P36519 (RM07_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
54S ribosomal protein L7, mitochondrial

Alternative name(s):
YmL5
YmL7

Gene names

Name:	MRPL7
Ordered Locus Names:	YDR237W
ORF Names:	YD8419.04

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4
Subcellular location	Mitochondrion Ref.5.
Sequence similarities	Belongs to the ribosomal protein L5P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial translation Inferred by curator. Source: SGD
Cellular component	mitochondrial large ribosomal subunit Inferred from direct assay. Source: SGD
Molecular function	structural constituent of ribosome Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 19	19	Mitochondrion Ref.4
	Chain	20 – 292	273	54S ribosomal protein L7, mitochondrial		PRO_0000030545
Experimental info
	Sequence conflict	23	1	C → N AA sequence Ref.4
	Sequence conflict	33	1	V → W AA sequence Ref.4
	Sequence conflict	85	1	N → K in AAS56071. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P36519 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 8724840D4C92B8B8	FASTA	292	33,099
	10 20 30 40 50 60 MQRFSLVTHR SFSHSCVKPK SACSLVKPVH HLVKIDKSKL SPRFPELKYD KSDIRSPGFK 70 80 90 100 110 120 PKDTHADRLN DHYLNTLQSD LLLINYSHNA AVVKGLKQRA WSGDSPYHLN RPPKNPRGSK 130 140 150 160 170 180 AQLPDIHPIK WSNIPGLESV VINCFVREAR ENQLLAITAA LQLQQITGCK PHPIFSKNDV 190 200 210 220 230 240 PTWKLRKGHQ MGAKVELKGK EMSQFLSTLT EIVLPRIREY KGISNQSGNR FGGISFGLTA 250 260 270 280 290 EDIKFFPEID ANQDSWPKTF GMHININTSA QLDYQARTLL SGFQFPFFGE EK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria." Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M. FEBS Lett. 284:51-56(1991) [PubMed: 2060626] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-44, SUBUNIT. Strain: 07173.
[5]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49701 Genomic DNA. Translation: CAA89723.1. AY557745 Genomic DNA. Translation: AAS56071.1. BK006938 Genomic DNA. Translation: DAA12078.1.
PIR	S54533.
RefSeq	NP_010523.1. NM_001180545.1.
3D structure databases
ProteinModelPortal	P36519.
SMR	P36519. Positions 66-289.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6804N.
IntAct	P36519. 9 interactions.
MINT	MINT-613214.
STRING	P36519.
Proteomic databases
PeptideAtlas	P36519.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR237W; YDR237W; YDR237W.
GeneID	851823.
KEGG	sce:YDR237W.
NMPDR	fig|4932.3.peg.1280.
Organism-specific databases
CYGD	YDR237w.
SGD	S000002645. MRPL7.
Phylogenomic databases
eggNOG	fuNOG05166.
HOGENOM	HBG396540.
OMA	PVHHLVK.
OrthoDB	EOG4ZW8M3.
Gene expression databases
ArrayExpress	P36519.
Genevestigator	P36519.
GermOnline	YDR237W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002132. Ribosomal_L5. IPR022803. Ribosomal_L5_domain. [Graphical view]
Gene3D	G3DSA:3.30.1440.10. Ribosomal_L5. 2 hits.
PANTHER	PTHR11994. Ribosomal_L5. 1 hit.
Pfam	PF00281. Ribosomal_L5. 1 hit. PF00673. Ribosomal_L5_C. 1 hit. [Graphical view]
SUPFAM	SSF55282. Ribosomal_L5. 1 hit.
PROSITE	PS00358. RIBOSOMAL_L5. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	969698.

Entry information

Entry name

RM07_YEAST

Accession

Primary (citable) accession number: P36519
Secondary accession number(s): D6VSL8, E9P8T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program