Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-glucuronosyltransferase 2B10

Gene

UGT2B10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: GO_Central

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. flavonoid biosynthetic process Source: GO_Central
  3. flavonoid glucuronidation Source: GO_Central
  4. lipid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B10 (EC:2.4.1.17)
Short name:
UDPGT 2B10
Gene namesi
Name:UGT2B10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:12544. UGT2B10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei492 – 51221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 2B10PRO_0000036034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)2 Publications
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP36537.
PaxDbiP36537.
PRIDEiP36537.

PTM databases

PhosphoSiteiP36537.

Expressioni

Gene expression databases

BgeeiP36537.
CleanExiHS_UGT2B10.
GenevestigatoriP36537.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113212. 1 interaction.
IntActiP36537. 1 interaction.
STRINGi9606.ENSP00000265403.

Structurei

3D structure databases

ProteinModelPortaliP36537.
SMRiP36537. Positions 250-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36537.
KOiK00699.
OMAiENIIMQL.
OrthoDBiEOG7GBFWS.
PhylomeDBiP36537.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH
60 70 80 90 100
EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ
110 120 130 140 150
KDTFWLPFSQ EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD
160 170 180 190 200
AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL
210 220 230 240 250
SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR
260 270 280 290 300
KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE
310 320 330 340 350
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT
360 370 380 390 400
RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD
410 420 430 440 450
NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD
460 470 480 490 500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV
510 520
ATVLFIITKC CLFCFWKFAR KGKKGKRD
Length:528
Mass (Da):60,774
Last modified:June 1, 1994 - v1
Checksum:i5E6EA3DBC032C2E0
GO
Isoform 2 (identifier: P36537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-239: Missing.

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):50,688
Checksum:i449302F7572B0544
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 23984Missing in isoform 2. 1 PublicationVSP_054337Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63359 mRNA. Translation: CAA44961.1.
AK292738 mRNA. Translation: BAF85427.1.
AK298432 mRNA. Translation: BAG60653.1.
AC021146 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05577.1.
BC113649 mRNA. Translation: AAI13650.1.
CCDSiCCDS75135.1. [P36537-2]
CCDS75136.1. [P36537-1]
PIRiJN0620.
RefSeqiNP_001066.1. NM_001075.5. [P36537-1]
NP_001138239.1. NM_001144767.2. [P36537-2]
NP_001277020.1. NM_001290091.1.
UniGeneiHs.201634.

Genome annotation databases

EnsembliENST00000265403; ENSP00000265403; ENSG00000109181. [P36537-1]
ENST00000458688; ENSP00000413420; ENSG00000109181. [P36537-2]
ENST00000615213; ENSP00000478760; ENSG00000275190. [P36537-1]
GeneIDi7365.
KEGGihsa:7365.
UCSCiuc003hee.3. human. [P36537-1]

Polymorphism databases

DMDMi549155.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63359 mRNA. Translation: CAA44961.1.
AK292738 mRNA. Translation: BAF85427.1.
AK298432 mRNA. Translation: BAG60653.1.
AC021146 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05577.1.
BC113649 mRNA. Translation: AAI13650.1.
CCDSiCCDS75135.1. [P36537-2]
CCDS75136.1. [P36537-1]
PIRiJN0620.
RefSeqiNP_001066.1. NM_001075.5. [P36537-1]
NP_001138239.1. NM_001144767.2. [P36537-2]
NP_001277020.1. NM_001290091.1.
UniGeneiHs.201634.

3D structure databases

ProteinModelPortaliP36537.
SMRiP36537. Positions 250-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113212. 1 interaction.
IntActiP36537. 1 interaction.
STRINGi9606.ENSP00000265403.

Chemistry

ChEMBLiCHEMBL6160.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiP36537.

Polymorphism databases

DMDMi549155.

Proteomic databases

MaxQBiP36537.
PaxDbiP36537.
PRIDEiP36537.

Protocols and materials databases

DNASUi7365.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265403; ENSP00000265403; ENSG00000109181. [P36537-1]
ENST00000458688; ENSP00000413420; ENSG00000109181. [P36537-2]
ENST00000615213; ENSP00000478760; ENSG00000275190. [P36537-1]
GeneIDi7365.
KEGGihsa:7365.
UCSCiuc003hee.3. human. [P36537-1]

Organism-specific databases

CTDi7365.
GeneCardsiGC04P069730.
HGNCiHGNC:12544. UGT2B10.
HPAiHPA045108.
MIMi600070. gene.
neXtProtiNX_P36537.
PharmGKBiPA37186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36537.
KOiK00699.
OMAiENIIMQL.
OrthoDBiEOG7GBFWS.
PhylomeDBiP36537.
TreeFamiTF315472.

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Miscellaneous databases

ChiTaRSiUGT2B10. human.
GeneWikiiUGT2B10.
GenomeRNAii7365.
NextBioi28838.
PROiP36537.
SOURCEiSearch...

Gene expression databases

BgeeiP36537.
CleanExiHS_UGT2B10.
GenevestigatoriP36537.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."
    Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I.
    Biochem. Biophys. Res. Commun. 194:496-503(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314.
    Tissue: Liver.

Entry informationi

Entry nameiUDB10_HUMAN
AccessioniPrimary (citable) accession number: P36537
Secondary accession number(s): A8K9M3, B4DPP1, Q14CR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 4, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.