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P36531

- RM36_YEAST

UniProt

P36531 - RM36_YEAST

Protein

54S ribosomal protein L36, mitochondrial

Gene

MRPL36

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.2 Publications

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. mitochondrial translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29079-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    54S ribosomal protein L36, mitochondrial
    Alternative name(s):
    YmL36
    Gene namesi
    Name:MRPL36
    Ordered Locus Names:YBR122C
    ORF Names:YBR0918
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR122c.
    SGDiS000000326. MRPL36.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1414Mitochondrion1 PublicationAdd
    BLAST
    Chaini15 – 17716354S ribosomal protein L36, mitochondrialPRO_0000030580Add
    BLAST

    Proteomic databases

    MaxQBiP36531.
    PaxDbiP36531.
    PeptideAtlasiP36531.

    Expressioni

    Gene expression databases

    GenevestigatoriP36531.

    Interactioni

    Subunit structurei

    Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSB3P436031EBI-15582,EBI-22980
    YSC84P327931EBI-15582,EBI-24460

    Protein-protein interaction databases

    BioGridi32824. 46 interactions.
    DIPiDIP-4628N.
    IntActiP36531. 13 interactions.
    MINTiMINT-566842.
    STRINGi4932.YBR122C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW4electron microscopy3.20V1-177[»]
    ProteinModelPortaliP36531.
    SMRiP36531. Positions 38-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni36 – 11883Sufficient for general mitochondrial translationAdd
    BLAST
    Regioni87 – 17791Sufficient for dosage suppression of COX2 mutationAdd
    BLAST

    Domaini

    Contains two functional domains. The central domain is sufficient for general mitochondrial translation but not suppression of COX2 mutants. The C-terminus sequence is sufficient for dosage suppression of COX2 mutants.1 Publication

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG42857.
    HOGENOMiHOG000248746.
    OMAiPLWNPSR.
    OrthoDBiEOG7WT4D3.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36531-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKSIFAKRF ASTGSYPGST RITLPRRPAK KIQLGKSRPA IYHQFNVKME    50
    LSDGSVVIRR SQYPKGEIRL IQDQRNNPLW NPSRDDLVVV DANSGGSLDR 100
    FNKRYSSLFS VDSTTPNSSS ETVELSEENK KKTQIKKEEK EDVSEKAFGM 150
    DDYLSLLDDS EQQIKSGKLA SKKRDKK 177
    Length:177
    Mass (Da):20,091
    Last modified:December 20, 2005 - v3
    Checksum:i7A8DF86EE899B848
    GO

    Sequence cautioni

    The sequence CAA55624.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA85079.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78993 Genomic DNA. Translation: CAA55624.1. Different initiation.
    Z35991 Genomic DNA. Translation: CAA85079.1. Different initiation.
    BK006936 Genomic DNA. Translation: DAA07240.1.
    PIRiS44701.
    RefSeqiNP_009680.2. NM_001178470.1.

    Genome annotation databases

    EnsemblFungiiYBR122C; YBR122C; YBR122C.
    GeneIDi852419.
    KEGGisce:YBR122C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78993 Genomic DNA. Translation: CAA55624.1 . Different initiation.
    Z35991 Genomic DNA. Translation: CAA85079.1 . Different initiation.
    BK006936 Genomic DNA. Translation: DAA07240.1 .
    PIRi S44701.
    RefSeqi NP_009680.2. NM_001178470.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW4 electron microscopy 3.20 V 1-177 [» ]
    ProteinModelPortali P36531.
    SMRi P36531. Positions 38-108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32824. 46 interactions.
    DIPi DIP-4628N.
    IntActi P36531. 13 interactions.
    MINTi MINT-566842.
    STRINGi 4932.YBR122C.

    Proteomic databases

    MaxQBi P36531.
    PaxDbi P36531.
    PeptideAtlasi P36531.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR122C ; YBR122C ; YBR122C .
    GeneIDi 852419.
    KEGGi sce:YBR122C.

    Organism-specific databases

    CYGDi YBR122c.
    SGDi S000000326. MRPL36.

    Phylogenomic databases

    eggNOGi NOG42857.
    HOGENOMi HOG000248746.
    OMAi PLWNPSR.
    OrthoDBi EOG7WT4D3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29079-MONOMER.

    Miscellaneous databases

    NextBioi 971282.

    Gene expression databases

    Genevestigatori P36531.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
      Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
      Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria."
      Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M.
      FEBS Lett. 284:51-56(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 15-51, SUBUNIT.
      Strain: 07173.
    5. "Mitochondrial translation of Saccharomyces cerevisiae COX2 mRNA is controlled by the nucleotide sequence specifying the pre-Cox2p leader peptide."
      Bonnefoy N., Bsat N., Fox T.D.
      Mol. Cell. Biol. 21:2359-2372(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components."
      Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K.
      Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    10. "MrpL36p, a highly diverged L31 ribosomal protein homolog with additional functional domains in Saccharomyces cerevisiae mitochondria."
      Williams E.H., Perez-Martinez X., Fox T.D.
      Genetics 167:65-75(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN.

    Entry informationi

    Entry nameiRM36_YEAST
    AccessioniPrimary (citable) accession number: P36531
    Secondary accession number(s): D6VQC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3