P36525 (RM24_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
54S ribosomal protein L24, mitochondrial

Alternative name(s):
YmL14/YmL24

Gene names

Name:	MRPL24
Synonyms:	MRPL14
Ordered Locus Names:	YMR193W
ORF Names:	YM9646.05

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4 Ref.5
Subcellular location	Mitochondrion Ref.7.
Miscellaneous	Present with 4000 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the ribosomal protein L28P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial translation Inferred by curator Ref.5. Source: SGD
Cellular component	mitochondrial large ribosomal subunit Inferred from direct assay Ref.5. Source: SGD
Molecular function	structural constituent of ribosome Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SUA7	P29055	1	EBI-15545,EBI-19123

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 21	21	Mitochondrion Ref.4
	Chain	22 – 258	237	54S ribosomal protein L24, mitochondrial		PRO_0000030509
Experimental info
	Sequence conflict	72	1	G → K AA sequence Ref.5
	Sequence conflict	76	1	G → D AA sequence Ref.5
	Sequence conflict	130	1	G → Q AA sequence Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P36525 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: F49DC1D41860E359	FASTA	258	30,049
	10 20 30 40 50 60 MQKIFRPFQL TRGFTSSVKN FRQWRLIETR KIAKQPNYQV GDAKPLHMPK ERKKFPDYKY 70 80 90 100 110 120 GESNIFKQSN KGLYGGSFVQ FGNNISESKA KTRKKWLPNV VKKGLWSETL NRKISIKMTA 130 140 150 160 170 180 KVLKTISKEG GIDNYLTKEK SARIKELGPT GWKLRYRVLK RKDEIENPPH KDAPIIEMAG 190 200 210 220 230 240 GKKAKIYYDE IVNGSPRKIS VGRRRLMSFL YPLEKLEYRS VGKDLNYKKF VELFADVPVK 250 DILARLEDHK FDLSTITV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria." Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M. FEBS Lett. 284:51-56(1991) [PubMed: 2060626] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-49 AND 72-87, SUBUNIT. Strain: 07173.
[5]	"Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae." Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K. Eur. J. Biochem. 245:449-456(1997) [PubMed: 9151978] [Abstract] Cited for: PROTEIN SEQUENCE OF 72-83 AND 129-138, SUBUNIT. Strain: 07173.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z47815 Genomic DNA. Translation: CAA87814.1. AY557982 Genomic DNA. Translation: AAS56308.1. BK006946 Genomic DNA. Translation: DAA10091.1.
PIR	S50921.
RefSeq	NP_013918.1. NM_001182700.1.
3D structure databases
ProteinModelPortal	P36525.
SMR	P36525. Positions 69-138.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3847N.
IntAct	P36525. 6 interactions.
MINT	MINT-550659.
STRING	P36525.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR193W; YMR193W; YMR193W.
GeneID	855231.
KEGG	sce:YMR193W.
NMPDR	fig|4932.3.peg.4970.
Organism-specific databases
CYGD	YMR193w.
SGD	S000004806. MRPL24.
Phylogenomic databases
eggNOG	fuNOG05163.
GeneTree	EFGT00050000006603.
HOGENOM	HBG396219.
OMA	IKMTAKV.
OrthoDB	EOG4F21CZ.
Gene expression databases
ArrayExpress	P36525.
Genevestigator	P36525.
GermOnline	YMR193W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001383. Ribosomal_L28. [Graphical view]
Pfam	PF00830. Ribosomal_L28. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978771.

Entry information

Entry name

RM24_YEAST

Accession

Primary (citable) accession number: P36525
Secondary accession number(s): D6W017

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program