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Protein

54S ribosomal protein L17, mitochondrial

Gene

MRPL17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 7400 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33249-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L17, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL461 Publication
YmL17/YmL30
Gene namesi
Name:MRPL17
Synonyms:MRPL30
Ordered Locus Names:YNL252C
ORF Names:N0864
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL252C.
SGDiS000005196. MRPL17.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19Mitochondrion1 PublicationAdd BLAST19
ChainiPRO_000003057820 – 28154S ribosomal protein L17, mitochondrialAdd BLAST262

Proteomic databases

MaxQBiP36528.
PRIDEiP36528.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.4 Publications

Protein-protein interaction databases

BioGridi35587. 501 interactors.
DIPiDIP-4278N.
IntActiP36528. 8 interactors.
MINTiMINT-487311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.2061-281[»]
5MRCelectron microscopy3.2561-281[»]
5MREelectron microscopy3.7561-281[»]
5MRFelectron microscopy4.9761-281[»]
ProteinModelPortaliP36528.
SMRiP36528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000248758.
InParanoidiP36528.
KOiK17427.
OMAiLPFTRYF.
OrthoDBiEOG092C3HPX.

Family and domain databases

InterProiView protein in InterPro
IPR021757. Ribosomal_L46.
PfamiView protein in Pfam
PF11788. MRP-L46. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNLMLKRG LATATATASS APPKIKVGVL LSRIPIIKSE LNELEKKYYE
60 70 80 90 100
YQSELEKRLM WTFPAYFYFK KGTVAEHKFL SLQKGPISKK NGIWFPRGIP
110 120 130 140 150
DIKHGRERST KQEVKLSDDS TVAFSNNQKE QSKDDVNRPV IPNDRITEAD
160 170 180 190 200
RSNDMKSLER QLSRTLYLLV KDKSGTWKFP NFDLSDESKP LHVHAENELK
210 220 230 240 250
LLSGDQIYTW SVSATPIGVL QDERNRTAEF IVKSHILAGK FDLVASKNDA
260 270 280
FEDFAWLTKG EISEYVPKDY FNKTEFLLAD N
Length:281
Mass (Da):32,213
Last modified:October 1, 1996 - v2
Checksum:iBD4F2B6D7C2F44DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65492.1.
Z71528 Genomic DNA. Translation: CAA96159.1.
AY558015 Genomic DNA. Translation: AAS56341.1.
BK006947 Genomic DNA. Translation: DAA10307.1.
PIRiS63225.
RefSeqiNP_014147.1. NM_001183090.1.

Genome annotation databases

EnsemblFungiiYNL252C; YNL252C; YNL252C.
GeneIDi855469.
KEGGisce:YNL252C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65492.1.
Z71528 Genomic DNA. Translation: CAA96159.1.
AY558015 Genomic DNA. Translation: AAS56341.1.
BK006947 Genomic DNA. Translation: DAA10307.1.
PIRiS63225.
RefSeqiNP_014147.1. NM_001183090.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.2061-281[»]
5MRCelectron microscopy3.2561-281[»]
5MREelectron microscopy3.7561-281[»]
5MRFelectron microscopy4.9761-281[»]
ProteinModelPortaliP36528.
SMRiP36528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35587. 501 interactors.
DIPiDIP-4278N.
IntActiP36528. 8 interactors.
MINTiMINT-487311.

Proteomic databases

MaxQBiP36528.
PRIDEiP36528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL252C; YNL252C; YNL252C.
GeneIDi855469.
KEGGisce:YNL252C.

Organism-specific databases

EuPathDBiFungiDB:YNL252C.
SGDiS000005196. MRPL17.

Phylogenomic databases

HOGENOMiHOG000248758.
InParanoidiP36528.
KOiK17427.
OMAiLPFTRYF.
OrthoDBiEOG092C3HPX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33249-MONOMER.

Miscellaneous databases

PROiPR:P36528.

Family and domain databases

InterProiView protein in InterPro
IPR021757. Ribosomal_L46.
PfamiView protein in Pfam
PF11788. MRP-L46. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM17_YEAST
AccessioniPrimary (citable) accession number: P36528
Secondary accession number(s): D6W0U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.