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Protein

ATP synthase subunit gamma, mitochondrial

Gene

ATP5F1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit gamma, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit gammaImported
F-ATPase gamma subunit
Gene namesi
Name:ATP5F1CImported
Synonyms:ATP5CImported, ATP5C1Imported, ATP5CL1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165629.19
HGNCiHGNC:833 ATP5F1C
MIMi108729 gene
neXtProtiNX_P36542

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi509
OpenTargetsiENSG00000165629
PharmGKBiPA25125

Chemistry databases

DrugBankiDB07384 1-ACETYL-2-CARBOXYPIPERIDINE
DB07394 AUROVERTIN B
DB08399 PICEATANNOL
DB04216 Quercetin

Polymorphism and mutation databases

BioMutaiATP5C1
DMDMi543875

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000268526 – 298ATP synthase subunit gamma, mitochondrialAdd BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei49N6-succinyllysineBy similarity1
Modified residuei55N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysine; alternateBy similarity1
Modified residuei115N6-succinyllysine; alternateBy similarity1
Modified residuei146PhosphoserineCombined sources1
Modified residuei154N6-acetyllysine; alternateCombined sources1
Modified residuei154N6-succinyllysine; alternateBy similarity1
Modified residuei197N6-acetyllysineCombined sources1
Modified residuei270N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP36542
MaxQBiP36542
PaxDbiP36542
PeptideAtlasiP36542
PRIDEiP36542
TopDownProteomicsiP36542-1 [P36542-1]
P36542-2 [P36542-2]

2D gel databases

UCD-2DPAGEiP36542

PTM databases

iPTMnetiP36542
PhosphoSitePlusiP36542
SwissPalmiP36542

Expressioni

Tissue specificityi

Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta.

Gene expression databases

BgeeiENSG00000165629
CleanExiHS_ATP5C1
GenevisibleiP36542 HS

Organism-specific databases

HPAiHPA060949

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi106997, 122 interactors
CORUMiP36542
IntActiP36542, 49 interactors
MINTiP36542
STRINGi9606.ENSP00000349142

Structurei

3D structure databases

ProteinModelPortaliP36542
SMRiP36542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1531 Eukaryota
COG0224 LUCA
GeneTreeiENSGT00390000006837
HOGENOMiHOG000215911
HOVERGENiHBG000933
InParanoidiP36542
KOiK02136
OMAiDRGMCGG
OrthoDBiEOG091G0XX7
PhylomeDBiP36542
TreeFamiTF105765

Family and domain databases

CDDicd12151 F1-ATPase_gamma, 1 hit
InterProiView protein in InterPro
IPR035968 ATP_synth_F1_ATPase_gsu
IPR000131 ATP_synth_F1_gsu
IPR023632 ATP_synth_F1_gsu_CS
PfamiView protein in Pfam
PF00231 ATP-synt, 1 hit
PRINTSiPR00126 ATPASEGAMMA
SUPFAMiSSF52943 SSF52943, 1 hit
TIGRFAMsiTIGR01146 ATPsyn_F1gamma, 1 hit
PROSITEiView protein in PROSITE
PS00153 ATPASE_GAMMA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Liver (identifier: P36542-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM
60 70 80 90 100
VAAAKYARAE RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR
110 120 130 140 150
GLCGAIHSSI AKQMKSEVAT LTAAGKEVML VGIGDKIRGI LYRTHSDQFL
160 170 180 190 200
VAFKEVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNKF RSVISYKTEE
210 220 230 240 250
KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY SLKESTTSEQ
260 270 280 290
SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
Length:298
Mass (Da):32,996
Last modified:June 1, 1994 - v1
Checksum:i021A95168FD53E04
GO
Isoform Heart (identifier: P36542-2) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     298-298: Missing.

Show »
Length:297
Mass (Da):32,881
Checksum:iCA95168FD53E0447
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45T → A in AAH16812 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000439298Missing in isoform Heart. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16561 Genomic DNA Translation: BAA03994.1
D16561 Genomic DNA Translation: BAA03995.1
D16562 mRNA Translation: BAA03996.1
D16563 mRNA Translation: BAA03997.1
AK292896 mRNA Translation: BAF85585.1
CR457403 mRNA Translation: CAG33684.1
AL353754 Genomic DNA No translation available.
AL158044 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86372.1
CH471072 Genomic DNA Translation: EAW86373.1
BC000470 mRNA Translation: AAH00470.1
BC000931 mRNA Translation: AAH00931.1
BC013394 mRNA Translation: AAH13394.1
BC016812 mRNA Translation: AAH16812.1
BC020824 mRNA Translation: AAH20824.1
CCDSiCCDS31142.1 [P36542-1]
CCDS7081.1 [P36542-2]
PIRiA49108
RefSeqiNP_001001973.1, NM_001001973.2 [P36542-1]
NP_005165.1, NM_005174.3 [P36542-2]
UniGeneiHs.271135

Genome annotation databases

EnsembliENST00000335698; ENSP00000338568; ENSG00000165629 [P36542-2]
ENST00000356708; ENSP00000349142; ENSG00000165629 [P36542-1]
GeneIDi509
KEGGihsa:509
UCSCiuc001iju.4 human [P36542-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATPG_HUMAN
AccessioniPrimary (citable) accession number: P36542
Secondary accession number(s): A8KA31
, Q5VYP3, Q6I9V2, Q96AS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health