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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

CHRNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: UniProtKB
  • acetylcholine binding Source: UniProtKB
  • acetylcholine-gated cation channel activity Source: ParkinsonsUK-UCL
  • acetylcholine receptor activity Source: UniProtKB
  • beta-amyloid binding Source: UniProtKB
  • chloride channel regulator activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • toxic substance binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • cation transmembrane transport Source: GOC
  • cellular calcium ion homeostasis Source: UniProtKB
  • cognition Source: UniProtKB
  • ion transmembrane transport Source: ParkinsonsUK-UCL
  • ion transport Source: UniProtKB
  • memory Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to nicotine Source: UniProtKB
  • signal transduction Source: UniProtKB
  • synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinkiP36544.

Protein family/group databases

TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:CHRNA7
Synonyms:NACHRA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 15, Unplaced

Organism-specific databases

HGNCiHGNC:1960. CHRNA7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 230208ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25525HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28019HelicalSequence AnalysisAdd
BLAST
Transmembranei296 – 31722HelicalSequence AnalysisAdd
BLAST
Topological domaini318 – 469152CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

Orphaneti199318. 15q13.3 microdeletion syndrome.
PharmGKBiPA114.
PA26483.

Chemistry

DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB09028. Cytisine.
DB00514. Dextromethorphan.
DB00674. Galantamine.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00184. Nicotine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
DB01273. Varenicline.

Polymorphism and mutation databases

BioMutaiCHRNA7.
DMDMi2506127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 502480Neuronal acetylcholine receptor subunit alpha-7PRO_0000000366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP36544.
PRIDEiP36544.

PTM databases

PhosphoSiteiP36544.

Expressioni

Gene expression databases

BgeeiP36544.
CleanExiHS_CHRNA7.
ExpressionAtlasiP36544. baseline.
GenevestigatoriP36544.

Organism-specific databases

HPAiCAB033624.
HPA029422.

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

Protein-protein interaction databases

BioGridi107561. 3 interactions.
IntActiP36544. 2 interactions.
STRINGi9606.ENSP00000303727.

Structurei

Secondary structure

1
502
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi229 – 25325Combined sources
Helixi260 – 28223Combined sources
Beta strandi286 – 2883Combined sources
Helixi293 – 31725Combined sources
Beta strandi324 – 3263Combined sources
Helixi467 – 48923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
ProteinModelPortaliP36544.
SMRiP36544. Positions 24-323, 467-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235631.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP36544.
KOiK04809.
OMAiHRCASAT.
OrthoDBiEOG72JWGV.
PhylomeDBiP36544.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36544-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG
210 220 230 240 250
IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT
410 420 430 440 450
PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,449
Last modified:November 1, 1997 - v5
Checksum:iD94B3A482EAA0E42
GO
Isoform 2 (identifier: P36544-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: H → HGKATASPPSTPPWDPGHIPGASVRPAPGP

Note: No experimental confirmation available.

Show »
Length:531
Mass (Da):59,235
Checksum:i824BAFD78601D1FD
GO
Isoform 3 (identifier: P36544-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Show »
Length:321
Mass (Da):35,482
Checksum:i2998C11DD1F15A89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111A → G in CAA49778 (PubMed:8145738).Curated
Sequence conflicti58 – 581S → N in AAA83561 (Ref. 2) Curated
Sequence conflicti58 – 581S → N in AAK68111 (Ref. 6) Curated
Sequence conflicti134 – 1341S → P in AAA83561 (Ref. 2) Curated
Sequence conflicti134 – 1341S → P in AAK68111 (Ref. 6) Curated
Sequence conflicti364 – 3641C → S in CAA80672 (PubMed:8188270).Curated
Sequence conflicti375 – 3751A → G in CAA49778 (PubMed:8145738).Curated
Sequence conflicti409 – 4135RMACS → AWPAP in CAA80672 (PubMed:8188270).Curated

Mass spectrometryi

Molecular mass is 54157.68 Da from positions 23 - 502. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform 3. 1 PublicationVSP_044268Add
BLAST
Alternative sequencei18 – 181H → HGKATASPPSTPPWDPGHIP GASVRPAPGP in isoform 2. 1 PublicationVSP_043019

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1.
U40583 mRNA. Translation: AAA83561.1.
U62436 mRNA. Translation: AAB40114.1.
Y08420 mRNA. Translation: CAA69697.1.
AF385585 mRNA. Translation: AAK68111.1.
AK292069 mRNA. Translation: BAF84758.1.
AK294229 mRNA. Translation: BAG57531.1.
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1.
BC101345 mRNA. Translation: AAI01346.1.
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1.
AF332758 Genomic DNA. Translation: AAK19515.1.
CCDSiCCDS10027.1. [P36544-1]
CCDS53924.1. [P36544-2]
PIRiG02259.
I37185. ACHUA7.
RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
NP_001177384.1. NM_001190455.2. [P36544-2]
NP_683709.1. NM_148911.1. [P36544-3]
XP_005254807.1. XM_005254750.2. [P36544-3]
UniGeneiHs.510853.
Hs.511772.
Hs.713151.

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
ENST00000455693; ENSP00000405989; ENSG00000274542. [P36544-1]
GeneIDi1139.
89832.
KEGGihsa:1139.
hsa:89832.
UCSCiuc001zft.4. human. [P36544-1]
uc021sic.2. human. [P36544-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA. Translation: CAA49778.1.
U40583 mRNA. Translation: AAA83561.1.
U62436 mRNA. Translation: AAB40114.1.
Y08420 mRNA. Translation: CAA69697.1.
AF385585 mRNA. Translation: AAK68111.1.
AK292069 mRNA. Translation: BAF84758.1.
AK294229 mRNA. Translation: BAG57531.1.
AC004460 Genomic DNA. No translation available.
AC009562 Genomic DNA. No translation available.
AC012236 Genomic DNA. No translation available.
AC021316 Genomic DNA. No translation available.
AC026150 Genomic DNA. No translation available.
AC026951 Genomic DNA. No translation available.
AC058803 Genomic DNA. No translation available.
AC068448 Genomic DNA. No translation available.
AC079969 Genomic DNA. No translation available.
AC087481 Genomic DNA. No translation available.
AC090829 Genomic DNA. No translation available.
AC091057 Genomic DNA. No translation available.
AC104266 Genomic DNA. No translation available.
AC104759 Genomic DNA. No translation available.
BC037571 mRNA. Translation: AAH37571.1.
BC101345 mRNA. Translation: AAI01346.1.
L25827 mRNA. No translation available.
Z23141 mRNA. Translation: CAA80672.1.
AF332758 Genomic DNA. Translation: AAK19515.1.
CCDSiCCDS10027.1. [P36544-1]
CCDS53924.1. [P36544-2]
PIRiG02259.
I37185. ACHUA7.
RefSeqiNP_000737.1. NM_000746.5. [P36544-1]
NP_001177384.1. NM_001190455.2. [P36544-2]
NP_683709.1. NM_148911.1. [P36544-3]
XP_005254807.1. XM_005254750.2. [P36544-3]
UniGeneiHs.510853.
Hs.511772.
Hs.713151.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
ProteinModelPortaliP36544.
SMRiP36544. Positions 24-323, 467-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107561. 3 interactions.
IntActiP36544. 2 interactions.
STRINGi9606.ENSP00000303727.

Chemistry

BindingDBiP36544.
ChEMBLiCHEMBL2492.
DrugBankiDB01351. Amobarbital.
DB01352. Aprobarbital.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB09028. Cytisine.
DB00514. Dextromethorphan.
DB00674. Galantamine.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00849. Methylphenobarbital.
DB00184. Nicotine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00794. Primidone.
DB00418. Secobarbital.
DB00306. Talbutal.
DB00599. Thiopental.
DB01273. Varenicline.
GuidetoPHARMACOLOGYi468.

Protein family/group databases

TCDBi1.A.9.1.7. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSiteiP36544.

Polymorphism and mutation databases

BioMutaiCHRNA7.
DMDMi2506127.

Proteomic databases

PaxDbiP36544.
PRIDEiP36544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344. [P36544-1]
ENST00000454250; ENSP00000407546; ENSG00000175344. [P36544-2]
ENST00000455693; ENSP00000405989; ENSG00000274542. [P36544-1]
GeneIDi1139.
89832.
KEGGihsa:1139.
hsa:89832.
UCSCiuc001zft.4. human. [P36544-1]
uc021sic.2. human. [P36544-2]

Organism-specific databases

CTDi1139.
89832.
GeneCardsiGC15P032322.
HGNCiHGNC:1960. CHRNA7.
HPAiCAB033624.
HPA029422.
MIMi118511. gene.
neXtProtiNX_P36544.
Orphaneti199318. 15q13.3 microdeletion syndrome.
PharmGKBiPA114.
PA26483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG235631.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP36544.
KOiK04809.
OMAiHRCASAT.
OrthoDBiEOG72JWGV.
PhylomeDBiP36544.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiREACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
SignaLinkiP36544.

Miscellaneous databases

ChiTaRSiCHRNA7. human.
GeneWikiiCHRFAM7A.
CHRNA7.
NextBioi4738.
PROiP36544.
SOURCEiSearch...

Gene expression databases

BgeeiP36544.
CleanExiHS_CHRNA7.
ExpressionAtlasiP36544. baseline.
GenevestigatoriP36544.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."
    Peng X., Katz M., Gerzanich V., Anand R., Lindstrom J.
    Mol. Pharmacol. 45:546-554(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Nucleotide sequence and transcript size of the alpha-7 neuronal nicotinic acetylcholine receptor in human postmortem brain."
    Logel J., Drebing C., Barnhart M., Antle C., Leonard S.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
    Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
    J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
    Groot Kormelink P.J., Luyten W.H.M.L.
    FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Groot Kormelink P.J., Luyten W.H.M.L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Cloning cholinergic receptors in human keratinocytes."
    Arredondo J., Grando S.A.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Keratinocyte.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Stomach.
  8. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  10. "Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."
    Doucette-Stamm L., Monteggia L.M., Donnelly-Roberts D., Wang M.T., Lee J., Tian J., Giordano T.
    Drug Dev. Res. 30:252-256(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-502 (ISOFORM 1).
    Tissue: Brain.
  11. "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."
    Chini B., Raimondi E., Elgoyhen A.B., Moralli D., Balzaretti M., Heinemann S.F.
    Genomics 19:379-381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-502 (ISOFORM 1).
    Tissue: Retina.
  12. "A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."
    Riley B., Williamson M., Collier D., Wilkie H., Makoff A.
    Genomics 79:197-209(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-129.
  13. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
    Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J.
    Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
    Tissue: Mammary cancer.
  14. "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."
    Williams M.E., Burton B., Urrutia A., Shcherbatko A., Chavez-Noriega L.E., Cohen C.J., Aiyar J.
    J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.
  15. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
    Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
    Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.

Entry informationi

Entry nameiACHA7_HUMAN
AccessioniPrimary (citable) accession number: P36544
Secondary accession number(s): A8K7Q4
, B4DFS0, Q15826, Q8IUZ4, Q96RH2, Q99555, Q9BXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 160 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.