Reviewed, UniProtKB/Swiss-Prot P36537 (UDB10_HUMAN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B10
      Short name=UDPGT 2B10
    EC=2.4.1.17

Gene names

Name:

UGT2B10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid metabolic process Ref.1 Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 528	505	UDP-glucuronosyltransferase 2B10		PRO_0000036034
Regions
	Transmembrane	492 – 512	21	Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	314	1	N-linked (GlcNAc...) Ref.3
	Glycosylation	481	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P36537-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 5E6EA3DBC032C2E0	FASTA	528	60,774
	10 20 30 40 50 60 MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS 70 80 90 100 110 120 ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND 130 140 150 160 170 180 IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE 190 200 210 220 230 240 RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG 250 260 270 280 290 300 RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 310 320 330 340 350 360 NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND 370 380 390 400 410 420 LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS 430 440 450 460 470 480 STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 490 500 510 520 NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily." Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I. Biochem. Biophys. Res. Commun. 194:496-503(1993) [PubMed: 8333863] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, MASS SPECTROMETRY. Tissue: Plasma.
[4]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X63359 mRNA. Translation: CAA44961.1. BC113649 mRNA. Translation: AAI13650.1.
IPI	IPI00003836.
PIR	JN0620.
RefSeq	NP_001066.1.
UniGene	Hs.201634
3D structure databases
SMR	P36537. Positions 284-450.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	P36537.
Genome annotation databases
Ensembl	ENSG00000109181. Homo sapiens. [Contig view]
GeneID	7365.
KEGG	hsa:7365.
UCSC	uc003hee.1. human.
Organism-specific databases
GeneCards	GC04P069730.
HGNC	HGNC:12544. UGT2B10.
MIM	600070. gene.
PharmGKB	PA37186.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P36537.
HOVERGEN	P36537.
Enzyme and pathway databases
BRENDA	2.4.1.17. 247.
Reactome	REACT_13433. Biological oxidations.
Gene expression databases
ArrayExpress	P36537.
Bgee	P36537.
CleanEx	HS_UGT2B10.
GermOnline	ENSG00000109181. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28838.
SOURCE	Search...

Entry information

Entry name

UDB10_HUMAN

Accession

Primary (citable) accession number: P36537
Secondary accession number(s): Q14CR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	July 7, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)