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Protein

ATP synthase subunit gamma, mitochondrial

Gene

ATP5C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • proton-transporting ATP synthase activity, rotational mechanism Source: InterPro
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • ATP biosynthetic process Source: UniProtKB
  • mitochondrial ATP synthesis coupled proton transport Source: UniProtKB
  • oxidative phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:HS09257-MONOMER.
ReactomeiR-HSA-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit gamma, mitochondrial
Alternative name(s):
F-ATPase gamma subunit
Gene namesi
Name:ATP5C1
Synonyms:ATP5C, ATP5CL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:833. ATP5C1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial matrix Source: Reactome
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi509.
OpenTargetsiENSG00000165629.
PharmGKBiPA25125.

Polymorphism and mutation databases

BioMutaiATP5C1.
DMDMi543875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000268526 – 298ATP synthase subunit gamma, mitochondrialAdd BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei49N6-succinyllysineBy similarity1
Modified residuei55N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysine; alternateBy similarity1
Modified residuei115N6-succinyllysine; alternateBy similarity1
Modified residuei146PhosphoserineCombined sources1
Modified residuei154N6-acetyllysine; alternateCombined sources1
Modified residuei154N6-succinyllysine; alternateBy similarity1
Modified residuei197N6-acetyllysineCombined sources1
Modified residuei270N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP36542.
MaxQBiP36542.
PaxDbiP36542.
PeptideAtlasiP36542.
PRIDEiP36542.
TopDownProteomicsiP36542-1. [P36542-1]
P36542-2. [P36542-2]

2D gel databases

UCD-2DPAGEP36542.

PTM databases

iPTMnetiP36542.
PhosphoSitePlusiP36542.
SwissPalmiP36542.

Expressioni

Tissue specificityi

Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta.

Gene expression databases

BgeeiENSG00000165629.
CleanExiHS_ATP5C1.
GenevisibleiP36542. HS.

Organism-specific databases

HPAiHPA060949.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi106997. 114 interactors.
IntActiP36542. 47 interactors.
MINTiMINT-1378900.
STRINGi9606.ENSP00000349142.

Structurei

3D structure databases

ProteinModelPortaliP36542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1531. Eukaryota.
COG0224. LUCA.
GeneTreeiENSGT00390000006837.
HOGENOMiHOG000215911.
HOVERGENiHBG000933.
InParanoidiP36542.
KOiK02136.
OMAiYQEFALV.
OrthoDBiEOG091G0XX7.
PhylomeDBiP36542.
TreeFamiTF105765.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
InterProiIPR000131. ATP_synth_F1_gsu.
IPR023632. ATP_synth_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Liver (identifier: P36542-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM
60 70 80 90 100
VAAAKYARAE RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR
110 120 130 140 150
GLCGAIHSSI AKQMKSEVAT LTAAGKEVML VGIGDKIRGI LYRTHSDQFL
160 170 180 190 200
VAFKEVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNKF RSVISYKTEE
210 220 230 240 250
KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY SLKESTTSEQ
260 270 280 290
SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
Length:298
Mass (Da):32,996
Last modified:June 1, 1994 - v1
Checksum:i021A95168FD53E04
GO
Isoform Heart (identifier: P36542-2) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     298-298: Missing.

Show »
Length:297
Mass (Da):32,881
Checksum:iCA95168FD53E0447
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45T → A in AAH16812 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000439298Missing in isoform Heart. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16561 Genomic DNA. Translation: BAA03994.1.
D16561 Genomic DNA. Translation: BAA03995.1.
D16562 mRNA. Translation: BAA03996.1.
D16563 mRNA. Translation: BAA03997.1.
AK292896 mRNA. Translation: BAF85585.1.
CR457403 mRNA. Translation: CAG33684.1.
AL353754, AL158044 Genomic DNA. Translation: CAH73453.1.
AL353754, AL158044 Genomic DNA. Translation: CAH73454.1.
AL158044, AL353754 Genomic DNA. Translation: CAI12960.1.
AL158044, AL353754 Genomic DNA. Translation: CAI12961.1.
CH471072 Genomic DNA. Translation: EAW86372.1.
CH471072 Genomic DNA. Translation: EAW86373.1.
BC000470 mRNA. Translation: AAH00470.1.
BC000931 mRNA. Translation: AAH00931.1.
BC013394 mRNA. Translation: AAH13394.1.
BC016812 mRNA. Translation: AAH16812.1.
BC020824 mRNA. Translation: AAH20824.1.
CCDSiCCDS31142.1. [P36542-1]
CCDS7081.1. [P36542-2]
PIRiA49108.
RefSeqiNP_001001973.1. NM_001001973.2. [P36542-1]
NP_005165.1. NM_005174.3. [P36542-2]
UniGeneiHs.271135.

Genome annotation databases

EnsembliENST00000335698; ENSP00000338568; ENSG00000165629. [P36542-2]
ENST00000356708; ENSP00000349142; ENSG00000165629. [P36542-1]
GeneIDi509.
KEGGihsa:509.
UCSCiuc001iju.4. human. [P36542-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16561 Genomic DNA. Translation: BAA03994.1.
D16561 Genomic DNA. Translation: BAA03995.1.
D16562 mRNA. Translation: BAA03996.1.
D16563 mRNA. Translation: BAA03997.1.
AK292896 mRNA. Translation: BAF85585.1.
CR457403 mRNA. Translation: CAG33684.1.
AL353754, AL158044 Genomic DNA. Translation: CAH73453.1.
AL353754, AL158044 Genomic DNA. Translation: CAH73454.1.
AL158044, AL353754 Genomic DNA. Translation: CAI12960.1.
AL158044, AL353754 Genomic DNA. Translation: CAI12961.1.
CH471072 Genomic DNA. Translation: EAW86372.1.
CH471072 Genomic DNA. Translation: EAW86373.1.
BC000470 mRNA. Translation: AAH00470.1.
BC000931 mRNA. Translation: AAH00931.1.
BC013394 mRNA. Translation: AAH13394.1.
BC016812 mRNA. Translation: AAH16812.1.
BC020824 mRNA. Translation: AAH20824.1.
CCDSiCCDS31142.1. [P36542-1]
CCDS7081.1. [P36542-2]
PIRiA49108.
RefSeqiNP_001001973.1. NM_001001973.2. [P36542-1]
NP_005165.1. NM_005174.3. [P36542-2]
UniGeneiHs.271135.

3D structure databases

ProteinModelPortaliP36542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106997. 114 interactors.
IntActiP36542. 47 interactors.
MINTiMINT-1378900.
STRINGi9606.ENSP00000349142.

PTM databases

iPTMnetiP36542.
PhosphoSitePlusiP36542.
SwissPalmiP36542.

Polymorphism and mutation databases

BioMutaiATP5C1.
DMDMi543875.

2D gel databases

UCD-2DPAGEP36542.

Proteomic databases

EPDiP36542.
MaxQBiP36542.
PaxDbiP36542.
PeptideAtlasiP36542.
PRIDEiP36542.
TopDownProteomicsiP36542-1. [P36542-1]
P36542-2. [P36542-2]

Protocols and materials databases

DNASUi509.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335698; ENSP00000338568; ENSG00000165629. [P36542-2]
ENST00000356708; ENSP00000349142; ENSG00000165629. [P36542-1]
GeneIDi509.
KEGGihsa:509.
UCSCiuc001iju.4. human. [P36542-1]

Organism-specific databases

CTDi509.
DisGeNETi509.
GeneCardsiATP5C1.
HGNCiHGNC:833. ATP5C1.
HPAiHPA060949.
MIMi108729. gene.
neXtProtiNX_P36542.
OpenTargetsiENSG00000165629.
PharmGKBiPA25125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1531. Eukaryota.
COG0224. LUCA.
GeneTreeiENSGT00390000006837.
HOGENOMiHOG000215911.
HOVERGENiHBG000933.
InParanoidiP36542.
KOiK02136.
OMAiYQEFALV.
OrthoDBiEOG091G0XX7.
PhylomeDBiP36542.
TreeFamiTF105765.

Enzyme and pathway databases

BioCyciZFISH:HS09257-MONOMER.
ReactomeiR-HSA-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

ChiTaRSiATP5C1. human.
GeneWikiiATP5C1.
GenomeRNAii509.
PROiP36542.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165629.
CleanExiHS_ATP5C1.
GenevisibleiP36542. HS.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
InterProiIPR000131. ATP_synth_F1_gsu.
IPR023632. ATP_synth_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPG_HUMAN
AccessioniPrimary (citable) accession number: P36542
Secondary accession number(s): A8KA31
, Q5VYP3, Q6I9V2, Q96AS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.