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P36537

- UDB10_HUMAN

UniProt

P36537 - UDB10_HUMAN

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Protein

UDP-glucuronosyltransferase 2B10

Gene
UGT2B10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B10 (EC:2.4.1.17)
Short name:
UDPGT 2B10
Gene namesi
Name:UGT2B10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12544. UGT2B10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei492 – 51221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarityAdd
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 2B10PRO_0000036034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...)2 Publications
Glycosylationi481 – 4811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP36537.
PaxDbiP36537.
PRIDEiP36537.

PTM databases

PhosphoSiteiP36537.

Expressioni

Gene expression databases

BgeeiP36537.
CleanExiHS_UGT2B10.
GenevestigatoriP36537.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113212. 1 interaction.
IntActiP36537. 1 interaction.
STRINGi9606.ENSP00000265403.

Structurei

3D structure databases

ProteinModelPortaliP36537.
SMRiP36537. Positions 250-445.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP36537.
KOiK00699.
OMAiENIIMQL.
OrthoDBiEOG7GBFWS.
PhylomeDBiP36537.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P36537-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH    50
EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ 100
KDTFWLPFSQ EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD 150
AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL 200
SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR 250
KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 300
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT 350
RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD 400
NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD 450
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV 500
ATVLFIITKC CLFCFWKFAR KGKKGKRD 528
Length:528
Mass (Da):60,774
Last modified:June 1, 1994 - v1
Checksum:i5E6EA3DBC032C2E0
GO
Isoform 2 (identifier: P36537-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-239: Missing.

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):50,688
Checksum:i449302F7572B0544
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 23984Missing in isoform 2. VSP_054337Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63359 mRNA. Translation: CAA44961.1.
AK292738 mRNA. Translation: BAF85427.1.
AK298432 mRNA. Translation: BAG60653.1.
AC021146 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05577.1.
BC113649 mRNA. Translation: AAI13650.1.
PIRiJN0620.
RefSeqiNP_001066.1. NM_001075.5. [P36537-1]
NP_001138239.1. NM_001144767.2. [P36537-2]
NP_001277020.1. NM_001290091.1.
UniGeneiHs.201634.

Genome annotation databases

EnsembliENST00000265403; ENSP00000265403; ENSG00000109181.
ENST00000458688; ENSP00000413420; ENSG00000109181.
GeneIDi7365.
KEGGihsa:7365.
UCSCiuc003hee.3. human. [P36537-1]

Polymorphism databases

DMDMi549155.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63359 mRNA. Translation: CAA44961.1 .
AK292738 mRNA. Translation: BAF85427.1 .
AK298432 mRNA. Translation: BAG60653.1 .
AC021146 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05577.1 .
BC113649 mRNA. Translation: AAI13650.1 .
PIRi JN0620.
RefSeqi NP_001066.1. NM_001075.5. [P36537-1 ]
NP_001138239.1. NM_001144767.2. [P36537-2 ]
NP_001277020.1. NM_001290091.1.
UniGenei Hs.201634.

3D structure databases

ProteinModelPortali P36537.
SMRi P36537. Positions 250-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113212. 1 interaction.
IntActi P36537. 1 interaction.
STRINGi 9606.ENSP00000265403.

Chemistry

ChEMBLi CHEMBL6160.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P36537.

Polymorphism databases

DMDMi 549155.

Proteomic databases

MaxQBi P36537.
PaxDbi P36537.
PRIDEi P36537.

Protocols and materials databases

DNASUi 7365.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265403 ; ENSP00000265403 ; ENSG00000109181 .
ENST00000458688 ; ENSP00000413420 ; ENSG00000109181 .
GeneIDi 7365.
KEGGi hsa:7365.
UCSCi uc003hee.3. human. [P36537-1 ]

Organism-specific databases

CTDi 7365.
GeneCardsi GC04P069730.
HGNCi HGNC:12544. UGT2B10.
HPAi HPA045108.
MIMi 600070. gene.
neXtProti NX_P36537.
PharmGKBi PA37186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P36537.
KOi K00699.
OMAi ENIIMQL.
OrthoDBi EOG7GBFWS.
PhylomeDBi P36537.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 2681.
Reactomei REACT_6784. Glucuronidation.

Miscellaneous databases

ChiTaRSi UGT2B10. human.
GeneWikii UGT2B10.
GenomeRNAii 7365.
NextBioi 28838.
PROi P36537.
SOURCEi Search...

Gene expression databases

Bgeei P36537.
CleanExi HS_UGT2B10.
Genevestigatori P36537.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."
    Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I.
    Biochem. Biophys. Res. Commun. 194:496-503(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314.
    Tissue: Liver.

Entry informationi

Entry nameiUDB10_HUMAN
AccessioniPrimary (citable) accession number: P36537
Secondary accession number(s): A8K9M3, B4DPP1, Q14CR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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