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Protein

54S ribosomal protein L40, mitochondrial

Gene

MRPL40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L40, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL24m1 Publication
YmL40
Gene namesi
Name:MRPL40
Ordered Locus Names:YPL173W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL173W.
SGDiS000006094. MRPL40.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000305822 – 29754S ribosomal protein L40, mitochondrialAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP36534.
PRIDEiP36534.
TopDownProteomicsiP36534.

PTM databases

iPTMnetiP36534.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uL24m forms the wall of the exit tunnel.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MRP20P323874EBI-15595,EBI-15599

Protein-protein interaction databases

BioGridi36010. 94 interactors.
DIPiDIP-7947N.
IntActiP36534. 10 interactors.
MINTiMINT-2787372.
STRINGi4932.YPL173W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20Q1-297[»]
5MRCelectron microscopy3.25Q2-297[»]
5MREelectron microscopy3.75Q2-297[»]
5MRFelectron microscopy4.97Q2-297[»]
ProteinModelPortaliP36534.
SMRiP36534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 96KOWAdd BLAST34

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000000986.
InParanoidiP36534.
KOiK02895.
OMAiRNPYSKH.
OrthoDBiEOG092C4ZZU.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like_sf.
PANTHERiPTHR12903. PTHR12903. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiView protein in PROSITE
PS01108. RIBOSOMAL_L24. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSYQHLSN VGSRVMKRLG NRPKNFLPHS EKFIKKSTPE FMKSDLKEVD
60 70 80 90 100
EKTSFKSEKE WKFIPGDRVV VMSGASKGNI AVIKSFDKRT NSFILDENGP
110 120 130 140 150
TKTVPVPKQF WLEGQTSHMI TIPVSILGKD LRLVADIDDE KTPGKTRTVA
160 170 180 190 200
VRDVSFNGSY YDADYKKVMP YRCVKGQPDL IIPWPKPDPI DVQTNLATDP
210 220 230 240 250
VIAREQTFWV DSVVRNPIPK KAIPSIRNPH SKYKRGTLTA KDIAKLVAPE
260 270 280 290
MPLTEVRKSH LAEKKELAER EVPKLTEEDM EAIGARVFEF LEKQKRE
Length:297
Mass (Da):33,751
Last modified:October 1, 1996 - v2
Checksum:iD5BB2B7AE13ECBF9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179D → G in AAT92872 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73529 Genomic DNA. Translation: CAA97880.1.
AY692853 Genomic DNA. Translation: AAT92872.1.
BK006949 Genomic DNA. Translation: DAA11261.1.
PIRiS65185.
RefSeqiNP_015152.1. NM_001183987.1.

Genome annotation databases

EnsemblFungiiYPL173W; YPL173W; YPL173W.
GeneIDi855930.
KEGGisce:YPL173W.

Similar proteinsi

Entry informationi

Entry nameiRM40_YEAST
AccessioniPrimary (citable) accession number: P36534
Secondary accession number(s): D6W3J5, Q6B277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names