stamm L., Monteggia L.M., Donnelly-Roberts D., Wang M.T., Lee J., Tian J., Giordano T.
    Drug Dev. Res. 30:252-256(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-502 (ISOFORM 1).
    Tissue: Brain.
  11. "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."
    Chini B., Raimondi E., Elgoyhen A.B., Moralli D., Balzaretti M., Heinemann S.F.
    Genomics 19:379-381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-502 (ISOFORM 1).
    Tissue: Retina.
  12. "A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."
    Riley B., Williamson M., Collier D., Wilkie H., Makoff A.
    Genomics 79:197-209(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-129.
  13. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
    Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J.
    Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
    Tissue: Mammary cancer.
  14. "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."
    Williams M.E., Burton B., Urrutia A., Shcherbatko A., Chavez-Noriega L.E., Cohen C.J., Aiyar J.
    J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.
  15. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
    Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
    Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.

Entry informationi

Entry nameiACHA7_HUMAN
AccessioniPrimary (citable) accession number: P36544
Secondary accession number(s): A8K7Q4
, B4DFS0, Q15826, Q8IUZ4, Q96RH2, Q99555, Q9BXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 156 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3