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P36520 (RM10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
54S ribosomal protein L10, mitochondrial
Alternative name(s):
YmL10/YmL18
Gene names
Name:MRPL10
Synonyms:MRPL18
Ordered Locus Names:YNL284C
ORF Names:N0580
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.3 Ref.4

Subcellular location

Mitochondrion Ref.5 Ref.7.

Miscellaneous

Present with 5350 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ribosomal protein L15P family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processmitochondrial translation

Inferred by curator Ref.4. Source: SGD

   Cellular_componentmitochondrial large ribosomal subunit

Inferred from direct assay Ref.4. Source: SGD

   Molecular_functionstructural constituent of ribosome

Inferred from direct assay Ref.4. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5757Mitochondrion Ref.3
Chain58 – 32226554S ribosomal protein L10, mitochondrial HAMAP-Rule MF_01341_B
PRO_0000030468

Experimental info

Sequence conflict681D → K AA sequence Ref.3
Sequence conflict711T → G AA sequence Ref.3
Sequence conflict1821F → I AA sequence Ref.4
Sequence conflict1881I → K AA sequence Ref.4

Sequences

Sequence LengthMass (Da)Tools
P36520 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: FD56AB98F62B4A07

FASTA32236,347
        10         20         30         40         50         60 
MKAERQTGLR NSFTTVIGRK LINTFVPSMM LTSVAGNDIF FRGLFKSPVL AFQSYRYVSI 

        70         80         90        100        110        120 
LGQLKPSDGS TKSFKRLGRG PSSGLGKTSG RGQKGQKARG KVKSWFEGGQ TPIYKLFPKI 

       130        140        150        160        170        180 
GFTNVGAKPL KELNLKRIQW FHDKNRLHLQ PGEVLDMNKM RKLGLVTGPI KYGVKILASG 

       190        200        210        220        230        240 
KFHYNLPIAL EASRASAKAI AAIEKAGGKF TARYYTPLGL RAHLNPQWFL EKRGRVPLQA 

       250        260        270        280        290        300 
RPTKRRDIDF YSKEEKRGYL VMEKDKLLQD IKEAQNKGSR HFLKQNVKKS SLEIELEELS 

       310        320 
PEKDWVPVVS NSKVMNIKAL DH 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria."
Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M.
FEBS Lett. 284:51-56(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 58-71, SUBUNIT.
Strain: 07173.
[4]"Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae."
Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K.
Eur. J. Biochem. 245:449-456(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 182-195 AND 247-253, SUBUNIT.
Strain: 07173.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: ATCC 76625 / YPH499.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71560 Genomic DNA. Translation: CAA96198.1.
BK006947 Genomic DNA. Translation: DAA10276.1.
PIRS63258.
RefSeqNP_014115.1. NM_001183122.1.

3D structure databases

ProteinModelPortalP36520.
SMRP36520. Positions 64-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35556. 48 interactions.
DIPDIP-6771N.
IntActP36520. 37 interactions.
MINTMINT-613283.
STRING4932.YNL284C.

Proteomic databases

PaxDbP36520.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL284C; YNL284C; YNL284C.
GeneID855436.
KEGGsce:YNL284C.

Organism-specific databases

CYGDYNL284c.
SGDS000005228. MRPL10.

Phylogenomic databases

eggNOGCOG0200.
GeneTreeENSGT00390000009040.
HOGENOMHOG000231264.
KOK02876.
OMAPHWFLEK.
OrthoDBEOG7C2RBK.

Enzyme and pathway databases

BioCycYEAST:G3O-33275-MONOMER.

Gene expression databases

GenevestigatorP36520.

Family and domain databases

HAMAPMF_01341_B. Ribosomal_L15_B.
InterProIPR005749. Ribosomal_L15_bac-type.
IPR021131. Ribosomal_L18e/L15P.
[Graphical view]
PANTHERPTHR12934. PTHR12934. 1 hit.
PfamPF00828. Ribosomal_L18e. 1 hit.
[Graphical view]
SUPFAMSSF52080. SSF52080. 1 hit.
TIGRFAMsTIGR01071. rplO_bact. 1 hit.
ProtoNetSearch...

Other

NextBio979320.
PROP36520.

Entry information

Entry nameRM10_YEAST
AccessionPrimary (citable) accession number: P36520
Secondary accession number(s): D6W0R0, P36524
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries