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P36520

- RM10_YEAST

UniProt

P36520 - RM10_YEAST

Protein

54S ribosomal protein L10, mitochondrial

Gene

MRPL10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. mitochondrial translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33275-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    54S ribosomal protein L10, mitochondrial
    Alternative name(s):
    YmL10/YmL18
    Gene namesi
    Name:MRPL10
    Synonyms:MRPL18
    Ordered Locus Names:YNL284C
    ORF Names:N0580
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL284c.
    SGDiS000005228. MRPL10.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5757Mitochondrion1 PublicationAdd
    BLAST
    Chaini58 – 32226554S ribosomal protein L10, mitochondrialPRO_0000030468Add
    BLAST

    Proteomic databases

    MaxQBiP36520.
    PaxDbiP36520.

    Expressioni

    Gene expression databases

    GenevestigatoriP36520.

    Interactioni

    Subunit structurei

    Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

    Protein-protein interaction databases

    BioGridi35556. 48 interactions.
    DIPiDIP-6771N.
    IntActiP36520. 37 interactions.
    MINTiMINT-613283.
    STRINGi4932.YNL284C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW4electron microscopy3.20J1-322[»]
    ProteinModelPortaliP36520.
    SMRiP36520. Positions 64-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L15P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0200.
    GeneTreeiENSGT00390000009040.
    HOGENOMiHOG000231264.
    KOiK02876.
    OMAiPHWFLEK.
    OrthoDBiEOG7C2RBK.

    Family and domain databases

    HAMAPiMF_01341. Ribosomal_L15.
    InterProiIPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view]
    PANTHERiPTHR12934. PTHR12934. 1 hit.
    PfamiPF00828. Ribosomal_L18e. 1 hit.
    [Graphical view]
    SUPFAMiSSF52080. SSF52080. 1 hit.
    TIGRFAMsiTIGR01071. rplO_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAERQTGLR NSFTTVIGRK LINTFVPSMM LTSVAGNDIF FRGLFKSPVL    50
    AFQSYRYVSI LGQLKPSDGS TKSFKRLGRG PSSGLGKTSG RGQKGQKARG 100
    KVKSWFEGGQ TPIYKLFPKI GFTNVGAKPL KELNLKRIQW FHDKNRLHLQ 150
    PGEVLDMNKM RKLGLVTGPI KYGVKILASG KFHYNLPIAL EASRASAKAI 200
    AAIEKAGGKF TARYYTPLGL RAHLNPQWFL EKRGRVPLQA RPTKRRDIDF 250
    YSKEEKRGYL VMEKDKLLQD IKEAQNKGSR HFLKQNVKKS SLEIELEELS 300
    PEKDWVPVVS NSKVMNIKAL DH 322
    Length:322
    Mass (Da):36,347
    Last modified:October 1, 1996 - v2
    Checksum:iFD56AB98F62B4A07
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681D → K AA sequence (PubMed:2060626)Curated
    Sequence conflicti71 – 711T → G AA sequence (PubMed:2060626)Curated
    Sequence conflicti182 – 1821F → I AA sequence (PubMed:9151978)Curated
    Sequence conflicti188 – 1881I → K AA sequence (PubMed:9151978)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71560 Genomic DNA. Translation: CAA96198.1.
    BK006947 Genomic DNA. Translation: DAA10276.1.
    PIRiS63258.
    RefSeqiNP_014115.1. NM_001183122.1.

    Genome annotation databases

    EnsemblFungiiYNL284C; YNL284C; YNL284C.
    GeneIDi855436.
    KEGGisce:YNL284C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71560 Genomic DNA. Translation: CAA96198.1 .
    BK006947 Genomic DNA. Translation: DAA10276.1 .
    PIRi S63258.
    RefSeqi NP_014115.1. NM_001183122.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW4 electron microscopy 3.20 J 1-322 [» ]
    ProteinModelPortali P36520.
    SMRi P36520. Positions 64-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35556. 48 interactions.
    DIPi DIP-6771N.
    IntActi P36520. 37 interactions.
    MINTi MINT-613283.
    STRINGi 4932.YNL284C.

    Proteomic databases

    MaxQBi P36520.
    PaxDbi P36520.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL284C ; YNL284C ; YNL284C .
    GeneIDi 855436.
    KEGGi sce:YNL284C.

    Organism-specific databases

    CYGDi YNL284c.
    SGDi S000005228. MRPL10.

    Phylogenomic databases

    eggNOGi COG0200.
    GeneTreei ENSGT00390000009040.
    HOGENOMi HOG000231264.
    KOi K02876.
    OMAi PHWFLEK.
    OrthoDBi EOG7C2RBK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33275-MONOMER.

    Miscellaneous databases

    NextBioi 979320.
    PROi P36520.

    Gene expression databases

    Genevestigatori P36520.

    Family and domain databases

    HAMAPi MF_01341. Ribosomal_L15.
    InterProi IPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view ]
    PANTHERi PTHR12934. PTHR12934. 1 hit.
    Pfami PF00828. Ribosomal_L18e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52080. SSF52080. 1 hit.
    TIGRFAMsi TIGR01071. rplO_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria."
      Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M.
      FEBS Lett. 284:51-56(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 58-71, SUBUNIT.
      Strain: 07173.
    4. "Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae."
      Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K.
      Eur. J. Biochem. 245:449-456(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 182-195 AND 247-253, SUBUNIT.
      Strain: 07173.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.

    Entry informationi

    Entry nameiRM10_YEAST
    AccessioniPrimary (citable) accession number: P36520
    Secondary accession number(s): D6W0R0, P36524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5350 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3